The demographic and clinical characteristics of HIV-infected women in routine clinical practice in the Russian Federation: Results of a multicenter cross-sectional non-interventional study


Voronin E.E., Afonina L.Yu., Orlova-Morozova E.A., Plotnikova Yu.K., Radzikhovskaya M.V.

1Republican Children’s Infectious Diseases Hospital, Research and Practical Center for Prevention and Treatment of HIV Infection in Pregnant Women and Children, Ministry of Health of Russia, Ust-Izhora, Saint Petersburg, Russia; 2Moscow Regional Center for Prevention and Control of AIDS and Infectious Diseases, Moscow, Russia; 3Irkutsk Regional Center for Prevention and Control of AIDS and Infectious Diseases, Irkutsk, Russia; 4Regional Center of AIDS Prevention and Control, Chelyabinsk, Russia
Objective. To describe the demographic profile, characteristics of HIV infection, concomitant diseases, and reproductive choice for women living with HIV and receiving standard medical services in the Russian Federation, by taking into account the status of therapy and the presence of pregnancy in a history.
Subjects and methods. A multicenter cross-sectional epidemiological non-interventional study was conducted, which enrolled 1,131 HIV-infected women from 10 clinical centers of the Russian Federation.
Results. There was a high frequency of infection in women receiving injectable narcotic drugs and a wide range of chronic hepatitis C prevalence. The majority of women had a normal menstrual cycle; moreover, more than one third did not use any contraceptive methods. Among the women who had a history of pregnancy, the latter occurred in one half of them after the diagnosis of HIV infection.
Conclusion. The results of this study may be useful in providing medical care for HIV-positive women in the Russian Federation and in preventing the mother-to-child transmission of HIV.

Literature


1. Pokrovsky V.V., Ladnaya N.N., Sokolova E.V., Buravtsova E.V. [HIV infection. Informative bulletin No 38]. Moscow: Federal’nyj nauchno-metodicheskij centr po profilaktike i borb’be so SPIDom, 2013. (In Russ.). http://www.hivrussia. ru/files/bul_38.pdf.

2. Pokrovsky V.V., Ladnaya N.N., Sokolova E.V., Buravtsova E.V. [HIV-infection. Informative bulletin No 35]. Moscow: Federal’nyj nauchno-metodicheskij centr po profilaktike i borb’be so SPIDom, 2011. (In Russ.). http://www.hivrussia. ru/files/bul_35.pdf.

3. Pokrovsky V.V., Ladnaya N.N., Sokolova E.V., Buravtsova E.V. [HIV-infection. Informative bulletin No 36]. Moscow: Federal’nyj nauchno-metodicheskij centr po profilaktike i borb’be so SPIDom, 2012. (In Russ.). http://www.hivrussia. ru/files/bul_36.pdf

4. Ladnaya N.N. [Evolution of epidemic HIV-infection in Russian Federation in 2011. Presentation on the interdepartmental meeting «HIV-infection and addiction: epidemic survey, prevention, adherence of treatment»]. Moscow, 2012. (In Russ.). http://www.hivpolicy.ru/publications/?id = 1268 (In Russ.).

5. World Health Organization. Gender and HIV/AIDS. Geneva: Department of Gender and Women’s Health, WHO, 2003.

6. Johnson M., Samarina A., Xi H. Barriers to access to care reported by women living with HIV across 27 countries. AIDS Care 2015; 27(10): 1220–30.

7. Loutfy M.R., Sherr L., Sonnenberg-Schwan U., Walmsley S.L., Johnson M., d’Arminio Monforte A. Caring for women living with HIV: Gaps in the evidence. Journal of the International AIDS Society 2013; 16: 1850–9.

8. Aziz M., Smith K.Y. Treating women with HIV: is it different than treating men? Current HIV/AIDS Reports 2012; (9): 171–8.

9. Meyer J.P., Zelenev A., Wickersham J.A., Williams C.T., Teixeira P.A., Altice F.L. Gender disparities in HIV treatment outcomes following release from jail: Results from a multicenter study. Am. J.Public Health 2014; 104: 434–41.

