Русский
A relationship between antibiotic resistance and biological properties of Enterococcus faecalis isolated from children with urinary tract infection
DOI: https://dx.doi.org/10.18565/epidem.2018.4.39-44
Zaitseva E.A., Melnikova E.A., Komenkova T.S., Luchaninova V.N., Turyansky A.I.
1 Pacific State Medical University, Ministry of Health of Russia, Vladivostok, Russia; 2 Territorial Children’s Clinical Hospital One, Vladivostok, Russia; 3 I.I. Mechnikov North-Western State Medial University, Ministry of Health of Russia, Saint Petersburg, Russia; 4 Primorye Territorial Clinical Hospital One, Vladivostok, Russia
Materials and methods. E. faecalis cultures (n = 71) isolated from the urine samples of children with urinary tract infection were investigated during the study. The biological properties of enterococci were studied by classical microbiological techniques. The sensitivity of enterococci to antimicrobial agents was determined by the disc-diffusion method. The findings were statistically processed using the applied Statistica 10.0 software package.
Results. The majority of the enterococcal cultures tested had polyantibiotic resistance. A relationship was established between the sensitivity of E. faecalis to antimicrobial agents and its biological properties. Uropathogenic enterococci that had proteolytic activity were resistant to many antibacterial drugs with different mechanisms of action. E. faecalis resistant to linezolid and chloramphenicol had a great pathogenic potential (gelatinase, lecithinase and lipolytic activities).
Conclusions. E. faecalis isolated from the urine of children with urinary tract infection have polyantibiotic resistance and certain phenotypic manifestations of biological properties. The set of biological properties of E. faecalis, which has been established in the investigation, can serve as an in vitro diagnostic marker for its resistance to certain groups of antibacterial drugs.
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About the Autors
Elena A. Zaitseva, МD, МD, Associate Professor, Leading Researcher, Central Research Laboratory, Pacific State Medical University, Ministry of Health of Russia, Vladivostok, Russia;
е-mail: elza200707@mail.ru; ORCID: http://orcid.org/0000-0002-2625-8275
Elena A. Melnikova, Head, Regional Children’s Uronephrology Center, Territorial Children’s Clinical Hospital One; Assistant Lecturer, Department of Nursing and Social Work, Pacific State Medical University, Ministry of Health of Russia, Vladivostok, Russia; e-mail: melnikova.uro@ yandex.ru; ORCID: http://orcid.org/0000-0002-4253-2182
Tatiana S. Komenkova, Postgraduate Student, Pacific State Medical University, Ministry of Health of Russia, Vladivostok, Russia; e-mail: atstl@mail.ru; ORCID: http://orcid.org/0000-0001-5841-0369
Valentina N. Luchaninova, MD, Professor, I.I. Mechnikov North-Western State Medical University, Saint-Petersburg; e-mail: lvaln@mail.ru; ORCID: http://orcid.org/0000-0003-1910-6510
Anatoly I. Turyansky, Postgraduate Student, Pacific State Medical University, Ministry of Health of Russia; Urologist, Primorye Territorial Clinical Hospital One, Vladivostok Russia; e-mail: vlanatolii1@mail.ru; ORCID: http://orcid.org/0000-0003-2303-613X
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