Русский
Clinical and laboratory characteristics of Q fever in the Novosibirsk region
DOI: https://dx.doi.org/10.18565/epidem.2024.14.2.38-44
Vyazhevich A.N., Krasnova E.I., Bondarenko E.I., Krinitsyna E.V., Khokhlova N.I., Pozdnyakova L.L., Provorova V.V., Kolpakova T.A., Poddubnaya L.V.
1) Novosibirsk State Medical University, Novosibirsk, Russia; 2) City Infectious Diseases Clinical Hospital № 1, Novosibirsk, Russia; 3) «Vector-Best», Novosibirsk, Russia
Material and methods. 830 patients hospitalized with suspected infectious diseases transmitted by ticks in the spring-summer period 2018–2022 were examined. To confirm the results of PCR analysis, positive samples containing C. burnetii DNA were amplified using fragments of the IS1111 genes and the heat shock protein B gene (htpB), followed by their sequencing. The presence of class G immunoglobulins to C.burnetii in blood serum samples of patients was detected using ELISA.
Results. All patients with Q fever had intoxication syndrome with febrile fever, 86% had hepatitis with mild-to-moderate cytolysis syndrome; 2 (14.3%) patients developed serous meningitis. Pneumonia was diagnosed in 1 (7.1%) case.
Conclusion. Diagnosis of Q fever due to the polymorphism of the clinical course is impossible without laboratory confirmation. Identification of cases of the disease in the Novosibirsk region during a comprehensive clinical and laboratory study dictates the need to include early diagnosis of Q fever in the list of mandatory tests in patients with tick bites, which is of great practical importance for timely and adequate therapy.
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About the Autors
Anna N. Vyazhevich, Assistant, Department of Infectious Diseases, Novosibirsk State Medical University; Infectious Disease Doctor, City Infectious Diseases Clinical Hospital №. 1, Novosibirsk, Russia; dr.anna.oleynik@mail.ru; https://orcid.org/0000-0002-6387-3939
Professor Elena I. Krasnova, MD, Head, Department of Infectious Diseases, Novosibirsk State Medical University; Infectious Disease Doctor, City Infectious Diseases Clinical Hospital №. 1, Novosibirsk, Russia; krasnova-inf@list.ru; https://orcid.org/0000-0003-2625-5442
Evgeny I. Bondarenko, Cand. Med. Sci., Researcher, PCR laboratory, «Vector-Best», Novosibirsk. Russia; bondarenko_e@vector-best.ru; https://0000-0002-4699-9548
Elvira V. Krinitsyna, Senior Biotechnologist, Department of hepatitis C ELISA, «Vector-Best», Novosibirsk, Russia; krinitsyna@vector-best.ru; https://orcid.org/0000-0003-3979-6619
Natalya I. Khokhlova, Cand. Med. Sci., Associate Professor, Department of Infectious Diseases, Novosibirsk State Medical University; Infectious Disease Doctor, City Infectious Diseases Clinical Hospital №. 1, Novosibirsk, Russia; talitas@bk.ru; https://orcid.org/0000-0003-4497-3173
Larisa L. Pozdnyakova, Cand. Med. Sci., Doctor of the Highest Qualification Category, Chief Physician, City Infectious Diseases Clinical Hospital №. 1, Novosibirsk, Russia; gikb1@nso.ru
Veronika V. Provorova. Cand. Med. Sci., Associate Professor, Department of Infectious Diseases, Novosibirsk State Medical University; Doctor of the Highest Qualification Category, Infectious Disease Doctor, City Infectious Diseases Clinical Hospital №. 1, Novosibirsk, Russia; provorova.ydif@mail.ru; https://orcid.org/0000-0002-3475-9934
Tatiana A. Kolpakova, MD, Professor, Department of Phthisiopulmonology, Novosibirsk State Medical University, Novosibirsk, Russia; t.a.Kolpakova@yandex.ru; https://orcid.org/0000-0001-9718-2020
Lyudmila V. Poddubnaya, MD, Professor, Department of Phthisiopulmonology, Novosibirsk State Medical University, Novosibirsk, Russia; ftizio12@ngs.ru; https://orcid.org/0000-0001-5494-446X
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