Staphylococcus spp. bacteria in the etiology of purulent-septic infections. New favorites and new directions in disease control


DOI: https://dx.doi.org/10.18565/epidem.2025.15.4.82-88

Borisov A.M., Golubkova A.A., Tutelyan A.V., Ruzhentsova T.A.

1) Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Moscow, Russia; 2) Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 3) Russian Medical Academy of Continuous Professional Education, Moscow, Russia; 4) Moscow Medical University «REAVIZ», Moscow, Russia
Staphylococci are ubiquitous gram-positive microorganisms. Based on their ability to coagulate mammalian blood plasma, Staphylococcus spp. bacteria are divided into two clusters: coagulase-positive staphylococci (CoPS), which include only one species, Staphylococcus aureus, and coagulase-negative staphylococci (CoNS), which are represented by a significant number of species (more than 40). Until recently, pathogenic characteristics were attributed only to S. aureus; however, since the early 1990s, information on nosocomial outbreaks associated with CoNS has become available; their representatives, like S. aureus, have acquired resistance to methicillin (oxacillin). Despite the fact that most Staphylococcus spp. species are symbionts of human biotopes, their pathogenic potential has increased in recent years. Epidemiological monitoring of the circulation of Staphylococcus spp. bacteria in the population, and studying the mechanisms underlying their resistance to environmental factors, including the hospital environment, are necessary to predict the evolution of this type of microorganism and determine its significance in the etiology of nosocomial purulent-septic infections in the modern world.

Literature


1. Божкова С.А., Полякова Е.М., Краснова М.В. Преодоление устойчивости к гентамицину у метициллинорезистентных штаммов стафилококка. Международный журнал прикладных и фундаментальных исследований 2017; 8(часть 1): 97–103.


Bozhkova S.A., Polyakova E.M., Krasnova M.V. (The breaking of resistance to gentamycin in methicillin resistant Staphylococcus aureus strains). International Journal of Applied and Fundamental Research 2017; 8(pt 1): 97–103. (In Russ.).


2. Kim H., Kim E.S., Lee S.C., Yang E., Kim H.S., Sung H. et al. Decreased Incidence of Methicillin-Resistant Staphylococcus aureus Bacteremia in Intensive Care Units: a 10-Year Clinical, Microbiological, and Genotypic Analysis in a Tertiary Hospital. Antimicrob. Agents Chemother. 2020; 64(10): e01082–20. DOI: 10.1128/AAC.01082-20


3. Abdullahi I.N., Lozano C., Ruiz-Ripa L., Fernández-Fernández R., Zarazaga M., Torres C. Ecology and Genetic Lineages of Nasal Staphylococcus aureus and MRSA Carriage in Healthy Persons with or without Animal-Related Occupational Risks of Colonization: A Review of Global Reports. Pathogens 2021; 10(8): 1000–1006. DOI: 10.3390/pathogens10081000


4. Быков А.О., Суворова М.П., Проценко Д.Н., Яковлев С.В., Игнатенко О.В., Бурмистрова Е.Н. и др. Анализ структуры бактериемий и чувствительности к антибиотикам микроорганизмов, выделенных в отделениях реанимации и интенсивной терапии в скоропомощном стационаре в период с 2003 по 2021 г.: ретроспективное наблюдательное исследование. Вестник интенсивной терапии имени А. И. Салтанова 2023; (2): 55–65. DOI: 10.21320/1818-474X-2023-2-55-65


Bykov A.O., Suvorova M.P., Protsenko D.N., Yakovlev S.V., Ignatenko O.V., Burmistrova E.N. et al. (Analysis of the structure of bacteremia and sensitivity to antibiotics of microorganisms isolated in the units of resuscitation and intensive therapy in emergency hospitals from 2003 to 2021: retrospective observational study). Annals of Critical Care 2023; (2): 55–65. (In Russ.). DOI: 10.21320/1818-474X-2023-2-55-65


5. Timsit J.F., Ruppé E., Barbier F., Tabah A., Bassetti M. Bloodstream infections in critically ill patients: an expert statement. Intensive Care Med. 2020; 46(2): 266–284. DOI: 10.1007/s00134-020-05950-6


