Русский
Spread of leptospirosis in non-endemic territory
DOI: https://dx.doi.org/10.18565/epidem.2024.14.4.77-83
Breneva N.V., Budaeva S.E., Ostapenko N.A., Belyaeva L.I., Faizullina N.M., Kozlova I.I., Nechaeva E.E., Kudryavtseva I.V., Solovieva M.G., Balakhonov S.V.
1) Irkutsk Anti-Plague Research Institute of Siberia and the Far East, Irkutsk, Russia; 2) Center for Hygiene and Epidemiology in the Khanty-Mansiysk Autonomous Okrug - Yugra, Khanty-Mansiysk, Russia; 3) Office of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being in the Khanty-Mansi Autonomous Okrug – Yugra, Khanty-Mansiysk, Russia
Materials and methods. A retrospective analysis of the incidence of leptospirosis in humans and animals, a comprehensive survey of the population (n = 66), argicultural and domestic animals (n = 50), small mammals and birds (n = 1292) was conducted, operational information on patients with leptospirosis and contacts at risk of infection was obtained.
Results. Over the past 10 years, the Yugra Veterinary Service reported five farms with unfavorable conditions for leptospirosis in cattle. Isolated cases of human disease were registered in 1995 and 2008-2010. After a long period of epidemiological well-being, an imported case of leptospirosis was detected in 2021. Since 2019, there has been a significant increase in the epizootic activity of natural foci of leptospirosis in Yugra; in the summer-autumn season of 2022, the infection rate of carriers according to PCR results was 13.2 ± 3.3%. Specific antibodies were detected in 86.5 ± 5.6% of cases in deer, which, during nomadic grazing, could be infected in several natural foci at once. Circulation of leptospira of the Australis, Autumnalis, Bataviae, Canicola, Grippotyphosa, Hebdomadis, Icterohaemorrhagiae, Sejroe, Tarassovi serogroups was detected.
Conclusion. The season of detection of sick people (Novemb–March) indicates infection in anthropurgic foci. The results of the studies indicate a wide distribution of leptospirosis among deer. The seroscape of specific anti-leptospirosis antibodies in animals in anthropurgic and natural foci confirms possible cross-infection.
Literature
1. Коренберг Э.И., Помелова В.Г., Осин Н.С. Природноочаговые инфекции, передающиеся иксодовыми клещами. Под ред. Гинцбурга А.Л., Злобина В.Н. М.: Наука, 2013. 465 с. Korenberg E.I., Pomelova V.G., Osin N.S. [Natural focal infections transmitted by ixodic ticks]. Gintsburg A.L., Zlobin V.N., eds. Moscow: Nauka, 2013. 465 p. (In Russ.). 2. Кучерук В.В. Избранные труды по природной очаговости болезней. Сост.: Э.И. Коренберг, Л.А. Хляп. М.: РУСАКИ, 2006. 306 с. Kucheruk V.V. [Selected works on natural foci of diseases]. Comp.: E.I. Korenberg, L.A. Khlyap. Moscow: RUSAKI, 2006, 306 p. (In Russ.). 3. Малхазова С.М., ред. Медико-географический атлас России «Природноочаговые болезни». М.: Географический факультет МГУ, 2015. 208 с. Malkhazova S.M., ed. [Medico-geographical atlas of Russia «Natural focal diseases”] Moscow: Geographical Faculty of Moscow State University, 2015. 208 p. (In Russ.). 4. Малхазова С.М., Миронова В.А. Природноочаговые болезни в России. Природа 2017: (4): 37–47. Malkhazova S.M., Mironova V.A. [Natural focal diseases in Russia] Nature 2017: (4): 37–47. (In Russ.). 5. Городин В.Н., Мойсова Д.Л., Бахтина В.А., Зотов С.В. Тренды современного лептоспироза. Эпидемиол. инфекц. бол. 2018; 23(2): 93–100. DOI: 10.18821 /1560-9529-2018-23-2-93-100 Gorodin V.N., Moisova D.L., Bakhtina V.A., Zotov S.V. [Trends of modern leptospirosis]. Epidemiology and Infectious Diseases. 2018; 23(2): 93–100. (In Russ.). DOI: 10.18821 /1560-9529-2018-23-2-93-100 6. Онищенко Г.Г., Балахонов С.