Русский
Detection rate for sexually transmitted infections by screening for three anatomic loci in at-risk patients
DOI: https://dx.doi.org/10.18565/epidem.2021.11.4.73-9
Popova A.A., Pokrovskaya A.V., Shedko E.D., Gromova A.V., Skachkova T.S., Goloveshkina E.N., Barsky K.A., Kalinin A.A., Pchelin I.V.
1) Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 2) Peoples’ Friendship University of Russia, Moscow, Russia; 3) «Shagi» (Steps) Regional Charitable Public AIDS Control Foundation, Moscow, Russia
Subjects and methods. The investigation enrolled 202 at-risk representatives who lived in Moscow and the Moscow Region. Real-time PCR was used to determine the causative agents of sexually transmitted infections (STIs) in the biomaterial of females (scrape/swab from the cervical canal, oropharynx, and anus) and males (primary urine sample, scrape/swab from the oropharynx and anus).
Results. The out-of-hospital examination showed that the incidence of STIs in at-risk patients was 43.6%. The highest prevalence of STIs was observed in the HIV-infected and non-HIV infected MSM (HIV/MSM and non-HIV/MSM) (54 and 44%, respectively) and the less frequent prevalence was seen in female SWs (29.2%). Regardless of the anatomical locus, the detected STI pathogens included C. trachomatis (19.3%), N. gonorrhoeae (14.9%), M. genitalium (13.9%), T. pallidum (4%), and T. vaginalis (1%). Extragenital (rectal and/or oropharyngeal) STIs were more common (70%); genital STIs were noted in 7.1%; genital concurrent with extragenital STIs were recorded in 22.9%. Extragenital STIs were more often detected among HIV/MSM (79.4%) and non-HIV/MSM (75.0%). The SW group exhibited a concurrence of genital and extragenital STIs more frequently (50%).
Conclusion. The high prevalence of STIs in at-risk patients necessitates the introduction of new algorithms for their examination, in particular, biomaterial collection from three anatomical loci for PCR.
Literature
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About the Autors
Anna A. Popova, Cand. Med. Sci., Senior Researcher, Department of Specialized Research Laboratory for AIDS Epidemiology and Prevention, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Moscow, Russia; asya-med@mail.ru; https://orcid.org/0000-0001-9484-5917
Anastasia V. Pokrovskaya, Cand. Med. Sci., Senior Researcher, Department of Specialized Research Laboratory for AIDS Epidemiology and Prevention, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Moscow, Russia;; Associate Professor, Department of Infectious Diseases with Courses of Epidemiology and Phthisiology, Peoples’ Friendship University of Russia, Moscow, Russia; pokrovskaya_av@mail.ru; http://orcid.org/0000-0002-2677-0404
Elizaveta D. Shedko, Junior Researcher, Laboratory for Molecular Diagnosis and Epidemiology of Reproductive Tract Infections, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Moscow, Russia; shedko@cmd.su; https://orcid.org/0000-0003-4556-7513
Anastasia V. Gromova, Cand. Biol. Sci., Researcher, Laboratory for Molecular Diagnosis and Epidemiology of Reproductive Tract Infections, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Moscow, Russia; gromova@cmd.su; https://orcid.org/0000-0003-4664-3178
Tatyana S. Skachkova, Researcher, Laboratory for Molecular Diagnosis and Epidemiology of Reproductive Tract Infections, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Moscow, Russia; skachkova@inbox.ru; https://orcid.org/0000-0003-1924-6521
Elena N. Goloveshkina, Cand. Biol. Sci., Head, Laboratory for Molecular Diagnosis and Epidemiology of Reproductive Tract Infections, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Moscow, Russia; goloveshkina@cmd.su; https://orcid.org/0000-0002-0536-2874
Kirill A. Barskiy, Master of Public Health; Program Manager; «Shagi» Regional Charitable Public AIDS Control Foundation, Moscow, Russia; hivpress@gmail.com
Alexander A. Kalinin, Social Worker; «Shagi» Regional Charitable Public AIDS Control Foundation Moscow, Russia; kalinin.aleksandr.an@gmail.com
Igor V. Pchelin, Chairman of the Board, «Shagi» Regional Charitable Public AIDS Control Foundation, Moscow, Russia; shagi@hiv-aids.ru
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