Features of the clinical course and the COVID-19 epidemic process in the communities of various planning patterns


DOI: https://dx.doi.org/10.18565/epidem.2022.12.1.18-24

Zadoroshnyi A.V., Pshenichnaya N.Yu., Akimkin V.G.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
Objective. To establish a relationship between the clinical and epidemiological course of COVID-19 and the duration of focal morbidity in the communities of various planning patterns.
Materials and methods. In April 15 to June 2, 2020, the investigators carried out a sampling longitudinal prospective analytical study of the course of the clinical and epidemic process in the COVID-19 foci formed in the communities of various planning patterns. There were a total of 515 COVID-19 cases.
Results. A direct relationship was found between the clinical course and features of the COVID-19 epidemic process and the duration of focal morbidity in the communities of various planning patterns. The analyzed epidemiological indicators: cumulative incidence, morbidity, and incidence density significantly increased by the second incubation period (from day 14 to day 28 since the date of registration of the first case of COVID-19 in the community). The increase in these indicators characterizing the course of the infectious process of COVID-19 was accompanied by an intensive rise in new infection cases and by a change in the clinical course of the disease. This was manifested by an increase in the total number of registered community-acquired pneumonias and a decrease in the period of their development. The increase in the intensity of the epidemic process, the change in the clinical course of COVID-19 and the timing of the development of community-acquired pneumonia directly depended on the duration of the focal process of COVID-19. The long current focus was established to have lower epidemiological indicators in the separate community compared to the reported one.
Conclusion. The long current COVID-19 foci formed in the reported and separate communities are characterized by a more intensive epidemic process; the persons who have got infection in the communities have often a severer clinical course.
Keywords: intensity, communities, COVID-19, coronavirus infection, clinical course, duration
Read entire article

Literature

1. Wenjie T., Xiang Z., Xuejun M., Wenling W., Peihua N., Wenbo X. et al. Notes from the Field: A Novel Coronavirus Genome Identified in a Cluster of Pneumonia Cases – Wuhan, China 2019–2020. China CDC Weekly 2020; 2(4): 61–2. http://weekly.chinacdc.cn/en/article/id/a3907201-f64f-4154-a19e-4253b453d10с


2. Kucharski A. J., Russell T. W., Diamond C., Liu Y., Edmunds J., Funk, S. et al. Early dynamics of transmission and control of COVID-19: a mathematical modelling study. Lancet Infect Dis. 2020; 20(5): 553–8. doi: 10.1016/S1473-3099(20)30144-4


3. Kupferschmidt K. The pandemic virus is slowly mutating. But does it matter? Science 2020; 369(6501): 238–9. DOI: 10.1126/science.369.6501.238


4. Bhattacharyya Ch., Das Ch., Ghosh A., Singh A.K., Mukherjee S., Majumder P.P. et al. Global spread of SARS-CoV-2 subtype with spike protein mutation D614G is shaped by human genomic variations that regulate expression of TMPRSS2 and MX1 genes. bioRxiv 2020.05.04.075911. DOI: 10.1101/2020.05.04.075911


5. Краснов Я.М., Попова А.Ю., Сафронов В.А., Федоров А.В., Баданин Д.В. и др. Анализ геномного разнообразия SARS-CoV-2 и эпидемиологических признаков адаптации возбудителя COVID-19 к человеческой популяции (Сообщение 1). Проблемы особо опасных инфекций 2020; (3): 70–82. DOI: 10.21055/0370-1069-2020-3-70-82

Krasnov, Ya. M., Popova, A. Yu., Safronov, V. A., Fedorov, A.V., Badanin, et al. [Analysis of the genomic diversity of SARS-CoV-2 and epidemiological signs of adaptation of the pathogen COVID-19 to the human population (Communication 1)]. Problems of Particularly Dangerous Infections 2020; (3): 70–82. (In Russ.). DOI: 10.21055 / 0370-1069-2020-3-70-82


6. Временные методические рекомендации «Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19)». Версия 11 (07.05.2021). Минздрав России, 2021.https://base.garant.ru/400738625/

[Temporary guidelines «Prevention, diagnosis and treatment of new coronavirus infection (COVID-19)»]. Version 11 (05/07/2021). Ministry of Health of the Russian Federation, 2021. (In Russ.). https://base.garant.ru/400738625/7.