10. Robertson K., Bayon C., Molina J.M., McNamara P., Resch C., Muñoz-Moreno J.A., van Wyk J. Screening for neurocognitive impairment, depression, and anxiety in HIV- infected patients in Western Europe and Canada. AIDS Care 2014; 26: 1555–61.

11. [National guidelines on monitoring and treatment of HIV-infected patients. Clinical protocol]. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2015; (6, prilozhenie). (In Russ.).

12. Montes M.L., Pulido F., Barros C. Lipid disorders in antiretroviral-naive patients treated with lopinavir/ritonavir- based HAART: frequency, characterization and risk factors. J. Antimicrob. Chemother. 2005; 55(5): 800–04.

13. Guaraldi G., Stentarelli C., Zona S., Orlando G., Carli F., Ligabue G. Lipodystrophy and anti-retroviral therapy as predictors of sub-clinical atherosclerosis in human immunodeficiency virus infected subjects. Atherosclerosis 2010; 208(1): 222–7.

14. Dzwonek A.B., Novelli V., Schwenk A. Serum leptin concentrations and fat redistribution in HIV-1-infected children on highly active antiretroviral therapy HIV Medicine 2007; 8(7): 433–3807.

15. Nikolaos J.P., Kadoglou P.E., Lampropoulos S. The Pathophysiology of HIV-/HAART-Related Metabolic Syndrome Leading to Cardiovascular Disorders: The Emerging Role of Adipokines. Experimental Diabetes Research Volume 2012, Article ID 103063: 1–7.

16. Hsue P.Y., Hunt P.W., Schnell A., Kalapus S.C., Hoh R., Ganz P., Martin J.N, Deeks S.G. Role of viral replication, antiretroviral therapy, and immunodeficiency in HIV- associated atherosclerosis. AIDS 2009; 23(9): 1059–67.

17. Coll B., Parra S., Alonso-Villaverde C., Aragonés G., Montero M., Camps J., Joven J., Masana L. The role of immunity and inflammation in the progression of atherosclerosis in patients with HIV infection. Stroke 2007; 38(9): 2477–84. http: doi. org/10.1161/STROKEAHA.106.479030

18. Coetzee D., Johnson L. Sexually transmitted infections. In: Karim A.S.S., Karim A.Q., eds. HIV/AIDS in South Africa. Cape Town: Cambridge University Press; 2010: 219–20.

19. World Health Organization. Programmatic and research considerations for hormonal contraception for women at risk of HIV and women living with HIV. 2012.

20. Heikinheimo O., Lähteenmäki P. Contraception and HIV infection in women. Hum. Reprod. Update 2009; 15(2): 165–76.


About the Autors


For correspondence:
Larisa Yu. Afonina, Сand. Med. Sci., Leading Specialist, Republican Children’s Infectious Diseases Hospital, Research and Practical Center for Prevention and Treatment of HIV Infection in Pregnant Women and Children, Ministry of Health of Russia
Address: 3, Shlisselburgskoe Shosse, Ust-Izhora, Saint Petersburg 196645, Russia
Telephone: +7(812) 464-43-40
E-mail: alarissa@ridh.spb.ru
Information about the authors:
Evgeny E. Voronin, MD, Head Doctor, Republican Children’s Hospital of Infectious Diseases, Ministry of Health of Russia, Ust-Izhora, Russia; е-mail: rkibsekretar@yandex.ru
Elena A. Orlova-Morozova, Сand. Med. Sci., Head, Outpatient Department, Moscow Regional Center of AIDS, Moscow, Russia; е-mail: orlovamorozova@gmail.com
Yulia K. Plotnikova, Сand. Med. Sci., Head Doctor, Irkutsk regional Center of AIDS; Irkutsk, Russia; е-mail: plot18@yandex.ru
Margarita V. Radzikhovskaya, Сand. Med. Sci., Head Doctor, Chelyabinsk regional Center of AIDS, Chelyabinsk, Russia; е-mail: rita-rad@mail.ru


Similar Articles


Бионика Медиа