A case of septic salmonellosis with damage to the central nervous system in hiv-infected patient


DOI: https://dx.doi.org/10.18565/epidem.2023.13.4.87-92

Kapustin D.V., Krasnova E.I., Khokhlova N.I., Demchenko S.V., Shishkova O.M., Kriklivaya N.P., Nalimova T.M., Gashnikova N.M., Pozdnyakova L.L.

1) Novosibirsk State Medical University, Novosibirsk, Russia; 2) City Infectious Diseases Clinical Hospital № 1, Novosibirsk, Russia; 3) State Scientific Center for Virology and Biotechnology «Vector» of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Koltsovo, Russia
Objective. Analysis of a case of septic salmonellosis with damage to the central nervous system in a HIV infected patient.
Materials and methods. The data of clinical, laboratory and instrumental diagnostic methods in HIV-infected patient with a septic salmonellosis, who was being treated at the City Infectious Diseases Clinical Hospital № 1 in Novosibirsk, were analyzed.
Results. The clinical course of salmonellosis against the background of severe immunodeficiency was characterized by a rapid transition from the gastrointestinal to the septic form with the development of damage to the central nervous system on the 5th day of hospitalization. The choice of antibacterial therapy tactics was complicated by the presence of resistance of blood-isolated S. enteritidis to ciprofloxacin and amikacin. Despite the resumption of antiretroviral therapy and ongoing antibacterial (taking into account sensitivity) and pathogenetic therapy, the patient’s condition could not be stabilized. Irreversible damage by S. enteritidis to the central nervous system and kidneys against the background of severe immunodeficiency led to severe impairment of vital functions followed by death.
Conclusion. When diagnosing salmonellosis in patients with HIV infection, awareness in terms of the high risk of developing generalized forms of the disease is necessary. In real clinical practice, a study of the drug resistance profile of Salmonella is required to select effective antibacterial therapy.
Keywords: septic form, AIDS, salmonellosis, immunodeficiency, HIV infection
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About the Autors

Dmitry V. Kapustin, Cand. Med. Sci., Assistant, Department of Infectious Diseases, Novosibirsk State Medical University, Russia, Novosibirsk. dmitrij_kapustin_1991@inbox.ru; https://orcid.org/ 0000-0002-7060-4710
Professor Elena I. Krasnova, МD, Head, Department of Infectious Diseases, Novosibirsk State Medical University, Novosibirsk, Russia; krasnova-inf@rambler.ru; https://orcid.org/0000-0003-3168-9309
Natalia I. Khokhlova, Cand. Med. Sci., Associate Professor, Associate Professor, Department of Infectious Diseases, Novosibirsk State Medical University, Novosibirsk, Russia, Novosibirsk.talitas@bk.ru; https://orcid.org/0000-0003-4497-3173
Svetlana V. Demchenko, Infectious Disease Doctor, Infectious Disease Doctor, City Infectious Diseases Clinical Hospital № 1, Novosibirsk, Russia; gikb1@yandex.ru
Olga M. Shishkova, Pathologist, City Infectious Diseases Clinical Hospital № 1; Novosibirsk, Russia; gikb1@yandex.ru
Nadezhda P. Kriklivaya, Research Assistant, Department of Retroviruses, State Scientific Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Koltsovo, Novosibirsk Region, Russia; kriklivaya_np@vector.nsc.ru
Tatiana M. Nalimova, Junior Researcher, Department of Retroviruses, Postgraduate Student, State Scientific Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Koltsovo, Novosibirsk Region, Russia; https://orcid.org/0000-0001-8408-0930
Natalya M. Gashnikova, Cand. Med. Sci., Head, Department of Retroviruses, State Scientific Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being Koltsovo, Novosibirsk Region, Russia; ngash@vector.nsc.ru; https://orcid.org/0000-0002-0891-0880
Larisa L. Pozdnyakova, Cand. Med. Sci., Chief Physician, City Infectious Diseases Clinical Hospital № 1, Novosibirsk, Russia; gikb1@yandex.ru


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