В., ред. Обеспечение санитарно-эпидемиологического благополучия населения при ликвидации последствий наводнения на Дальнем Востоке. Новосибирск: Наука-Центр, 2014. 648 с. Onishchenko G.G., Balakhonov S.V., eds. [Ensuring the sanitary and epidemiological well-being of the population during the elimination of the consequences of floods in the Far East]. Novosibirsk: Science Center, 2014. 648 p. (In Russ.). 7. Ананьина Ю.В. Лептоспирозы в Российской Федерации: современные особенности эпидемического проявления природных и техногенных очагов. Ветеринарная патология 2004; (4): 54–57. Ananyina Yu.V. [Leptospirosis in the Russian Federation: modern features of epidemic manifestations of natural and technogenic foci]. Veterinary pathology 2004; (4): 54–57. (In Russ.). 8. Токаревич Н.К., Стоянова Н.А. Эпидемиологические аспекты антропогенного влияния на эволюцию лептоспирозов. Инфекция и иммунитет 2011; 1(1): 67–76. Tokarevich N.K., Stoyanova N.A. [Epidemiological aspects of anthropogenic influence on the evolution of leptospirosis]. Infection and Immunity 2011; 1(1): 67–76. (In Russ.). 9. Habus J., Persic Z., Spicic S., Vince S., Stritof Z., Milas Z. et al. [New trends in human and animal leptospirosis in Croatia, 2009–2014]. Аcta Trop. 2017: 168: 1–8. DOI: 10.1016/j.actatropica.2017.01.002 10. Самсонова А.П., Петров Е.М., Савельева О.В., Иванова А.Е., Шарапова Н.Е. Анализ документированных результатов исследования сывороток крови больных, подозрительных на заболевание лептоспирозами, в реакции микроагглютинации. Инфекция и иммунитет 2022; 12(5): 875–90. DOI: 10.15789/2220-7619-ATD-1758 Samsonova A.P., Petrov E.M., Savelyeva O.V., Ivanova A.E., Sharapova N.E. [Analysis of documented results of the study of blood sera of patients suspected of leptospirosis in the reaction of microagglutination]. Infection and Immunity 2022; 12(5): 875–90. (In Russ.). DOI: 10.15789/2220-7619-ATD-1758 11. Громов И.М., Поляков И.Я. Полевки (Microtinae). В серии: Фауна СССР. Млекопитающие. Т. III, вып. 8. Л.: Наука, 1977. 504 с. Gromov I.M., Polyakov I.Ya. [Voles (Microtinae)]. In the series: [Fauna of the USSR. Mammals]. Vol. III, Issue 8. Leningrad: Science, 1977. 504. p. (In Russ.). 12. Башенина Н.В., ред. Европейская рыжая полевка. М.: Наука, 1981. 352 с. Bashenina N.V., ed. [European red vole]. Moscow: Science, 1981. 352 p. (In Russ.). 13. Онищенко Г.Г., Кутырев В.В. (ред.). Лабораторная диагностика опасных инфекционных болезней: Практическое руководство. Изд. 2-е, перераб. и доп. М.: ЗАО «Шико», 2013. 560 с. Onishchenko G.G., Kutyrev V.V. eds. [Laboratory diagnostics of dangerous infectious diseases: Practical guide]. Moscow: Shiko, 2013. 560 p. (In Russ.). 14. Закс Л. Статистическое оценивание. Пер. с нем. В.Н. Варыгина. М.: : Статистика, 1976. 598 с. Zachs L. [Statistical estimation]. Translated from German by V.N. Varygin. Moscow: Statistics, 1976. 598 p. (In Russ.). 15. Макеев С.М., Марамович А.С., Кондаков А.А., Чернявский В.Ф., Кузнецов А.П. Эпидемиологический мониторинг за лептоспирозами в регионах Сибири и Дальнего Востока. Бюллетень ВСНЦ СО РАМН. Иркутск, 2004; 2(1): 113–6. Makeev S.M., Maramovich A.S., Kondakov A.A., Chernyavskу V.F., Kuzneczov A.P. [Epidemiological monitoring of leptospirosis in the regions of Siberia and the Far East]. Bulletin of the All-Russian Scientific Research Center of the Russian Academy Russian Academy of Medical Sciences. Irkutsk, 2004; 2(1): 113–6. (In Russ.) 16. Dietrich M., Muhldorfer K., Tortosa P., Markotter W. Leptospira and bats: story of an emerging friendship. PLoS Pathogens. 2015; 11(11): e1005176. DOI: 10.1371/journal.ppat.1005176 17. Ананьина Ю.В., Петров Е.