Diversity of streptococcus species isolated in the departments of purulent surgery and coloproctology of a multidisciplinary hospital and their antibiotic resistance


DOI: https://dx.doi.org/10.18565/epidem.2024.14.2.49-55

Kaytukov A.O., Glushkova E.V., Dyment E.A., Salmina V.G., Kryzhanovsky T.A., Orlova O.E., Briko N.I.

1) Sechenov University, Moscow, Russia; 2) L.A. Vorokhobova City Clinical Hospital № 67 of the Moscow Healthcare Department, Moscow, Russia
Objective. Determination of the frequency of occurrence and characteristics of sensitivity to antibiotics of different Streptococcus species isolated from patients in the departments of purulent surgery and coloproctology of a multidisciplinary hospital in Moscow.
Materials and methods. An epidemiological observational descriptive continuous retrospective study using data from patients of departments of purulent surgery (n = 2094) and coloproctology (n = 1933) aged 18 years and older for 2017–2022 was conducted. The sensitivity to antibiotics of 1208 streptococcal cultures isolated in the department of purulent surgery and 827 cultures obtained in the department of coloproctology was analyzed. Antibiotic susceptibility was determined using microbiological analyzers BD Phoenix M50 and VITEK 2XL in accordance with EUCAST and CLSI recommendations.
Results. In the department of purulent surgery, Streptococcus pyogenes (28,53%), Streptococcus agalactiae (22,0%), Streptococcus anginosus (16,49%) were isolated statistically significantly more often; in the department of coloproctology – S. anginosus (41,66%), Streptococcus constellatus (15,99%), S. agalactiae (14,54%). A significant proportion of S. agalactiae cultures showed resistance to tetracycline (80,32%) and clindamycin (41,13%). In the department of purulent surgery, S. agalactiae resistance to erythromycin increased from 15,4 to 38,3% from 2019 to 2021, in the department of coloproctology – from 16,67 to 38,46%.
Conclusion. The results obtained revealed significant differences in the antimicrobial resistance of streptococci and showed the inappropriateness of using tetracycline and erythromycin to treat patients in the department of purulent surgery.

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About the Autors


Azamat O. Kaytukov, Postgraduate Student, Epidemiology and Evidence-Based Medicine Department, F.F. Erisman Institute of Public Health, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russia (Sechenov University). Moscow, Russia; dodta1510@mail.ru; https://orcid.org/0000-0003-4399-081X
Ekaterina V. Glushkova Cand. Med.Sci., Associate Professor, Epidemiology and Evidence-Based Medicine Department, F.F. Erisman Institute of Public Health, I.M. Sechenov First Moscow State Medical University, Ministry of Healthcare of the Russian Federation (Sechenov University). Moscow, Russia; glushkova_e_v@staff.sechenov.ru; https://orcid.org/0000-0001-6997-7598
Elizaveta A. Dyment, 6th year Student at the Medical and Preventive Faculty, I.M. Sechenov First Moscow State Medical University, Ministry of Healthcare of the Russian Federation (Sechenov University). Moscow, Russia; elizavetadyment@mail.ru; https://orcid.org/0009-0001-1048-5844
Vasiliу G. Kryzhanovskу, Deputy Chief Physician for Sanitary and Epidemiological Issues, L.A. Vorokhobova City Clinical Hospital № 67 of the Moscow Healthcare Department,. Moscow, Russia; kryzhanv@yandex.ru
Tatiana A. Salmina, Head, Epidemiology Department, L.A. Vorokhobova City Clinical Hospital № 67 of the Moscow Healthcare Department, Moscow, Russia; sta_1172@mail.ru
Olga E. Orlova, Cand. Biol. Sci., Head, Microbiological Laboratory, L.A. Vorokhobova City Clinical Hospital № 67 of the Moscow Healthcare Department, Moscow, Russia; o.e.orlova@yandex.ru; https://orcid.org/0000-0001-7210-1116
Professor Nikolay I. Briko, Academician, Russian Academy of Sciences. MD, Head, Department of Epidemiology and Evidence-Based Medicine; Director, F.F. Erisman Institute of Public Health, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russia (Sechenov University); Moscow, Russia; nbrico@mail.ru; https://orcid.org/0000-0002-6446-2744


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