7. Никифоров В.В., Колобухина Л.В., Сметанина С.В., Мазанкова Л.Н., Плавунов Н.Ф., Щелканов М.Ю. и др. Новая коронавирусная инфекция (COVID-19): этиология, эпидемиология, клиника, диагностика, лечение и профилактика. Учебно-методическое пособие. М.: Департамент здравоохранения города Москвы, 2020. 71 с.

Nikiforov V.V., Kolobukhina L.V., Smetanina S.V., Mazankova L.N., Plavunov N.F., Shchelkanov M.Yu.et al. [Novel coronavirus infection (COVID-19): etiology, epidemiology, clinic, diagnosis, treatment and prevention]. Study guide. Moscow: Moscow City Health Department, 2020. 71 p. (In Russ.).


8. Щелканов М.Ю., Колобухина Л.В., Бургасова О.А., Кружкова И.С., Малеев В.В. COVID-19: этиология, клиника, лечение. Инфекция и иммунитет 2020; 10(3): 421–45. doi: 10.15789/2220-7619- CEC-147

Shchelkanov M.Yu., Kolobukhina L.V., Burgasova O.A., Kruzhkova, I.S., Maleev, V.V. [COVID-19: etiology, clinic, treatment–. Infection and immunity 2020; 10(3): 421–45 (In Russ.). doi:10.15789/2220-7619-CEC-147


9. Cao Y., Liu X., Xiong L., Cai K. Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2: a systematic review and meta-analysis. J. Med. Virol. 2020; 92(9): 1449–59. doi: 10.1002/jmv.25822


10. Ганина О.А. Организация быта в университетских общежитиях разного типа. Вестник ПНИПУ. Социально-экономические науки 2018; (4): 82–97. https://cyberleninka.ru/article/n/organizatsiya-byta-v-universitetskih-obschezhitiyah-raznogo-tipa.

Ganina O.A. [Organization of everyday life in university dormitories of different types]. Bulletin of Perm State Technical University. Socio-economic sciences 2018; (4): 82–97. (In Russ.). https://cyberleninka.ru/ article/n/organizatsiya-byta-v-universitetskih-obschezhitiyah-raznogo-tipa


11. Белоцерковская Ю.Г., Романовских А.Г., Смирнов И.П. COVID-19: респираторная инфекция, вызванная новым коронавирусом: новые данные об эпидемиологии, клиническом течении, ведении пациентов. Consilium Medicum 2020; 22(3): 12–20. DOI: 10.26442/20751753.2020. 3.200092

Belotserkovskaya Yu.G., Romanovskikh A.G., Smirnov I.P. [COVID-19: Respiratory Infection Caused by Novel Coronavirus: New Evidence on Epidemiology, Clinical Course, Patient Management]. Consilium Medicum 2020; 22(3): 12–20. (In Russ.). DOI: 10.26442 /20751753.2020.3.200092


12. McAloon, K., Collins,A., Hunt, K., Barber, A., Byrne, A. On., Butler et al. до 6 авторов The incubation period of COVID-19 – A rapid systematic review and meta-analysis of observational research. MedRxiv and bioRxiv 2020. doi: 10.1101/ 2020.04.24.20073957


13. Wang F.S., Zhang C. What to do next to control the 2019-nCoV epidemic? Lancet 2020; 395(10222): 391–3. doi: 10.1016/ S0140-6736(20)30300-7


14. Gorny A.W., Bagdasarian N., Koh A.H., Lim Y.C., Ong J.S., Ng B.S. et al. SARS-CoV-2 in migrant worker dormitories: Geospatial epidemiology supporting outbreak management. Int. J. Infect. Dis. 2021; 103: 389–94. doi.org/10.3390/ijerph18179125


About the Autors

Alexander V. Zadorozhnyi, Resident, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; AlezanderZadoroshnyy@yandex.ru
Professor,Natalia Yu. Pshenichnaya, MD, Deputy Director on Clinical and Analytical Work, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; natalia-pshenichnaya@yandex.ru; https://orcid.org/0000-0003-2570-711X
Professor Vasiliy G. Akimki, MD, Academician of the Russian Academy of Sciences, Director, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; vgakimkin@yandex.ru; http://orcid.org/ 0000-0003-4228-9044


Similar Articles

Back to Content

Бионика Медиа