М. Лептоспирозы в России: этиологическая структура и современная эпидемиология. РЭТ-ИНФО 2006; 57(1): 8–10. Ananyina Yu.V., Petrov E.M. [Leptospirosis in Russia: etiological structure and modern epidemiology]. Rat-Info 2006; 57(1): 8–10. (In Russ.). 18. Haake D.A., Levett P.N. Leptospirosis in Humans. Curr. Top. Microbiol. Immunol. 2015: 387: 65–97. DOI: 10.1007/978-3-662-45059-8_5. 19. Бренева Н.В., Корзун В.М., Мельцов И.В., Уманец А.А., Кузин Д.Ю., Мусатов Ю.С. и др. Влияние специфической профилактики лептоспирозов на эпидемический процесс. Эпидемиология и Вакцинопрофилактика 2019; 18(1): 88–95. DOI: 10.31631/2073-3046-2019-18-1-88-95. Breneva N.V., Korzun V.M., Meltsov I.V., Umanets A.A., Cusin D.Yu., Musatov Yu.S. et al. [The effect of specific prevention of leptospirosis on the epidemic process. Epidemiology and Vaccination Prevention]. 2019; 18(1): 88–95. (In Russ.). DOI: 10.31631/2073-3046-2019-18-1-88-95 20. Соболева Г.Л., Ананьина Ю.В., Непоклонова И.В. Актуальные вопросы лептоспироза людей и животных. Российский ветеринарный журнал 2017: 8: 13–17. Soboleva G.L., Ananyina Yu.V., Nepoklonova I.V. [Topical issues of human and animal leptospirosis]. Russian Veterinary Journal 2017: 8: 13–17. (In Russ.).
About the Autors
Natalya V. Brenyova, Cand. Med. Sci., Leading Researcher, Epidemiology Department, Irkutsk Anti-Plague Research Institute, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Irkutsk, Russia; nbreneva@list.ru; https://orcid.org/0000-0002-9207-7536
Sofia E. Budaeva, Junior Researcher, Department of Epidemiology, Irkutsk Anti-Plague Research Institute, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Irkutsk, Russia; inst.4ever.youu@yandex.ru; https://orcid.org/0000-0003-3588-8145
Nadezhda A. Ostapenko, Head, Department of Epidemiological Surveillance, Center for Hygiene and Epidemiology in the Khanty-Mansiysk Autonomous Okrug-Yugra, Khanty-Mansiysk, Russia; Ostapenko-na86@yandex.ru; https://orcid.org/0000-0002-5643-6765
Lyudmila I. Belyaeva, Head, Department of Epidemiological Surveillance, Branch of the Center for Hygiene and Epidemiology in Khanty-Mansiysk Autonomous Okrug-Yugra in Surgut, Surgut District and Kogalym, Surgut, Russia; sur_belyaevali@xmao.su; https://orcid.org/0009-0000-8781-9032
Nazira M. Fayzullina, Head, Department of Surveillance over Natural Focal and Especially Dangerous Diseases, Center for Hygiene and Epidemiology in Khanty-Mansiysk Autonomous Okrug-Yugra, Khanty-Mansiysk, Russia; otchethmao@xmao.su; https://orcid.org/0009-0009-0574-7799
Irina I. Kozlova, Chief Physician, Center for Hygiene and Epidemiology in Khanty-Mansiysk Autonomous Okrug–Yugra, Khanty-Mansiysk, Russia; iriv_ko@mail.ru; https://orcid.org/0000-0002-3345-1786
Elena E. Nechayeva, Head, Department of Epidemiological Surveillance and Sanitary Protection of the Territory, Office of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being in Khanty-Mansiysk Autonomous Okrug–Yugra, Khanty-Mansiysk, Russia; nechaeva_ee@86. rospotrebnadzor.ru; https://orcid.org/0009-0000-2307-451
Inna V. Kudryavtseva, Deputy Head, Office of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being for Khanty-Mansiysk Autonomous Okrug–Yugra Khanty-Mansiysk, Russia; kudryavtseva_iv@86.rospotrebnadzoг.ru; https://orcid.org/0009-0002-1600-1254
Maya G.Solovyova, Head, Office of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being for Khanty-Mansiysk Autonomous Okrug–Yugra Khanty-Mansiysk, Russia; solovieva_mg@86.rospotrebnadzor.ru; https://orcid.ogg/0009-0000-4848-3417
Professor Sergey V. Balakhonov, MD, Director, Irkutsk Research Anti-Plague Institute, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Irkutsk, Russia; adm@chumin.irkutsk.ru; https://orcid.org/0000-0003-4201-5828
Similar Articles
