Nosocomial pneumonia in a multidisciplinary hospital: results of a retrospective study


DOI: https://dx.doi.org/10.18565/epidem.2018.3.28-34

Chukina M.A., Lukina M.V., Tsarev I.L., Andrushchishina T.B., Morozova T.E.

1 I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia; 2 University Clinical Hospital One, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia
Objective. To assess the incidence, risk factors, and adverse outcome of nosocomial pneumonia (NP) and the prevalence of resistant pathogens.
Subjects and methods. A total of 700 medical histories of patients in the Departments of Surgery and Therapy of the hospital over 2014-2015 were retrospectively analyzed. Clinical factors, the peculiarities of a surgical intervention, the risk of unfavorable outcome, and microbiological results were analyzed. Statistical analysis was carried out using the R 3.3.2 language.
Results. The incidence of NP was 17.1% (n = 120). The adverse outcome was significantly influenced by the presence of cancers (53%; p = 0.003), tracheostomy (60%; p = 6.9e-11), and the duration of mechanical ventilation (p = 4.9e-08). The prognosis was not affected by body mass index (27.0±4.7 versus 26.8 ± 5.7; p = 0.88). There was a preponderance of gram-negative flora: Ac. baumanii Carb+ 15 (31.3%), Klebsiella pneumoniae ESBL 12 (25.0%), Klebsiella pneumoniae Carb+ 6 (12.5%), and Pseudomonas aeruginosa Carb+ 10 (20.8%).
Conclusion. The highest incidence of NP is noted in the departments of cancer and cardiac surgery; the risk factors for adverse outcome are cancers and the duration of mechanical ventilation.
Keywords: resistant gram-negative microorganisms, mechanical ventilation, antibiotic resistance, nosocomial pneumonia
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For citations: Chukina M.A., Lukina M.V., Tsarev I.L., Andrushchishina T.B., Morozova T.E. Nosocomial pneumonia in a multidisciplinary hospital: results of a retrospective study. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2018; (3):28–34


About the Autors

For correspondence:
Maria A. Chukina, Postgraduate Student, Department of Clinical Pharmacology and Internal Diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Address: 6, Bolshaya Pirogovskaya St., Build 1, Моscow 119435, Russia
E-mail: machukina@gmail.com
ORCID: http://orcid.org/0000-0001-5968-3297
Information about the authors:
Maria V. Lukina, Assistant Lecturer, Department of Clinical Pharmacology and Internal Diseases, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia; е-mail: Mari-luk2010@yandex.ru; ORCID: http://orcid.org/0000-0003-0032-2651
Ivan L. Tsarev, Resident, Department of Clinical Pharmacology and Internal Diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia; е-mail: mudravr@gmail.com; ORCID: http://orcid.org/0000-0001-8381-9019
Tatiana B. Andrushchishina, Cand. Med. Sci., Associate Professor, Department of Clinical Pharmacology and Internal Diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia; е-mail: tbraeva@gmail.com; ORCID: http://orcid.org/0000-0001-7940-4443
Tatiana E. Morozova, MD; Professor, Department of Clinical Pharmacology and Internal Diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia; е-mail: temorozova@gmail.com; ORCID: http://orcid.org/0000-0002-3748-8180


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