СOVID-19 as a probable trigger factor for autoimmune diseases in children


DOI: https://dx.doi.org/10.18565/epidem.2022.12.1.93-100

Karpovich G.S., Kuimova I.V., Serova Yu.S.

1) Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia; 2) Children’s City Hospital Three, Novosibirsk, Russia
The emergence of SARS-CoV-2 led to the largest pandemic in modern history with a huge number of severe infection cases and deaths. With general bad statistics, the COVID-19 situation looked relatively safe in pediatric practice. It was characterized by a large proportion of patients with asymptomatic and mild infections, by significantly lower rates of morbidity and even more mortality. But this «imaginary» well-being was soon replaced by a disturbing trend. In clinical practice, children came under recording to have forms of delayed multiple organ inflammatory damage, the so-called multisystem inflammatory syndrome in children (MIS-C). In addition to MIS-C, the role of COVID-19 as a kind of trigger in the development of various autoimmune diseases is not ruled out. Long-term follow-up of pediatric patients who have experienced COVID-19 is currently virtually absent due to objective reasons. The paper describes clinical cases of the development of autoimmune diseases in children after suffering from COVID-19. It discusses the role of infection caused by SARS-CoV-2 as a trigger for the development of autoimmune diseases.
Keywords: PANDAS, SARS-CoV-2, COVID-19, autoimmune diseases, pediatrics, infectious diseases, ulcerative colitis, autoimmune hepatitis
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About the Autors

Gleb S. Karpovich, Assistant Lecturer, Department of Infectious Diseases, Novosibirsk State Medical University; Infectiologist, Children’s City Hospital Three, Novosibirsk, Russia; karpovich.gleb@yandex.ru; http://orcid.org/:0000-0003-0982-6952
Irina V. Kuimova, MD; Associate Professor; Professor, Department of Infectious Diseases; Novosibirsk State Medical University, Novosibirsk, Russia; kuimova_ira@mail.ru; http://orcid.org/:0000-0003-4727-1636
Yulia S. Serova, Infectiologist, Children’s City Hospital Three, Novosibirsk, Russia; dgkb3@nso.ru; http://orcid.org/0000-0003-2521-4761


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