Biomarkers of liver fibrosis and cirrhosis in chronic hepatitis C. Clinical and pathophysiological aspects


DOI: https://dx.doi.org/10.18565/epidem.2024.14.4.94-100

Tereshkin N.A., Makashova V.V., Ponezheva Z.B., Omarova Kh.G.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
The review is devoted to the relevance of studying serological biological markers in chronic hepatitis C. Currently, it is important to develop markers for the early diagnosis of liver fibrosis and cirrhosis. The article demonstrates the possibilities of using osteopontin and hepatocyte growth factor as biomarkers of liver fibrosis and cirrhosis. Studies indicating the possibility of using these substances as targets for antifibrotic therapy are presented.

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About the Autors


Nikita A. Tereshkin, PhD student, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; nteryoshkin@gmail.com; https://orcid.org/0009-0002-3541-4150
Professor Vera V., Makashova, MD, Leading Researcher, Clinical Department of Infectious Pathology, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; veramakashova@yandex.ru; https://orcid.org/0000-0002-0982-3527
Zhanna B., Ponezheva, MD, Head, Clinical Department of Infectious Pathology, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; doktorim@mail.ru; https://orcid.org/0000-0002-6539-4878
Khadizhat G. Omarova, Cand. Med, Sci., Head, Clinical Research Department, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; omarova71@inbox.ru; https://orcid.org/0000-0002-9682-2230


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