Anogenital human papillomavirus infection in HIV-infected women (according to the results of a pilot study in the Moscow Region)


DOI: https://dx.doi.org/10.18565/epidem.2021.11.3.40-5

Popova A.A., Domonova E.A., Vinogradova N.A., Shipulina O.Yu.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
Objective. To investigate the prevalence of high-risk human papillomavirus (hrHPV), by simultaneously examining biological materials from the cervical canal and anus of HIV-infected women.
Subjects and methods. The investigation enrolled 101 HIV-infected women living in Moscow and the Moscow Region. Real-time PCR was used to determine hrHPV in a scrape from the cervical canal and anus.
Results. Testing the samples from the cervical canal and anus revealed the high prevalence of hrHPV (60.4%): it was 72.1% and 78.7% the scrapes of epithelial cells in the cervical canal and anus, respectively. At the same time, HPV infection in the cervical canal and anus was recorded in 50.8% of cases; an isolated anal lesion was observed in 27.9% of cases. Simultaneous diagnosis of human papillomavirus infection in the two studied loci indicated that in 67.7% of cases, the anal scrape contained hrHPV genotypes that were absent in the cervical scrape. The ratio of the detected hrHPV genotypes varies substantially with the studied locus. More than one hrHPV genotype was detected in 56.3% of the anal samples, whereas only one genotype was found in 65.9% of the cervical samples.
Conclusion. The high detection rate of hrHPV DNA in the epithelial cells of the cervical canal and anus of HIV-infected women, as well as a broad range of detectable hrHPV genotypes demonstrate the need for the screening for precancerous diseases of the cervix and anus, which is based on HPV testing with the determination of 14 hrHPV genotypes.
Keywords: anal cancer, HPV testing, cervical cancer, human papillomavirus, HIV infection, women
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About the Autors

Anna A. Popova, Cand. Med. Sci., Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance of Consumer Rights Protection and Human Well-Beingsia; asya-med@mail.ru; https://orcid.org/0000-0001-9484-5917
Elvira A. Domonova, Cand. Biol. Sci., Head, Scientific Group for New Methods to Diagnose Opportunistic and Human Papillomavirus Infections, Department of Molecular Diagnosis and Epidemiology, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance of Consumer Rights Protection and Human Well-Being; еlvira.domonova @pcr.ms; http://orcid.org/0000-0001-8262-3938
Nadezhda А. Vinogradova, Junior Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance of Consumer Rights Protection and Human Well-Being; klimova@cmd.su; http://orcid.org/0000-0003-3288-0244
Olga Yu. Shipilina, Cand. Med. Sci., Head, Subdivision for Molecular Diagnostic Methods, Department of Molecular Diagnosis and Epidemiology, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance of Consumer Rights Protection and Human Well-Being; olga.shipulina@pcr.ms; http://orcid.org/0000-0003-4679-6772


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