Rare opportunistic lesions caused by protozoa in patients with HIV infection


DOI: https://dx.doi.org/10.18565/epidem.2020.10.3.123-30

Ermak T.N.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
The paper presents materials on the features of a number of opportunistic diseases that still occur rarely in Russia, which are registered in the country or can be imported from endemic regions. The findings will assist physicians caring for HIV-infected patients in diagnosing and treating difficult cases.

Literature


1. Лейшманиоз. Информационный бюллетень ВОЗ. Сентябрь 2016. Обновлен в марте 2018. http://www.who.int/mediacentre/factsheets/fs375/ru/

[Leishmaniases. Newsletters of the WHO. September 2016. Fact sheet Updated. March 2018]. (In Russ.). http://www.who.int/mediacentre/ factsheets/fs375 ru/


2. Борьба с лейшманиозом. Доклад на заседании Комитета экспертов ВОЗ по борьбе с лейшманиозом. Женева, 22–26 марта 2010 г. Серия технических докладов ВОЗ № 949]. ВОЗ, 2010. 225 с.

[The control of leishmaniasis. Report at the meeting of the WHO Committee of experts on leishmaniasis control. Geneva, 22–26 March, 2010. WHO technical report series № 949. WHO, 2010. 225 р. (In Russ.).


3. Баранец М.С., Ермак Т.Н., Понировский Е.Н. Клинико-эпидемиологические особенности висцерального лейшманиоза в Республике Крым. Тер. архив 2017; (11): 100–4. https://doi.org/10. 17116/terarkh20178911100-104

Baranets M.S., Ermak T.N., Ponirovsky E.N. [Clinical and epidemiological features of visceral leishmaniasis in the Republic of Crimea]. Terapevticheskiy arhiv 2017; (11): 100–4. (In Russ.). https://doi.org/10.17116/terarkh20178911100-104


4. Alvar J., Aparicio P., Aseffa A., Den Boer M., Cañavate C., Dedet J.P. et al. The relationship between leishmaniasis and AIDS: the second 10 years. Clin. Microbiol. Rev. 2008; 21(2): 334–59. DOI: 10.1128/CMR.00061-07


5. Andreani G., Lodge R., Richard D., Tremblay M.J. Mechanisms of interaction between protozoan parasites and HIV. Curr. Opin. HIV AIDS. 2012; 7(3): 276–82. DOI: 10.1097/COH.0b013e32835211e9


6. Garg R., Lodge R., Descoteaux A., Tremblay M.J. Leishmania infantum promastigotes reduce entry of HIV into macrophages through a lipophosphoglycan-mediated disruption of lipid rafts. J. Infect. Dis. 2008; 197(12): 1701–8. DOI: 10.1086/588146


7. Rosenthal E. P., Marty P., del Giudice C., Pradier C., Ceppi J.A., Gastaut Y. et al. HIV and Leishmania coinfection: a review of 91 cases with focus on atypical locations of Leishmania. Clin. Infect. Dis. 2000; 31: 1093–5.


8. Russo R., Laguna F., Lopez-Velez R., Medrano F.J., Rosenthal E., Cacopardo B., Nigro L.. Visceral leishmaniasis in those infected with HIV: clinical aspects and other opportunistic infections. Ann. Trop. Med. Parasitol. 2003; 97(Suppl. 1): 99–105.


9. Cota G.F., de Sousa M.R., Rabello A. Predictors of visceral leishmaniasis relapse in HIV-infected patients: a systematic review. PLoS Negl. Trop. Dis. 2011; 5(6): e1153. DOI: 10.1371/journal.pntd.0001153


10. Pintado V., Martin-Rabadan P., Rivera M. L., Moreno S., Bouza E. Visceral leishmaniasis in human immunodeficiency virus (HIV)-infected and non-HIV-infected patients. A comparative study. Medicine (Baltimore) 2001; 80: 54–73


11. Barat C., Zhao C., Ouellette M., Tremblay M.J. HIV-1 replication is stimulated by sodium stibogluconate, the therapeutic mainstay in the treatment of leishmaniasis. J. Infect. Dis. 2007; 195: 236–45.


12. Lopez-Velez R. The impact of highly active antiretroviral therapy (HAART) on visceral leishmaniasis in Spanish patients who are co-infected with HIV. Ann. Trop. Med. Parasitol. 2003; 97(Suppl. 1): 143–7.


