The results of influenza immunoprophylaxis in the 2015–2016 epidemic season


Selkova E.P., Aleshkin V.A., Grenkova T.A., Katlinsky A.V., Polezhaeva N.A., Suranova T.G., Lapickaya A.S.

1G.N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare; 2«Protection» All-Russian Center for Disaster Medicine, Ministry of Health of Russia, Moscow
The analysis of the incidence of influenza in the Russian Federation over the last 20 years have shown that influenza immunization leads to substantially reduced morbidity rates, the prevention of complications, and lower death rates. The paper gives the results of monitoring the epidemiological situation of influenza in the 2015–2016 epidemic season and analyzes the efficiency of immunization with Russian vaccines against influenza in the population of the Russian Federation within the National Immunization Calendar in the 2015–2016 epidemic season. There was a low incidence rate (2.7% of cases) and the severe course of the disease was absent in the people vaccinated against influenza. Influenza-related deaths were mainly due to delayed care-seeking and concomitant chronic diseases in the victims. The Russian influenza vaccines «Grippol®», «Grippol® plus», «Savigripp®», and «Ultrix®» were found to be highly effective and safe.

Literature


1. WHO. Guidelines for Pharmacological Management of Pandemic (H1N1) 2009 Influenza and other Influenza Viruses. Publication date: 20 August 2009.

2. Popova A.Yu., Ezhlova E.B., Melnikova A.A., Frolova N.V., Mikheev V.N., Ryzhikov A.B. [Preliminary results of the epidemic season 2015–2016 influenza and acute respiratory viral infections in the Russian Federation]. Соnsilium Мedicum 2016; 18(3): 8–11. (In Russ.).

3. [≪On additional measures for the prevention of influenza and acute respiratory viral infections≫. (Rospotrebnadzor letter № 01/9343-13-32 from 16.08.2013)]. http://72.rospotrebnadzor.ru/content/548/29744/ (In Russ.).

4. [State program of the Russian Federation ≪Development of Нealth≫. Approved by the Decree of Government of Russian Federation № 2511-p dated 24.12.2012]. http://www.rosminzdrav.ru /ministry/programms/health/info (In Russ.).

5. Center for Disease Control and Prevention/ People at High Risk of Developing Flu-Related Complications. 2016. http://www.cdc.gov/flu/about/disease/high_risk.htm.

6. [Sanitary and epidemiological regulations SP 3.1.2.3117-13 ≪Prevention of influenza and other acute respiratory viral infections ≫]. http://rospotrebnadzor.ru/documents/details.php?ELEMENT_ID=1770 (In Russ.).

7. [State report ≪On the state sanitary and epidemiological wellbeing of the population in the Russian Federation in 2015≫]. http://rospotrebnadzor.ru/documents/ details.php?ELEMENT_ID=6851 (In Russ.).

8. Romanenko V.V., Briko N.I., Saltykov T.S., Ankudinova A.V., Semenova L.V., Klyachinа A.S. [Influence of mass immunization in the epidemic process of influenza and acute respiratory viral infections (for example, the Sverdlovsk region)]. Epidemiologiya i vakcinoprofilaktika 2016; 1(86): 56–60. (In Russ.).

9. Popova A.Y., Ezhlova E.B., Melnikova A.A., Frolova N.V.. Mikheev V.N.. Ryzhikov A.B., Ilicheva T.N., Domkino A.M., Mikheeva I.V., Saltykov T.S. [Influence of the annual immunization against influenza on the incidence of this infection of the Russian Federation]. Epidemiologiya i vakcinoprofilaktika 2016; 1(86): 48–55. (In Russ.).

10. [≪On the outcome of the epidemic season of influenza and SARS 2015–016.≫. (Rospotrebnadzor letter № 01/778316-27 from 20.06.2016)]. http://docs.cntd.ru/document/456027388 (In Russ.).

11. Selkova E.P., Grenkova T.A., Aleshkin V.A., Hoods N.V., Lytkina I.V., Mikhailova E.V., Yashin A.Y., Fedyakina I.T. [The study of the immunogenicity, efficacy and tolerability ≪Ultriks≫ domestic vaccine among high-risk individuals, and the incidence of infection with influenza and acute respiratory viral infections]. Èpidemiologiȃ i infectionnye bolezni. Aktual’nye voprosy 2016; (1): 59–6. (In Russ.).

12. Osterholm M.T., Kalley N.S., Sommer A., Belongia E.A., Efficacy and effectiveness of influenza vaccines:a systematic review and metaanalysis. Lancet Infect. Dis. 2012; (12); 36–4.

13. Briko N.I. [Vaccination – the decisive measure reducing the burden of infectious diseases among adults]. Èpidemiologiȃ i infectionnye bolezni. Aktual’nye voprosy 2013; (4): 10–1. (In Russ.).

