Русский
HIV-1 genetic characteristics in patients having experienced virological failure of therapy in the Kyrgyz Republic in 2017–2018
DOI: https://dx.doi.org/10.18565/epidem.2020.10.3.105-11
Lapovok I.A., Saleeva D.V., Lopatukhin A.E., Kirichenko A.A., Murzakova A.V., Bekbolo-tov A.A., Iskanova B.M., Narnatova E.B., Akmatova Zh.K., Asybalieva N.A., Kireev D.E.
1) Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 2) Republican AIDS Center of Ministry of Health of Kyrgyz Republic, Bishkek, Kyrgyzstan; 3) Osh AIDS Center of Ministry of Health of Kyrgyz Republic, Osh, Kyrgyzstan.
Materials and methods. Рlasma samples (n = 100) was collected, HIV-1 pol-gene nucleotide sequences were studied, the subtype of the virus in the samples was determined, as well as the structure and level of drug resistance of HIV-1.
Results. It was determinate the domination of HIV-1 recombinant variant CRF63_02A1 (in 56% of samples) and sub-subtype A6 ((in 56% of samples) in Kyrgyzstan. At the same time, there were revealed the cases of infection with a rare genetic form of HIV-1, close to CRF94_cpx and CRF95_02B. It was found a high frequency of resistance mutations to drugs included in the main treatment regimens used in the country: to EFV and NVP (in 48 and 50% of samples, respectively) and to FTC and 3TC (in 39% of samples).
Conclusion. The high drug resistance frequency to the main ART regimen drugs in patients with high treatment adherence indicates the need for further drug resistance monitoring in the country, including among patients without treatment experience and who are just starting it.
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About the Autors
Ilya A. Lapovok, Cand. Biol. Sci., Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: i_lapovok@mail.ru; ORCID: https://orcid.org/0000-0002-6328-1415
Daria V. Saleeva, Laboratory Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: dasha_ saleeva@inbox.ru; ORCID: https://orcid. org/0000-0002-5870-5594
Aleksey E. Lopatukhin, Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: a.lopatukhin@gmail.com; ORCID: https://orcid.org/0000-0002-2826-699X
Alina A. Kirichenko, Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: kotova-kirichenko@mail.ru; ORCID: http://orcid.org/0000-0002-7116-0138
Anastasia V. Murzakova, Researcher, Central Research Institute of Epidemiology, Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: murzakova_a.v@mail.ru; ORCID: https://orcid. org/0000-0002-1390-8021
Aibek A. Bekbolotov, Deputy Director, Republican AIDS Center, Ministry of Health of the Kyrgyz Republic, Bishkek, Kyrgyzstan; e-mail: aibek_0001@mail.ru; ORCID: https://orcid.org/0000-0001-9931-3311
Baarnisa M. Iskanova, Laboratory Doctor, Republican AIDS Center, Ministry of Health of the Kyrgyz Republic, Bishkek, Kyrgyzstan; e-mail: i.barnisa@hotmail.com; ORCID: https:// orcid.org/0000-0002-2493-1788
Elmira B. Narmatova, Chief Physician, Osh Regional Center for AIDS Prevention and Control, Ministry of Health of the Kyrgyz Republic, Osh, Kyrgyzstan; e-mail: elmira.narmatova@yandex.ru; ORCID: https://orcid.org/0000-0001-9263-0525
Zhyldyz K. Akmatova, Epidemiologist, Republican AIDS Center, Ministry of Health of the Kyrgyz Republic, Bishkek, Kyrgyzstan; e-mail: zhyldyz_akmatova@mail.ru; ORCID:https://orcid.org/0000-0003-4890-3690
Nazgul A. Asybalieva, Epidemiologist, Republican AIDS Center, Ministry of Health of the Kyrgyz Republic, Bishkek, Kyrgyzstan; e-mail: nazgul-asybaliev@mail.ru; ORCID: https://orcid.org/0000-0002-6715-3592
Dmitry E. Kireev, Cand. Biol. Med., Researcher, Central Research Institute of Epidemiology, Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: dmitkireev@yandex.ru; ORCID: https://orcid.org/ 0000-0002-7896-2379
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