Русский
Microbiological monitoring of patients in the infectious intensive care unit
DOI: https://dx.doi.org/10.18565/epidem.2025.15.1.67-73
Orlova O.A., Gusarov V.G., Kamyshova D.A., Petrova L.V., Semenenko T.A.
1) N.I. Pirogov National Medical and Surgical Center, Ministry of Health of the Russia, Moscow, Russia; 2) N.F. Gamaleya National Research Center for Epidemiology and Microbiology, Ministry of Health of the Russia, Moscow, Russia; 3) Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
Materials and methods. An analysis of microbiological monitoring data was performed for 88 patients diagnosed with novel coronavirus infection who were admitted to ICU. Microbiological studies were performed using the standard methodology.
Results. Before admission to the ICU, 27.3% of patients received antimicrobial therapy. The frequency of microbial colonization of various bioloci in patients at admission to the ICU was 93.8% in the contents of the lower respiratory tract, 54.1% in urine, and 35.0% in blood. Normal commensals of the oral cavity and urinary tract were mainly isolated in the contents of the lower respiratory tract and urine. A significant content of Candida fungi was noted – 24.0 and 13.6%, respectively. Staphylococcus spp. were isolated in the blood of patients at admission to the ICU in 71.4% of cases, and Actinomyces spp. In 19.0%. Dynamically, an increase in the frequency of fungal isolation from all loci of patients was noted. Already at admission, some patients (7.6–38.1%) were contaminated with antibiotic-resistant microorganisms; dynamically, a decrease in the isolation of antibiotic-resistant microorganisms isolated from the contents of the lower respiratory tract and blood was noted.
Conclusion. Microbiological monitoring is necessary in the ICU, since it provides early diagnosis of healthcare-associated infections, monitoring the dynamics of the epidemic process and timely prescription of rational antimicrobial therapy.
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About the Autors
Oksana A. Orlova, MD, Head, Еpidemiology Department, N.I. Pirogov National Medical and Surgical Center, Ministry of Health of the Russia; Senior Researcher, Laboratory of Opportunistic Infections, N.F.Gamaleya National Research Centre for Epidemiology and Microbiology, Ministry of Health of the Russia; Leading Researcher, Laboratory of Healthcare-Associated Infections, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; oksana_orlova@bk.ru; https://orcid.org/0000-0002-6701-1252
Vitaly G. Gusarov, МD, Associate Professor, Chief Physician of the Hospital, N.I. Pirogov National Medical and Surgical Center, Ministry of Health of the Russia; Head, Department of Anesthesiology and Resuscitation, Institute for Advanced Medical Training, N.I. Pirogov National Medical and Surgical Center, Ministry of Health of the Russia; Moscow, Russia; gusarovvg@pirogov-center.ru; https://orcid.org/0000-0002-2900-1459
Darya A. Kamyshova, Clinical Pharmacologist, Head, Department of Clinical Pharmacology, N.I. Pirogov National Medical and Surgical Center, Ministry of Health of the Russia; Assistant Professor, Department of Internal Medicine, Institute for Advanced Medical Training, N.I. Pirogov National Medical and Surgical Center, Ministry of Health of the Russia, Moscow, Russia; kamyshovada@pirogov-center.ru; https://orcid.org/0000-0003-3084-9294
Ludmila V. Petrova, Bacteriologist, Head, Laboratory of Microbiology, N.I. Pirogov National Medical and Surgical Center, Ministry of Health of the Russia, Moscow, Russia; petrovalv@pirogov-center.ru; https://orcid.org/0000-0001-6221-9743
Professor Tatiana A. Semenenko, MD, Head, Epidemiology Department, N.F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of the Russia; Рrofessor, Department of Infectology and Virology, Institute of Professional Education, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russia (Sechenov University), Moscow, Russia; semenenko@gamaleya.org; https://orcid.org/0000-0002-6686-9011
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