Antibiotic therapy for skin and soft tissue infections: a comparative analysis of investigations of the efficacy and safety of a new-generation oxazolidinone class drug


Fokina E.G.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
The review gives data on the clinical efficacy and safety of SIVEXTRO® (tedizolid), a new oxazolidinone-class drug. Tedizolid is highly effective in treating gram-positive skin and soft tissue infections (erysipelas, acute cellulitis, skin abscess, wound infections with a lesion size area of at least 75 cm2) and, according to the 2013 FDA guidelines, are considered as acute bacterial infections of the skin and its structures. The ESTABLISH-1 has compared the efficacy and tolerability of a 6-day cycle of treatment with 200-mg once-per-day dose of tedizolid with a 10-day cycle with 600-mg twice-per-day dose of linezolid. The ESTABLISH-2 study has compared 200-mg once-per-day dose of intravenous/oral tedizolid for 6 days with 600-mg twice-per-day dose of intravenous/oral linezolid for 10 days. The investigation has revealed that the 6-day cycle of treatment with tedizolid is as effective as the 10-day cycle with linezolid and demonstrated the best tolerability.
Keywords: tedizolid, wound infections, skin abscess, cellulitis, acute bacterial infections of the skin and its structures, skin and soft tissue infections, staphylococcus, erysipelas, linezolid, streptococcus
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About the Autors

For correspondence:
Elena G. Fokina, Cand. Med. Sci, Infectious Disease Physician, Scientific Advisory Clinical Diagnostic Center, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Address: Address: 3a, Novogireevskaya St., Moscow 111123, Russia
Telephone: +7(495) 788-00-02
E-mail: e-fokina@yandex.ru


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