14. [The order of Ministry of health of Russia №. 755Н from 27.10.2015 ≪On approval of statistical report № 1-flu ≪Information on acute respiratory viral infections, including the flu≫ and the procedure for its completion≫]. http://docs.cntd.ru/document/420314842 (In Russ.).

15.Semenov B.F. [The concept of delayed death in influenza vaccination and tactics heart attacks, strokes and deaths during this infection]. Russkij medicinskij zhurnal 2003; 11(22): 1266–1271. (In Russ.).

16. [Resolution of 03.06.2016 № 70 ≪On measures for the prevention of influenza and acute respiratory viral infections in the epidemiological season 2016–2017≫]. http://rospotrebnadzor.ru /deyatelnost/epidemiological-surveillance/?ELEMENT_ID=6687 (In Russ.).

17. Center for Disease Control and Prevention. CDC. Estimates of deats associated with seonsal influenza-United States, 1976–2007. MMWR Morb. Mortal Wkly Rep. 2010; 59: 1057–62.

18. Simonson L. The global impact of influenza and mortality. Vaccine 1999; 23(suppl): 3–10.

19. [Health care in Russia. 2015. The statistical compilation]. Moscow: Rosstat, 2015. 174 p. (In Russ.).

20. Michol K.L., Nordin J., Mullooy J., Lask R., Fillbrandt K., Iwane M. Influenza vaccinacion and reduction in hospitalizations for cardioac disease and strok amongthe eldery. N. Engl. J. Med. 2003; 348(14): 1322–32.

21. Vaccines against influenza. WHO position paper. Weekly epidemiological record № 47. 23 November 2012: 461–76. htpp//www.who.int/wer

22. Abbas A.K., Lichtman A.H., Pillai S. Cellular and Molekular Immunology. 6 th ed. Philadelphia, PA: Saunders Elsevier, 2007; 215–41.

23. ECDC scientific advice on seasonal influenza vaccination of children and pregnant women: ECDC Technical report / European Centre for Disease Prevention and Control. Stockholm: ECDC, 2012; 68.

24. Centers for Disease Control and Prevention (CDC). Deaths and hospitalizations related to 2009 pandemic influenza A (H1N1). Greece, May 2009 – February 2010. MMWR Mord. Mortal Wkly Rep. 2010; 59(22): 682–6.

25. Nguyen-Van-Tam J.S., Openshaw P.J.M., Hashim A., Gadd E.M., Lim W.S., Semple M.G., Read R.C., Taylor B.L., Brett S.J., McMenamin J., Enstone J.E., Armstrong C., Nicholson K.G. Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May–September 2009). Thorax 2010; 65 (7): 645–51. DOI:10.1136/thx.2010.135210.PMID:20627925.

26. Trubnikova L.I. [Pandemic as a challenge: the lessons of pandemic influenza A/H1N1/ 2009–2010]. StatusPraesens 2011; (7): 37–41. (In Russ.).

27. Mosby L.G., Rasmussen S.A., Jamieson D.J. 2009 pandemic influenza A (H1N1) in pregnancy: a systematic review of the literature. Am. J. Obstet. Gynecol. 2011; 10–8.

28. Louie J., Acosta M., Jamieson D., Honein M.A. Sever 2009 А/H1N1/ influenza in pregnant and postpartum women in California. N. Eng. J. Med. 2010; 362(1): 27–35.

29. World Health Organization. CDC protocol of realtime RTPCR for influenza А/H1N1. http://www.who.int/csr/resources/publications/swineflu/ realtimeptpcr/en/

30. Belokrinitskaya T., Tarbaeva D., Trubitsyna A. [Severe influenza in pregnant women: risk factors, clinical features, prevention]. Vrach 2013; (2): 32–6. (In Russ.).

31. Zhukov D.A. Pharmacoeconomic evaluation of influenza and pneumococcal vaccination in employees of the joint stock company ≪Russian Railways≫ (JSCO ≪RZD≫) on investment for the employer. PHARMACOECONOMICS. Modern pharmacoeconomics and pharmacoepidemiology 2015; 8(4): 40–8. (In Russ.). DOI:10.17749/2070-4909.2015.8.4.040-048

32. Shestakova I.V. [Influenza and SARS: modern aspects of the problem]. Epidemiologiya i infekcii 2016; (1): 6–9. (In Russ.).

33. [The State report on the state sanitary and epidemiological welfare of the population of Russia in 2014]. Moscow: Rospotrebnadzor, 2015. http://www.rospotrebnadzor.ru/documents/details.php?ELEMENT_ID=3692 (In Russ.).


About the Autors


For correspondence: Tatyana A. Grenkova, g4209761@bk.ru


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