6. Гостев В.В., Пунченко О.Е., Сидоренко С.В. Современные представления об устойчивости Staphylococcus aureus к бета-лактамным антибиотикам. Клиническая микробиология и антимикробная химиотерапия 2021; 23(4): 375–387. DOI: 10.36488/cmac.2021.4.375-387


Gostev V.V., Punchenko O.E., Siderenko S.V. (Modern understanding of the resistance of Staphylococcus aureus to beta-lactam antibiotics). Clinical Microbiology and Antimicrobial Chemotherapy 2021; 23(4): 375–387. (In Russ.). DOI: 10.36488/cmac.2021.4.375-387


7. Скачкова Т.С., Замятин М.Н., Орлова О.А., Юмцу­нова Н.А., Лашенкова Н.Н., Фомина В.С. и др. Мониторинг метициллинрезистентных штаммов стафилококка в многопрофильном стационаре москвы с помощью молекулярно-биологических методов. Эпидемиология и вакцинопрофилактика 2021; 20(1): 44–50. DOI: 10.31631/2073-3046-2021-20-1-44-50


Skachkova T.S., Zamyatin M.N., Orlova O.A., Yumtsunova N.A., Lashen-kova N.N., Fomina V.S. et al. (Monitoring of methicillin-resistant strains of Staphylococcus in a multidisciplinary hospital in Moscow using molecular biological methods). Epidemiology and Vaccination Prevention 2021; 20(1): 44–50. (In Russ.). DOI: 10.31631/2073-3046-2021-20-1-44-50


8. Frazee B.W., Singh A., Labreche M., Imani P., Ha K., Furszyfer Del Rio J. et al. Methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa community acquired pneumonia: Prevalence and locally derived risk factors in a single hospital system. J. Am. Coll. Emerg. Physicians Open. 2023; 4(6): e13061. DOI: 10.1002/emp2.13061


9. Grice E.A., Segre J.A. The skin microbiome. Nat. Rev. Microbiol. 2011; (9): 244–253. DOI: 10.1038/nrmicro2537


10. Becker K., Heilmann C., Peters G. Coagulase-negative staphylococci. Clin. Microbiol. Rev. 2014; 27: 870–926. DOI: 10.1128/CMR.00109-13


11. Becker K., Both A., Weißelberg S., Heilmann C., Rohde H. Emergence of coagulase-negative staphylococci. Expert Rev. Anti Infect. Ther. 2020; 18: 349–366. DOI: 10.1080/14787210.2020.1730813


12. Heilmann C., Ziebuhr W., Becker K. Are coagulase-negative staphylococci virulent? Clin. Microbiol. Infect. 2019; 25: 1071–1080. DOI: 10.1016/j.cmi.2018.11.012


13. Michels R., Last K., Becker S.L., Papan C. Update on coagulase-negative staphylococci-What the clinician should know. Microorganisms 2021; (9): 830. DOI: 10.3390/microorganisms9040830


14. Bonar E., Międzobrodzki J., Władyka B. The Staphylococcal coagulases. In: Savini V., ed. Pet-to-Man travelling staphylococci. A world in progress. Cambridge: Elsevier, 2018; 95–102. DOI: 10.1016/b978-0-12-813547-1.00007-8


15. Lepidi A. Staphylococcal lipases. In: Savini V., ed. Pet-to-Man travelling staphylococci. A world in progress. Cambridge: Elsevier, 2018; 147–159. DOI: 10.1016/b978-0-12-813547-1.00012-1.


