Русский
Quality of antiretroviral therapy in 2008–2018
DOI: https://dx.doi.org/10.18565/epidem.2020.10.3.87-93
Yurin O.G., Ladnaia N.N., Kozyrina N.V., Kravchenko A.V., Narsia R.S., Sokolova E.V., Dementyeva L.A., Pokrovsky V.V.
Federal Research and Guidance Center for AIDS Prevention and Control, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
Materials and methods. The paper analyzes the data on ART, which were obtained from all subjects of Russia in the period of 2008-2018 during a special study and from the reporting forms of the Ministry of Health of Russia and the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being.
Results. In the period of 2008–2018, ART coverage for people living with HIV increased from 10.9 to 38.4%. By the end of 2018, the viral load was below the detection threshold in 73.2% of those receiving ART, which was less than its target value (90%). The proportion of patients starting ART with a CD4+ lymphocyte count of <200 cells/μl decreased from 43.6% in 2008 to 16.6% in 2018. That of patients receiving ART regimens including non-nucleoside reverse transcriptase inhibitors rose from 40.1% in 2013 to 68.1% in 2018. Among the patients who initiated ART in 2018, by the end of the year 17.5% stopped it (of them 46.4% did due to death). Of the remaining on ART, its regimen was changed by 20.7% (of them, 40.8 and 19.8% did because of side effects and its inefficiency, respectively).
Conclusion. The problem of insufficient ART coverage and late initiation remains relevant. The frequency of ART discontinuation and treatment interruptions remains high. It is expedient to use drugs with a high resistance barrier and good tolerance when starting ART.
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About the Autors
Oleg G. Yurin, МD, Leading Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: oleg_gerald@mail.ru; ORCID: htpp://orcid.org/0000-0003-1930-7486
Natalia N. Ladnaia, Cand. Biol. Sci., Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; е-mail: ladnaia@hotmail.com; ORCID: htpp://orcid.org/0000-0003-2994-151X
Prof. Aleksey V. Kravchenko, МD, Leading Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: alexey-kravtchenko@yandex.ru; ORCID: http://orcid.org/0000-0001-7857-3763
Nadezhda V. Kozyrina, Cand. Med. Sci., Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; е-mail: nad-kozyrina@yandex.ru; ORCID: htpp://orcid.org/0000-0001-5134-0054
Roza S. Narsia, Deputy Head for Economic Affairs and Medical Personnel Management, Specialized Research Department for AIDS Epidemiology and Prevention, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; е-mail: rnarsiya @mail.ru
Ekaterina V. Sokolova, Cand. Med. Sci., Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: ekaterinasokolova007@rambler.ru, ORCID: http://orcid.org/0000-0002-2001-8772
Larisa А. Dementyeva, Epidemiology Specialist, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; е-mail: Dementeva_la@gsen.ru
Prof. Vadim V. Pokrovsky, Academician of the Russian Academy of Sciences MD, Head, HIV Department, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: pokrovsky.vad@yandex.ru; ORCID: http://orcid.org/0000-0002-9514-7288
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