The course of influenza and its complications in the conditions of one hospital


DOI: https://dx.doi.org/10.18565/epidem.2021.11.1.84-9

Sapronov G.V., Dyachenko V.V., Shevchenko N.G., Glago­leva N.M., Trushakova S.V., Krasnoslobodtsev K.G., Nikolaeva L.I., Burtseva E.I.

1) Central Clinical Hospital with Polyclinic, Presidential Administration of the Russian Federation, Moscow, Russia; 2) Honored Academician N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health, Moscow, Russia
Objective. To analyze moderate and severe influenza cases in the clinical center in the 2018–2019 season and to generalize clinical manifestations, complications, and follow-up cases.
Subjects and methods. The retrospective study enrolled 61 patients aged 18–95 years with a confirmed diagnosis of influenza. Influenza virus RNA was detected by a reverse transcription-polymerase chain reaction (PCR) assay. IFNL3 single nucleotide polymorphism (rs8099917 T/G) and IFNL4 (rs12979860 C/T) were determined by PCR using the certified Russian reagent kit.
Results. The predominant influenza A (H1N1)pdm09 strain was detected in 97% of patients with typical clinical signs of the disease. The proportion of vaccinated patients was 9.8%. The main complication of influenza was community-acquired pneumonia (54%). The combination of the antiviral drugs oseltamivir and imidazolylidene pentandiol acid (IPA) did not increase the efficiency of treatment. Complaints persisted in a significant proportion of patients within 30 days following hospital discharge. There was a tendency towards more frequent detection of the IFNL4 rs12979860 TT genotype in patients with pneumonia.
Conclusion. The disease had typical clinical presentations, with community-acquired pneumonia prevailing among the complications. No complications of influenza occurred in patients under 30 years of age and in vaccinated patients. Most patients had a long recovery period.
Keywords: IFN-λ3, influenza virus, influenza, genetic polymorphism, complications, follow-up
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About the Autors

Georgy V. Sapronov, Can. Med. Sci., Head, Infectious Diseases Unit Two, Central Clinical Hospital with Polyclinic, Presidential Administration of the Russian Federation, Moscow, Russia; g_sapronov@mail.ru; http://orcid.org/0000-0002-2154-2904
Veronika V. Dyachenko, Infectiologist, Central Clinical Hospital with Polyclinic, Presidential Administration of the Russian Federation, Moscow, Russia; doctorvv@bk.ru; http://orcid.org/0000-0003-3258-8657
Nadezhda G. Shevchenko, Infectiologist, Central Clinical Hospital with Polyclinic, Presidential Administration of the Russian Federation, Moscow, Russia; dr.nadya@inbox.ru; ORCID: http://orcid.org/0000-0002-2486-4554
Natalia M. Glagoleva, Can. Med. Sci., Head, Infectious Diseases Unit One, Central Clinical Hospital with Polyclinic, Presidential Administration of the Russian Federation, Moscow, Russia; nglagoleva5@gmail.com; http://orcid.org/0000-0001-5721-4593
Svetlana V. Trushakova, Can. Biol. Sci., Senior Researcher, Laboratory of Influenza Etiology and Epidemiology, Honored Academician N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health, Moscow, Russia; s.trushakova@gmail.com; http://orcid.org/0000-0002-9610-3041
Kirill G. Krasnoslobodtsev, Researcher, Laboratory of Influenza Etiology and Epidemiology, Honored Academician N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health, Moscow, Russia; kkg_87@mail.ru; http://orcid.org/0000-0003-1745-9128
Lyudmila I. Nikolaeva, Biol.D, Head, Laboratory of Biological Agents, Honored Academician N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health, Moscow, Russia; L.i.nikolaeva@mail.ru; http://orcid.org/0000-0002-1323-5568
Elena I. Burtseva, MD, Head, Laboratory of Biological Agents, Honored Academician N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health, Moscow, Russia; elena-burtseva@yandex.ru; https://orcid.org/0000-0003-2518-6801


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