13. Casado J.L., Lopez-Velez R., Pintado V., Quereda C., Antela A., Moreno S. Relapsing visceral leishmaniasis in HIV-infected patients undergoing successful protease inhibitor therapy. Eur. J. Clin. Microbiol. Infect. Dis. 2001; 20: 202–5.


14. Fernandez Cotarelo M.J., Abellan Martinez J., Guerra Vales J.M., Martinez Sanchez P., Gomez M., De La Barcena R., Salto Fernandez E. Effect of highly active antiretroviral therapy on the incidence and clinical manifestations of visceral leishmaniasis in human immunodeficiency virus-infected patients. Clin. Infect. Dis. 2003; 37: 973–7.


15. Ермак Т.Н., Кравченко А.В., Груздев Б.М., Филиппов П.Г.Первый случай висцерального лейшманиоза у больного с ВИЧ-инфекцией в России. Тер. архив 1997; 69(11): 48–50.

Ermak T.N., Kravtchenko A.V., Gruzdev B.M., Philippov P.G. [The first case of visceral leishmaniasis in patient with with HIV infection in Russia]. Terapevticheskiy arhiv 1997; (11): 48–50. (In Russ.).


16. Ермак Т.Н. Лейшманиоз и ВИЧ-инфекция. Эпидемиол. инфекц. болезни. Актуал. вопр. 2015; (1): 48–52.

Ermak T.N. [Leishmaniasis and HIV infection]. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2015; (1): 48–52. (In Russ.).


17. Кабанова В.И., Базюк Е.М., Степанова Е.В., Цинзерлинг В.А., Зырянова Ю.О. Клинический случай висцерального лейшманиоза у пациента с ВИЧ-инфекцией. ВИЧ-инфекция и иммуносупрессии 2015; 7(3): 80–6.

Kabanova V.I., Bazyuk Ye.M., Stepanova Ye.V., Zinserling V.A., Zyrianova Yu.O. [Clinical case of Leishmaniasis in a patient with HIV infection]. VICH-infektsiya i immunosupressii 2015; 7(3): 80–6. (In Russ.).


18. Рубцова Н.В., Ермак Т.Н., Плотникова Ю.К., Коваленкова К.Н., Кошкина Е.В., Белых К.А. Новый случай висцерального лейшманиоза у больного ВИЧ-инфекцией в России. Инфекционные болезни 2018; 16(2): 116–9. DOI: 10.20953/1729-9225-2018-2-116-119

Rubtsova N.V., Ermak T.N., Plotnikova Ju.К., Kovalenkova K.N., E.V.Koshkina, Belykh K.А. [A new case of visceral leishmaniasis in a HIVinfected patient in Russia]. Infekcionnye bolezni 2018; 16(2): 116–9. (In Russ.). DOI: 10.20953/1729-9225-2018-2-116-119


19. Чемич М.Д., Троцька ІО, Кулеш Л.П. Вісцеральний лейшманіоз як СНІД-індикаторне захворювання: труднощі в діагностиці та лікуванні. Інфекційні хвороби 2010; (1): 81–4.

Chemych N.D., Trotska І.О., Kulesh K.P. [Visceral leishmaniasis as AIDS indicator disease:  severities of diagnostic and treatment]. Infekcionnye bolezni 2010; (1): 81–4. (In Ukr.).


20. Обгольц Ю.Н., Самойлова Н.Г., Федь С.С., Кармановская С.А., Ковынев И.Б., Поспелова Т.И. Инфекционная патология в практике врача-гематолога: висцеральный лейшманиоз у ВИЧ-инфицированного пациента. Сибирский научный медицинский журнал 2019; 39(1): 72–6. DOI: 10.15372/SSMJ20190110

Obgolts Yu.N., Samoylova N.G., Fed S.S., Karmanovskaya S.A., Kovynev I.B., Pospelova T.I. [Infectious diseases in hematologist’s practice: visceral leishmaniasis in HIV-infected patient]. Sibirskij nauchnyj medicinskij zhurnal 2019; 39(1): 72–6. (In Russ.). DOI: 10.15372/SSMJ20190110


21. Corso P.S., Kramer M.H., Blair K.A., Addiss D.G., Davis J.P., Haddix A.C. Cost of illness in the 1993 waterborne Cryptosporidium outbreak, Milwaukee, Wisconsin. Emerg. Infect. Dis. 2003; 9(4): 426–31. doi: 10.3201/eid0904. 020417


22. Morgan U.M., Xiaol L., Fayer R., Lal A.A., Thompson R.C. Variation in Cryptosporidium: towards a taxonomic revision of the genus. Int. J. Parasitol. 1999; 29: 1733–51.


