Possibilities of biological and mathematical modeling of infection caused by Epstein–Barr virus


DOI: https://dx.doi.org/10.18565/epidem.2020.10.1.93-7

Permyakova A.V., Sazhin A.V., Melekhina E.V., Gorelov A.V.

1) Academician E.A. Vagner Perm State Medical University, Ministry of Health of Russia, Perm, Russia; 2) OOO «LOR Plus» Medical Center, Perm, Russia; 3) Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
The review presents the existing biological and mathematical models of the infectious disease process caused by Epstein–Barr virus (EBV). The existence of EBV in the host can be presented by a cycle consisting of 6 consecutive stages, each of which has its own independent variant of immune regulation. The phenomenon of virus shedding into the biological fluids, into the saliva in particular, which has been modeled with differential equations, is described. The mathematical modeling makes it possible to supplement the existing knowledge about the pathogenesis of the infectious disease process caused by Epstein–Barr virus, as well as to determine the threshold levels of virus shedding into the nonsterile environments for the diagnosis of active infections.
Keywords: Epstein-Barr virus, mathematical model, pathogenesis
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About the Autors

Anna V. Permyakova, Cand. Med. Sci., Associate Professor, Department of Pediatric Infectious Diseases, Academician E.A.Vagner Perm State Medical University, Ministry of Health of Russia, Perm, Russia; e-mail: derucheva@mail.ru; ORCID: http://orcid.org/0000-0001-5189-0347.
Aleksandr V. Sazhin, Otorhinolaryngologist, Director, OOO «LOR Plus» Medical Center, Perm, Russia; e-mail: info@lor-plus.ru; ORCID: http://orcid.org/0000-0001-9069-7304.
Еlena V. Melekhina, Cand. Med. Sci., Associate Professor of Pediatrics, Senior Researcher, Clinical Department of Infectious Diseases, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: e.melekhina@mail.ru; ORCID: http://orcid.org/ 0000-0002-9238-9302
Prof. Aleksandr V. Gorelov, MD, Corresponding Member of the Russian Academy of Sciences; Deputy Director for Research, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: agorelov_05@mail.ru; ORCID: http://orcid.org/0000-0001-9257-0171


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