Role of vitamin D in anti-infective immunity


Rudyk A.V.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow
The literature data on the osseous and extraosseous effects of vitamin D, its pleiotropic mechanism of involvement in metabolic processes are analyzed. The paper reviews studies confirming the extraosseous (pleiotropic) effect of vitamin D and describes the pathogenetic ways of realizing the above effects. The anti-inflammatory and immunomodulatory properties of vitamin D as a factor of nonspecific protection in infections of various genesis (viral and bacterial) allow it to be used for the prevention and treatment of tuberculosis, hepatitis C, influenza A, acute respiratory infections, chronic rhinosinusitis, and pneumonia. A relationship of vitamin D to cardiovascular and kidney diseases, immune and nervous system disorders, and aging is considered in terms of the data of current studies. There are data on vitamin D provision in the pediatric population of the Russian Federation and on the normal serum levels of the active vitamin D metabolite 25(OH)D; a stepwise dosage regimen of vitamin D as cholecalciferol for prevention is given. Further studies in this area will be able to reconsider approaches to the therapy of infectious diseases and their prevention from birth to adulthood, by applying the physiological mechanisms of immune regulation.
Keywords: innate immune resistance, pleiotropic effects of vitamin D, children, infection
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About the Autors

For correspondence: Anna V. Rudyk, belka-177@yandex.ru


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