23. Маклаклин Дж. Идентификация и типирование криптоспоридий: молекулярно-биологические подходы. Центральная лаборатория общественного здравоохранения. Лондон, Великобритания. «Болезни и возбудители». КМАХ 2000; 2(3): 1–3.

Maklaklin G. [Identification and typing of cryptosporidia: molecular and biological approaches. Central laboratory of public health. London, Great Britain]. «Bolezni i vozbuditeli». CMAC 2000; 2(3): 1–3. (In Russ.).


24. Дехнич А.В. Клинические и микробиологические аспекты криптоспоридиоза. Клиническая микробиология и антимикробная химиотерапия 2000; 2(3): 51–57.

Dehnich A.V. [Clinical and microbiological aspects of Cryptosporidiosis]. Klinicheskaya mikrobiologiya i antimikrobnaya khimioterapiya 2000; (2): 51–7. (In Russ.).


25. Соколова О.И., Демьянов А.В., Дедов В.А., Соколова Ю.Я., Яковлев А.А. Криптоспоридиоз у ВИЧ-инфицированных пациентов: диагностика и клинико-лабораторная характеристика. Журнал инфектологии 2012; 4(2): 26–32.

Sokolova O.I., Demianov A.V., Dedov V.A., Sokolova Yu.Ya., Iakovlev A.A. [Cryptosporidiosis in HIV-patients: diagnostic and clinic laboratory date]. Zhurnal infektologii 2012; 4(2): 26–32. (In Russ.).


26. Cryptosporidiosis Outbreak at a Summer Camp – North Carolina. CDC 2009. 2011; 60(27): 918–22.


27. Dupont H., Chapell C., Sterling C. The infectivity of Cryptosporidium parvum in healthy volonteers. N. Engl. J. Med. 1995; 332: 855–9.


28. Lumadue J.A., Manabe Y.C., Moore R.D., Belitsos P.C., Sears C.L., Clark D.P. A clinicopathologic analysis of AIDS-related cryptosporidiosis. AIDS 1998; 12(18): 2459–66.


29. Chen X.M., Keithly J.S., Paya C.V., La Russo N.F. Cryptosporidiosis. N. Engl. J. Med. 2002; 346(22): 1723–31. doi:10.1056/NEJMra013170


30. Vakil N.B., Schwartz S.M., Buggy B.P., Brummitt C.F., Kherellah M., Letzer D.M. Biliary cryptosporidiosis in HIV-infected people after the waterborne outbreak of cryptosporidiosis in Milwaukee. N. Engl. J. Med. 1996; 334(1): 19–23. doi: 10.1056/NEJM199601043340104.


31. Pozio E., Rivasi F. Cacciò S.M. Infection with Cryptosporidium hominis and reinfection with Cryptosporidium parvum in a transplanted ileum. APMIS 2004; 112: 309–13.


32. Fayer R., Xiao L. Cryptosporidium and Cryptosporidiosis. Second Edition (Boca Raton). New York: CRC Press, 2007. 560 p.


33. Hunter P.R., Nichols G. Epidemiology and clinical features of Cryptosporidium infection in immunocompromised patients. Clin. Microbiol. Rev. 2002; 15(1): 145–54.


34. Mercado R., Buck G.A., Manque P.A., Ozaki L.S. Cryptosporidium hominis infection of the human respiratory tract. Emerg. Infect. Dis. 2007; 13(3): 462–4.


35. Lumadue J.A., Manabe Y.C., Moore R.D., Belitsos P.C., Sears C.L., Clark D.P. A clinicopathologic analysis of AIDS-related cryptosporidiosis. AIDS 1998; 12(18): 2459–66.


36. Mohandas Sehgal R., Sud A., Malla N. Prevalence of intestinal parasitic pathogens in HIV-seropositive individuals in Northern India. Jpn. J. Infect. Dis. 2002; 55: 83.


