Post-COVID syndrome. Pathogenesis and clinical manifestations (Part 1)


DOI: https://dx.doi.org/10.18565/epidem.2022.12.2.60-4

Omarova Kh.G., Makashova V.V., Ponezheva Zh.B., Ageikin A.V., Mitenkova D.M., Ploskireva A.A.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
The paper reviews the results of foreign and Russian investigations of the clinical and pathogenetic features of long-term and post-COVID syndrome in in- and outpatients with COVID-19.

Literature


1. https://yandex.ru/covid19/stat?win=536


2. Li X., Ma X. Acute respiratory failure in COVID-19: is it «typical» ARDS. Crit. Care 2020; 24(1): 198. DOI: 10.1186/s13054-020-02911-9.


3. COVID-19 rapid guideline: managing the long-term effects of COVID-19 NICE guideline [NG188. Published date:18 December 2020]. NICE


4. WHO European Regional Technical Briefing. Rehabilitation after COVID-19: what we know and what resources we have. Virtual meeting organized by the WHO Regional Office for Europe. Copenhagen: WHO Regional Office for Europe; 2022. License: CC BY-NCSA 3.0 IGO. https://apps.who.int/iris/bitstream/handle/10665/351043/WHO-EURO-2022-3995-43754-62897-rus.pdf?sequence=1&isAllowed=y


5. Benjamin Davido, Sophie Seang, Roland Tubiana, Pierre de Truchis. Post-COVID-19 chronic symptoms: a postinfectious entity? Clin. Microbiol, Infect. 2020 Nov;26(11):1448-1449. doi: 0.1016/j.cmi.2020.07.028


6. Рекомендации по ведению больных с коронавирусной инфекцией COVID-19 в острой фазе и при постковидном синдроме в амбулаторных условиях. https://guidelines.mgnot.ru/v2_2021


[Recommendations for the management of patients with COVID-19 coronavirus infection in the acute phase and with sand-like syndrome on an outpatient basis]. (In Russ,), https://guidelines.mgnot.ru/v2_2021


7. FLCCC Alliance – COVID-19 Management Protocol, 02-22-2022, Version 68. https://covid19criticalcare.com/wp-content/uploads/2020/12/FLCCC-Protocols-E28093-A-Guide-to-the-Management-of-COVID-19.pdf


8. Love S., Chalmers K., Ince P., Esiri M, Attems J., Jellinger K. et al. Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue. Am. J. Neurodegener. Dis. 2014; 3(1): 19–32.


9. Kehoe P.G., Wong S., Mulhim N.A.L., Palmer L.E., Miners J.S. Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-beta and tau pathology. Alzheimers Res. Ther. 2016; 8(1): 50. DOI: 10.1186/s13195-016-0217-7


10. Kuo C.L., Pilling L.C., Atkins J.L., Masoli J.A.H., Delgado J., Kuchel G.A. et al. APOE e4 Genotype Predicts Severe COVID-19 in the UK Biobank Community Cohort. J. Gerontol. A Biol. Sci. Med. Sci. 2020; 75(11): 2231–2. DOI: 10.1093/gerona/glaa131


11. Futtrup J., Margolinsky R., Benros M.E., Moos T., Routhe L.J., Rungby J. et al. Blood-brain barrier pathology in patients with severe mental disorders: a systematic review and meta-analysis of biomarkers in casecontrol studies. Brain Behav Immun. Health 2020; 90: 364–80. DOI: 10.1016/j.bbi.2020.08.028


12. Miners S., Kehoe P.G., Love S. Cognitive impact of COVID-19: looking beyond the short term. Alzheimer’s Res. Ther. 2020; 12(1): 170. DOI: 10.1186/s13195-020-00744-w


13. Naughton S.X., Raval U., Pasinetti G.M. Potential Novel Role of COVID-19 in Alzheimer’s disease and preventative mitigation strategies. J. Alzheimers Dis. 2020; 76(1): 21–5. DOI: 10.3233/JAD-200537


14. Pinna P., Grewal P., Hall J.P., Tavarez T., Dafer R.M., Carg R. et al. Neurological manifestations and COVID-19: experiences from a tertiary care center at the frontline. J. Neurol .Sci. 2020; 415: 116969. DOI: 10.1016/j.jns.2020.116969


15. Magoon R. Pulmonary vasculature in COVID-19: mechanism to monitoring! Korean. J. Anesthesiol. 2021; 74(2): 186–7. DOI: 10.4097/kja.20536


16. Carfi A., Bernabei R., Landi F. Gemelli Against COVID-19 Post-Acute Care Study Group Persistent Symptoms in Patients after Acute COVID-19. JAMA 2020; 324(6): 603–5. DOI: 10.1001/jama.2020.12603


17. Tenforde M.W., Kim S.S., Lindsell C.J., Rose E.B., Shapiro N.I., Files D.C. et al. Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network – United States, March–June 2020. MMWR Morb Mortal Wkly Rep. 2020; 69(30): 993–8. DOI: 10.15585/mmwr.mm6930e1


18. Van den Borst B., Peters J.B., Brink M., Schoon Y., Bleeker-Rovers C.P., Schers H. et al. Comprehensive Health Assessment 3 Months After Recovery From Acute Coronavirus Disease 2019 (COVID-19). Clin. Infect. Dis. 2021; 73(5): e1089–98. DOI: 10.1093/cid/ciaa1750


19. Хасанова Д.Р., Житкова Ю.В., Васкаева Г.Р. Постковидный синдром: обзор знаний о патогенезе, нейропсихиатрических проявлениях и перспективах лечения. Неврология, нейропсихиатрия, психосоматика 2021; 13(3): 93–8. DOI: 10.14412/2074-2711- 2021-3-93-98


Khasanova D.R., Zhitkova Yu.V., Vaskayeva G.R. [Kidney syndrome: a review of knowledge about pathogenesis, neuropsychiatric manifestations and treatment prospects]. Neurology, neuropsychiatry, psychosomatics 2021; 13(3): 93–8. (In Russ.). DOI: 10.14412/2074-2711- 2021-3-93-98


20. Venkatesan P. NICE guideline on long COVID. Lancet Respir. Med. 2021; 9(2): 129. DOI: 10.1016/S2213-2600(21)00031-X


About the Autors


Khadizhat G. Omarova, Head, Clinical Research Department, Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Well-Being, Moscow, Russia; omarova71@inbox.ru; https://orcid.org/0000-0002-9682-2230
Professor Vera V. Makashova, MD, Leading Researcher, Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Well-Being, Moscow, Russia; veramakashova@yandex.ru; https://orcid.org/0000-0002-0982-3527
Zhanna B. Ponezheva, MD, Head, Clinical Department of Infectious Pathology, Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Well-Being, Moscow, Russia; doktorim@mail.ru; https://orcid.org/0000-0002-6539-4878
Aleхеy V. Ageykin, Junior Researcher, Clinical Department of Infectious Pathology, Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Well-Being, Moscow, Russia; AgeykinAV@yandex.ru; https://orcid.org/0000-0001-5092-4744
Darya M. Mitenkova, Resident, Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Well-Being, Moscow, Russia; mitenkova.dasha@yandex.ru
Professor Antonina A. Ploskireva, MD, Deputy Director for Clinical Services, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Professor, Department of Pediatrics with Childhood Infectious Diseases, Faculty for Professional Education, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia; antonina@ploskireva.com; Scopus: 56848285800; https://orcid.org/ 0000-0002-3612-1889


Similar Articles


Бионика Медиа