16. Międzobrodzki J., Naidu A.S., Watts J.L., Ciborowski P., Palm K., Wadström T. Effect of milk on fibronectin and collagen type I binding to Staphylococcus aureus and coagulase-negative staphylococci isolated from bovine mastitis. J. Clin. Microbiol. 1989; 27(3): 540–544. DOI: 10.1128/JCM.27.3.540-544.1989


17. Stach N., Kaszycki P., Władyka B., Dubin G. Extracellular proteases of Staphylococcus spp. In: Savini V., ed. Pet-to-Man travelling staphylococci. A world in progress. Cambridge: Elsevier, 2018; 135–145. DOI: 10.1016/b978-0-12-813547-1.00011-x


18. Bukowski M., Władyka B., Dubin A., Dubin G. The Staphylococcal exfoliative toxins. In: Savini V., ed. Pet-to-Man travelling staphylococci. A world in progress. Cambridge: Elsevier, 2018; 127–133. DOI: 10.1016/b978-0-12-813547-1.00010-8


19. Nawrotek P., Karakulska J., Fijałkowski K. The Staphylococcal Panton-Valentine leukocidin (PVL). In: Savini V. ed. Pet-to-Man travelling staphylococci. A world in progress. Cambridge: Elsevier, 2018; 117–125. DOI: 10.1159/000354440


20. Pontieri A. Staphylococcal Lipases. In: Savini V., ed. Pet-to-Man travelling staphylococci. A world in progress. Cambridge: Elsevier, 2018; 147–159. DOI: 10.1016/b978-0-12-813547-1.00008-x


21. Heilmann C., Ziebuhr W., Becker K. Are coagulase-negative staphylococci virulent? Clin. Microbiol. Infect. 2019; 25(9): 1071–1080. DOI: 10.1016/j.cmi.2018.11.012


22. Michalik M., Samet A., Podbielska-Kubera A., Savini V., Międzobrodzki J., Kosecka-Strojek M. Coagulase-negative staphylococci (CoNS) as a significant etiological factor of laryngological infections: a review. Ann. Clin. Microbiol. Antimicrob. 2020; 19(1): 26. DOI: 10.1186/s12941-020-00367-x


23. Foka A., Chini V., Petinaki E., Kolonitsiou F., Anastassiou E.D., Dimitracopoulos G. et al. Clonality of slime-producing methicillin-resistant coagulase-negative staphylococci disseminated in the neonatal intensive care unit of a university hospital. Clin. Microbiol. Infect. 2006; (12): 1230–1233. DOI: 10.1111/j.1469-0691.2006.01565.x


24. Paranthaman K., Wilson A., Verlander N., Rooney G., Macdonald N., Nsonwu O. et al. Trends in coagulase-negative staphylococci (CoNS), England, 2010–2021. Access Microbiol. 2023; 5(6): acmi000491.v3. DOI: 10.1099/acmi.0.000491.v3


25. Ehlersson G., Hellmark B., Svartström O., Stenmark B., Söderquist B. Phenotypic characterisation of coagulase-negative staphylococci isolated from blood cultures in newborn infants, with a special focus on Staphylococcus capitis. Acta Paediatr. 2017; 106: 1576–1582. DOI: 10.1111/apa.13950


26. Nickel N., Brooks S., Mize C., Messina A. Reducing Staphylococcus aureus infections in the neonatal intensive care unit. J. Perinatol. 2022; 42(11): 1540–1545. DOI: 10.1038/s41372-022-01407-4


27. Asadollahi P., Farzan B., Rezaei F., Delfani S., Ashrafi B., Soroush S. First Report on the Characteristics of Methicillin-Resistant Staphylococcus Capitis Isolates and an NRCS-A-clone Related Isolate Obtained from Iranian Children. Infect. Disord. Drug. Targets. 2021; 21(3): 459–463. DOI: 10.2174/1871526520666200511011309


28. Datta M.S., Yelin I., Hochwald O., Kassis I., Borenstein-Levin L., Kugelman A. et. al. Rapid methicillin resistance diversification in Staphylococcus epidermidis colonizing human neonates. Nat. Commun. 2021; 12: 6062. DOI: 10.1038/s41467-021-26392-8


29. Smith J.T., Andam C.P. Extensive horizontal gene transfer within and between species of coagulase-negative Staphylococcus. Genome Biol. Evol. 2021; 13: evab206. DOI: 10.1093/gbe/evab206


