The clinical and epidemiological characteristics of patients with potentially HPV-related head and neck cancers: results of a sampling study


DOI: https://dx.doi.org/10.18565/epidem.2021.11.2.63-8

Belyakova E.N., Sekacheva M.I., Lopukhov P.D., Briko N.I.

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia
Objective. To investigate the clinical and epidemiological characteristics of patients with potentially HPV-related head and neck cancers on the basis of the results of a sampling study.
Subjects and methods. The investigators retrospectively studied data from 295 patients with head and neck cancers who had sought medical care at University Clinical Hospital One, Sechenov University, in 2018 to 2020. The information was obtained applying the inpatient medical records (Form 003/y) and the questionnaire method. Analytical and statistical methods were used to analyze and process the material.
Results. HPV 16 was most frequently detected in 75.7% [56.7–89.1%] of patients with oral and pharyngeal cancers and in 25% [4.7–63.2%] of those with laryngeal cancer. There was a significant preponderance of patients with Stages III and IV. Among the deceased, the proportion of people with HPV-positive head and neck cancers accounted for 10.0% [2.8-24.8%]. The proportion of low-grade squamous cell carcinoma was 41.2% [33.9–48.7%].
Conclusion. The identified clinical and epidemiological characteristics of patients with potentially HPV-related head and neck cancers should contribute to the further improvement of the existing prevention programs for this condition and to the development of new ones.

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About the Autors


Ekaterina N. Belyakova, Postgraduate Student, I.M. Sechenov First Moscow State Medical University (I.M. Sechenov University), Ministry of Health of Russia, Moscow, Russia; beliackova.caterina@yandex.ru; https://orcid.org/0000-0003-0210-1668
Professor Marina I. Sekacheva, MD, Director, Institute of Cluster Oncology; Head, «OncoTarget» Personalized Oncology Center, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia; sekacheva_m_i@ staff.sechenov.ru; https://orcid.org/0000-0003-0015-7094
Platon D. Lopukhov, PhD, Associate Professor, Department of Epidemiology and Evidence-Based Medicine, I.M. Sechenov First Moscow State Medical University (I.M. Sechenov University), Ministry of Health of Russia, Moscow, Russia; pl2211@yandex.ru; https://orcid.org/0000-0002-0872-221
Professor Nikolay I. Briko, MD, Academician of the Russian Academy of Sciences, Honored Scientist of the Russian Federation; Director, F.F. Erisman Institute of Public Health; Head, Department of Epidemiology and Evidence-Based Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia; nbrico@mail.ru; http://orcid.org/0000-0002-6446-2744


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