37. Silva C.V., Ferreira M.S., Borges A.S., Costa-Cruz J.M. Intestinal parasitic infections in HIV/AIDS patients: experience at a teaching hospital in central Brazil. Scand. J. Infect. Dis. 2005; 37(3): 211–5. DOI: 10.1080/ 00365540410020875


38. Покровский В.В., ред. ВИЧ-инфекция и СПИД. Национальное руководство. 2-е изд., перераб. и доп. М.: ГЭОТАР-Медиа; 2020: 165–231.

Pokrovsky V.V. (ed.). [HIV-infection and AIDS. National Guidelines. 2 ed., revised and expanded]. Мoscow: GEOTAR-Media, 2020. 696 p. (In Russ.). 165–231. (In Russ.).


39. Тимофеев С.А. Современные представления о микроспоридиозе человека. Вестн. РАМН. 2015; 70(2): 257–63. https://doi.org/10.15690/vramn. v70i2.1321

Timofeev S.A. [Current Concepts of Human Microsporidiosis]. Vestnik Rossiiskoi Akademii Meditsinskikh Nauk 2015; 70(2): 257–63. (In Russ.) https://doi. org/10.15690/vramn. v70i2.1321.


40. Mildvan D., ed. International Atlas of AIDS. 4th ed. CMG: Springer, 2008: 366


41. Соколова О.И., Демьянов А.В., Боурс Л.С., Дидье Е.С., Скарлатто С.О., Соколова Ю.Я., Яковлев А.А. Микроспоридиоз у ВИЧ-инфицированных пациентов. ВИЧ-инфекция и иммуносупрессии 2011; 3(3): 63–70.

Sokolova O.I., Demianov A.V., Bours L.S., Didje E.S., Scarlatto S.O., Sokolova Yu.Ya., Iakovlev A.A. [Microsporidiosis in HIV-patients]. VICH-infekcia i immunosupressii 2011; 3( 3): 63–70. (In Russ.).


42. Salavert M., Roig P., Nieto A., Navarro V., Borrás R. Enterocolitis caused by Blastocystis hominis and HIV infection. Enferm. Inf. Microbiol. Clin. 1990; 8(1): 63–4.


43. Albrecht H., Stellbrink H.J., Koperski K., Greten H. B. hominis immunodeficiency virus-related diarrhea. Scand. J. Gastroenterol. 1995; 30(9): 909–14.


44. Тихонова Д.В., Федянина Л.В., Плющева Г.Л. Особенности клиники и лабораторных методов диагностики бластоцистоза. Медицинская паразитология и паразитарные болезни 2012; (3):

Tikhonova D.V., Fedyanina L.V., Plusheva G.L. [Features of clinic and laboratory diagnostic methods of blastocystosis]. Meditsinskaya parazitologiya I parazitarnie bolezni 2012; (3): 44. (In Russ.).


45. Токмалаев А.К., Кожевникова Г.М., Половинкина Н.А., Голуб В.П., Барышева И.В. Инфекции Blastocystis spp. в клинической практике. Вестник РУДН 2016; (1): 34–7. Tokmalaev А.К., Kozhevnikova G.М., Polovinkina N.А., Golub V.P., Barisheva I.V. [Blastocystis spp. infections in clinical practice]. Vestnik RUDN 2016; (1): 34–7. (In Russ.).


46. Dubey P., Almeria S. Cystoisospora belli infections in humans: the past 100 years. Parasitology 2019; 146(12): 1490–527. http://dx.doi.org/10.1017/ S0031182019000957


47. Lagrange-Xélot M., Porcher R., Safrati C., de Castro N., Carel O., Magnier J.-D., Delcte V., Molina J.M. Isosporiasis in patients with HIV infection in the highly active antiretroviral therapy era in France. HIV Medicine 2008; 9(2): 126–30.


48. Casillas S.M., Bennett C., Straily A. Notes from the Field: Multiple Cyclosporiasis Outbreaks – United States, 2018. Morbidity and Mortality Weekly Report (MMWR), CDC Weekly 2018; 67(39): 1101–2. https:// www.cdc.gov/parasites/cyclosporiasis/outbreaks/2018/b-071318/ index.html


About the Autors


Tatiana N. Ermak, МD, Leading Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; е-mail: t.ermak@hiv-russia.ru; ORCID: http://orcid.org/ 0000-0001-9490-7129


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