30. Ikhimiukor O.O., Souza S.S.R., Marcovici M.M., Nye G.J., Gibson R., Andam C.P. Leaky barriers to gene sharing between locally co-existing coagulase-negative Staphylococcus species. Commun. Biol. 2023; 6(1): 482. DOI: 10.1038/s42003-023-04877-0


31. Arciola C.R., Campoccia D., Montanaro L. Implant infections: adhesion, biofilm formation and immune evasion. Nat. Rev. Microbiol. 2018; 16(7): 397–409. DOI: 10.1038/s41579-018-0019-y


32. França A. The Role of Coagulase-Negative Staphylococci Biofilms on Late-Onset Sepsis: Current Challenges and Emerging Diagnostics and Therapies. Antibiotics (Basel) 2023; 12(3): 554. DOI: 10.3390/antibiotics12030554


33. Gebreyohannes G., Nyerere A., Bii C., Sbhatu D.B. Challenges of Intervention, Treatment, and Antibiotic Resistance of Biofilm-Forming Microorganisms. Heliyon 2019; (5): e02192. DOI: 10.1016/j.heliyon.2019.e02192


34. Плотников Ф.В., Мовсесян Н.А., Лептеева Т.Н., Торосян Т.А., Земко В.Ю., Ильин Е.А. Иммунитет и бактериальные биопленки: современное состояние вопроса (Обзор литературы). Вестник ВГМУ 2021; 20: 7–15. DOI: 10.22263/2312-4156.2021.3.7


Plotnikov F.V., Movsesyan N.A., Leptieva T.N., Torosyan T.A., Zemko V.Y., Ilyin E.A. (Immunity and bacterial biofilms: current state of the issue (Literature review)). Bulletin of Vitebsk State Medical University. 2021; 20: 7–15. (In Russ.). DOI: 10.22263/2312-4156.2021.3.7


35. Rani S.A., Pitts B., Beyenal H., Veluchamy R.A., Lewandowski Z., Davison W.M. et al. Spatial Patterns of DNA Replication, Protein Synthesis, and Oxygen Concentration within Bacterial Biofilms Reveal Diverse Physiological States. J. Bacteriol. 2007; 189: 4223–4233. DOI: 10.1128/JB.00107-07


36. García-Betancur J.C., Lopez D. Cell Heterogeneity in Staphylococcal Communities. J. Mol. Biol. 2019; 431: 4699–4711. DOI: 10.1016/j.jmb.2019.06.011.48


37. Kranjec C., Angeles D.M., Mårli M.T., Fernández L., García P., Kjos M. et al. Staphylococcal Biofilms: Challenges and Novel Therapeutic Perspectives. Antibiotics 2021; (10): 131. DOI: 10.3390/antibiotics10020131


38. França A., Gaio V., Lopes N., Melo L.D.R. Virulence Factors in Coagulase-Negative Staphylococci. Pathogens. 2021; 10(2): 170. DOI: 10.3390/pathogens10020170


39. Berends M.S., Luz C.F., Ott A., Andriesse G.I., Becker K., Glasner C. et al. Trends in Occurrence and Phenotypic Resistance of Coagulase-Negative Staphylococci (CoNS) Found in Human Blood in the Northern Netherlands between 2013 and 2019. Microorganisms 2022; 10(9): 1801. DOI: 10.3390/microorganisms10091801


About the Autors


Aleksandr M. Borisov, Postgraduate Student, G.N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; simba.key@gmail.com; http://orcid.org/0009-0000-2272-0082
Professor Alla A. Golubkova, МD, Leading Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Leading Researcher, Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russia, Moscow, Russia; allagolubkova@yandex.ru; http://orcid.org/0000-0003-4812-2165
Professor Aleksey V. Tutelyan, Academician of the Russian Academy of Sciences, МD, Head, Laboratory of Healthcare-Associated Infections, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; bio-tav@yandex.ru; http://orcid.org/0000-0002-2706-6689
Professor Tatyana A. Ruzhentsova, МD,, Head, Department of Internal Medicine, Moscow Medical University «REAVIZ», Moscow, Russia; ruzhencova@gmail.com; http://orcid.org/0000-0002-6945-2019


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