The natural course of chronic hepatitis C in patients with undifferentiated connective tissue dysplasia


Orlova S.N., Baskhanova M.V.

1 Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia; 2 Repulican Clinical Center of Infectious Diseases, Grozny, Russia
Objective. To evaluate the natural course of chronic hepatitis C (CHC) in patients with undifferentiated connective tissue dysplasia (UCTD).
Subjects and methods. The investigation covered 95 CHC patients who were divided into 2 groups: 1) 63 patients with signs of UCTD; 2) 32 patients without UCTD. Complaints and clinical laboratory parameters were comparatively analyzed in 2011 and 3 years later, in 2014.
Results. After 3 years of the natural course of CHC, Group 1 patients were observed to have pronounced liver functional changes: hepatic tissue disorders and blood biochemical abnormalities, which were accompanied by hemorheologic alterations. In Group 2, the found disorders were unidirectional, but their severity was much less.
Conclusion. The presence of UCTD in CHC patients is important and crucial to the high activity of an inflammatory process and to the rapid development of pronounced hepatic fibrotic processes.
Keywords: natural course, undifferentiated connective tissue dysplasia, chronic hepatitis C
Read entire article

Literature

  1. Onishchenko G.G., Zhebrun A.B. [Viral hepatitis in the Russian Federation. An analytical review]. St. Peterburg: Nauchno-issledovatel’skij institut epidemiologii i mikrobiologii imeni Pastera, 2011. 116 р. (In Russ.).
  2. Pokrovskiy V.I., Zhebrun A.B., (eds.). [Viral hepatitis in the Russian Federation. An analytical review. Vol. 9]. St. Peterburg: Nauchno-issledovatel’skij institut epidemiologii i mikrobiologii imeni Pastera, 2013. 168 р. (In Russ.).
  3. Zaytsev I.A., Kirienko V.T., Shevlyakova N.A., Zhidkikh V.N., Miroshnichenko V.A. [Natural course of hepatitis C]. Suchasna gastroenterologіya 2015; (6); 29–32. (In Ukr.).
  4. Nechaeva G.I., Yakovlev V.M., Konev V.P., Druk I.V., Morozov S.L. [Connective tissue dysplasia: major clinical syndromes, the wording of the diagnosis, treatment]. Lechashchij vrach 2008; (2): 22–8. (In Russ.).
  5. Chemodanov V.V., Krasnova E.E. [Principles of diagnostics and tactics of supporting children with connective tissue dysplasia]. Vestnik Ivanovskoj meditsinskoj akademii 2015; 20(4): 5–14. (In Russ.).
  6. Kadurina T.I., Gorbunova V.N. [Connective tissue dysplasia]. St. Peterburg: Elbi-SPB Publ., 2009. 704 p. (In Russ.).
  7. Afanasev Yu.A., Yurina N.A. (eds.). [Histology, Cytology and Embryology. Tutorial. 5th ed.]. Moscow: Meditsina, 2002. 744 p. (In Russ.).
  8. Serov V.V., Shekhter A.B. [Connective tissue (functional morphology and General pathology)]. Moscow: Meditsina, 1981. 312 p. (In Russ.).
  9. Yakovlev V.M., Glotov A.V., Nechaeva G.I., Konenkov V.I. [Clinical and immunological analysis of the clinical variants of connective tissue dysplasia]. Ter. Arkhiv 1994; (5): 9–13. (In Russ.).
  10. Kucharz E.J. The Collagens: Biochemistry and Pathophysiology. New York: Spinger-Verlag, 1992. 432 p.
  11. Zemtsovskij E.V., Gorbunova V.N. [General characteristics of hereditary disorders (dysplasias) of the connective tissue]. Bulleten Federalnogo tsentra serdtsa, krovi i endokrinologii imeni V.A. Almazova 2013; (4): 47–55. (In Russ.).
  12. Martínez S.M., Crespo G., Navasa M., Forns X. Noninvasive assessment of liver fibrosis. Hepatology 2011; 53(1): 325–35.
  13. Loeys B.L., Dietz H.C., Braverman A.C. The revised Ghent nosology for the Marfan symdrome. J. Med. Genet. 2010; 47(7): 476–85.
  14. Zemtsovskiу E.V. [The concepts of «systemic involvement of connective tissue» and «engagement of the heart» in light of the revision of the Ghent nosology for the diagnosis of Marfan syndrome]. Rossiyskiу kardiologicheskiy zhurnal 2013; 99(1): 7–13. (In Russ.).
  15. Nechaeva G.I., Viktorova I.A., Druk I.V. [Connective tissue dysplasia: prevalence, phenotypic characteristics, Association with other diseases]. Vrach 2006; (1): 19–23. (In Russ.).
  16. Poynard T., Bedosa P., Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR and DOSVIRC groups. Lancet 1997; 349: 825–32.
  17. Ignatova T.M., Abdullaev S.M. [The role of genetic factors in the development and progression of chronic liver diseases].Klinicheskaya gepatologiya 2007; (3): 3–10. (In Russ.).
  18. Dontsov D.V. [The role of immune hematological disorders in the pathogenesis of chronic hepatitis C (review of literature)]. Sovremennye problemy nauki i obrazovaniya 2012; (1). (In Russ.). https://science-education.ru/ru/article/ view?id=5516.
  19. Lukina Ye.A., Sysoeva Ye.P., Gushchin A.Ye., Pavlov Ch.S., Tsvetaeva N.V., Filatov F.P., Khoroshko N.D., Frank G.A., Ivashkin V.T. [Hepatitis C virus in blood cells and bone marrow in patients with obscure hematological syndromes of the liver. Rossiyskiy zhurnal gastroenterologii, gepatologii, koloproktologii 2000; (1): 23–28. (In Russ.).
  20. Ashirova A.B., Orlova S.N. Clinical-pathogenetic role of the syndrome of connective tissue dysplasia in patients with primary and recurrent erysipelas Meditsinskiy vestnik Yuga Rossii 2012; (1): 29–33. (In Russ.).


About the Autors

For correspondence:
Prof. Svetlana N. Orlova, MD, Head, Department of Infectious Diseases, Epidemiology and Dermatovenereology, Ivanovo State Medical Academy, Ministry of Health of Russia
Address: 8, Sheremetievsky Prospekt, Ivanovo 142290, Russia
Теlephone: +7(4932) 38-43-44
Е-mail: novoselov-vi@rambler.ru
Information about the authors:
Markha V. Baskhanova, Postgraduate Student, Department of Infectious Diseases, Epidemiology and Dermatovenereology, Ivanovo State Medical Academy, Ministry of Health of Russia; Infectious Disease Physician, Republican Clinical Center of Infectious Diseases, Grozny, Russia;
е-mail: marh.74@mail.ru


Similar Articles

Back to Content

Бионика Медиа