The immune status of school-age children with an acyclic course of tick-borne encephalitis depending on the premorbid state of the immune system


DOI: https://dx.doi.org/10.18565/epidem.2022.12.2.28-33

Kashuba E.A., Rychkova O.A., Khanipova L.V., Khramova E.B., Lyubimtseva O.A., Ogoshkova N.V., Antonova M.V.

Tyumen State Medical University, Ministry of Health of Russia, Tyumen, Russia
Objective. To study an immune response to changes in the bidirectional (acyclic) course of the meningeal form of tick-borne encephalitis (TBE) in school-age children depending on the presence of clinical signs of immune dysfunction in their histories.
Subjects and methods. Examinations were made in 62 children aged 7–14 years at 1, 2, and 3 weeks of acute TBE. Levels 1 and 2 immunological tests were used.
Results. The acyclic course of the meningeal form of the disease in school-age children has been established to be accompanied by a change in all components of the immune system. Significant deviations relate to the cellular component of immunity and show as prolonged T lymphopenia, an increase in activation markers (HLA-DR, CD50, CD54, CD38, CD71), and no significant decrease in the number of CD4+ and CD8+ lymphocytes. As viewed from the humoral and nonspecific components of immunity, a reduced number of CD20+ lymphocytes, an elevated level of all immunoglobulin classes, and an enhanced neutrophil phagocytic activity with a scarce functional reserve are typical for most children
Conclusion. Children with a history of clinical signs of immune dysfunction as recurrent infection syndrome display a preponderance of activation processes of the cellular and humoral components with a later switch to a secondary immune response.

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About the Autors


Eduard A. Kashuba, MD, Professor, Department of Infectious Diseases, Allergology, and Immunology with Course of Dermatovenereology and Cosmetology, Tumen State Medical University, Ministry of Health of Russia, Tyumen, Russia; kashuba.ed@gmail.com; http://orcid.org/0000-0001-9832-7623
Olga A. Rychkova, MD, Head, Department of Infectious Diseases, Allergology and Immunology with course of dermatology and cosmetology, Tyumen State Medical University, Tyumen, Russia; richkovaoa@mail.ru; http://orcid.org/0000-0002-2566-5370
Elena B. Khramova, MD, Head, Department of Childhood Diseases, Faculty of Pediatrics, Tumen State Medical University, Ministry of Health of Russia, Tyumen, Russia; doctor.khramova@gmail.com; http://orcid.org/0000-0001-8968-3925
Lyudmila V. Khanipova, Cand. Med. Sci., Assistant Professor, Department of Infectious Diseases, Allergology and Immunology with course of dermatology and cosmetology, Tyumen State Medical University, Tyumen, Russia; Ludainf03@yandex.ru; http://orcid.org/0000-0002-8795-4186
Oksana A. Lyubimtseva, Cand. Med. Sci., Assistant Professor, Department of Infectious Diseases, Allergology and Immunology with course of dermatology and cosmetology, Tyumen State Medical University, Tyumen, Russia; loa_1975@mail.ru; http://orcid.org/0000-0002-7360-2657
Natalia V. Ogoshkova, Cand. Med. Sci., Assistant Professor, Department of Infectious Diseases, Allergology and Immunology with course of dermatology and cosmetology, Tyumen State Medical University, Tyumen, Russia; onw13051978@mail.ru; http://orcid.org/0000-0001-6626-2087
Mariya V. Аntonova, Cand. Med. Sci., Assistant Professor, Department of Infectious Diseases, Allergology and Immunology with course of dermatology and cosmetology, Tyumen State Medical University, Tyumen, Russia; antonovamariav@mail.ru; http://orcid.org/0000-0001-7859-1101


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