Русский
Prevalence of high-risk human papillomavirus according to the results of anal screening in men stratified by their sexual behavior and HIV status
DOI: https://dx.doi.org/10.18565/epidem.2020.10.3.33-8
Popova A.A., Domonova E.A., Pokrovskaya A.V., Klimova N.A., Shipulina O.Yu., Pokrovsky V.V.
Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
Subjects and methods. Examinations were made in 256 male residents of Moscow and the Moscow Region who had different HIV statuses and sexual behavior. A real-time PCR assay was used to detect hrHPV in the anal scrapes.
Results. The highest detection rate of hrHPV was recorded in HIV-positive men having sex with men (MSM) (79.5%), and the lowest rate was found in HIV-negative heterosexual men (3.4%). The intermediate place was occupied by HIV-negative MSM (54.5%) and HIV-positive heterosexual men (22.4%). In the HIV-positive MSM group, several (2 to 9) hrHPV genotypes were at once registered in 65.5% of cases, which was more often than in the other groups.
Conclusion. The high detection rate of hrHPV DNA in the epithelial cells of the anal canal in men determines the need for HPV test-based anal screening to identify 14 hrHPV genotypes in all MSM, regardless of their HIV status and in all HIV-infected men, regardless of their sexual behavior.
Literature
1. Valvo F., Ciurlia E., Avuzzi B., Doci R., Ducreux M., Roelofsen F., Roth A., Trama A., Wittekind C., Bosset J.F. Cancer of the anal region. Crit. Rev. Oncol. Hematol. 2019; 135: 115–27. doi: 10.1016/j.critrevonc.2018.12.007 2. Каприн А.Д., Старинский В.В., Петров Г.В. (ред.). Состояние онкологической помощи населению России в 2018 году. М.: МНИОИ им. П.А. Герцена – филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2019. 236 с. ISBN 978-5-85502-250-6 Kaprin A.D., Starinsky V.V., Petrova G.V. (eds.). [The state of cancer care in Russia in 2018]. Moscow, 2019. 236 p. ISBN 978-5-85502-250-6 (In Russ.). http://aidsinfo.nih.gov/guidelines 3. Покровский В.В., Беляева В.В., Ермак Т.Н., Зимина В.Н., Канестри В.Г., Козырина Н.В., Кравченко А.В., Попова А.А., Шахгильдян В.И., Юрин О.Г. ВИЧ-инфекция и СПИД. Клинические рекомендации. М.: ГЭОТАР-Медиа, 2019. ISBN 978-5-9704-4869-4 Pokrovsky V.V., Belyaeva V.V., Ermak T.N., Zimina V.N., Kanestri V.G., Kozyrina N.V., Kravchenko A.V., Popova A.A., Shakhgildyan V.I., Yurin O.G. [HIV infection and AIDS. Clinical recommendations]. Moscow: GEOTAR-Media, 2019. ISBN 978-5-9704-4869-4 (In Russ.). 4. Weber R., Ruppik M., Rickenbach M., Spoerri A., Furrer H., Battegay M. et al. Decreasing mortality and changing patterns of causes of death in the Swiss HIV Cohort Study. HIV Med. 2013; 14(4): 195–207. DOI: 10.1111/j.1468-1293.2012.01051.x 5. Farahani M., Mulinder H., Farahani A., Marlink R. Prevalence and distribution of non-AIDS causes of death among HIV-infected individuals receiving antiretroviral therapy: a systematic review and meta-analysis. Int. J. STD AIDS 2017; 28(7): 636–50. DOI: 10.1177/0956462416632428 6. Chia-Chun Lin, Ming-Chang Hsieh, Hung-Chang Hung, Shih-Ming Tsao, Shiuan-Chih Chen et al. Human papillomavirus prevalence and behavioral risk factors among HIV-infected and HIV-uninfected men who have sex with men in Taiwan. Medicine (Baltimore) 2018; 97(45): e13201. doi: 10.1097/MD. 0000000000013201 7. Geskus R.B., González C., Torres M., Del Romero J., Viciana P., Masiá M. et al. Incidence and clearance of anal high-risk human papillomavirus in HIV-positive men who have sex with men: estimates and risk factors. AIDS 2016; 30(1): 37–44. 8. Parisi S.G., Basso M., Scaggiante R., Andreis S., Mengoli C., Cruciani M. et al. Oral and anal high-risk human papilloma virus infection in HIV-positive men who have sex with men over a 24-month longitudinal study: complexity and vaccine implications. BMC Public Health. 2019; 19(1): 645. doi: 10.1186/ s12889-019-7004-x 9. Kreuter A., Brockmeyer N.H., Hochdorfer B., Weissenborn S.J., Stücker M., Swoboda J. et al. Clinical Spectrum and Virologic Characteristics of Anal Intraepithelial Neoplasia in HIV Infection. J. Am. Acad. Dermatol. 2005; 52(4): 603–8. doi: 10.1016/j.jaad.2004.11.026
About the Autors
Anna A. Popova, Cand. Med. Sci., Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: asya-med@mail.ru; ORCID: https://orcid.org/0000-0001-9484-5917
Elvira A. Domonova, Cand. Biol. Sci., Senior Researcher, Department of Molecular Diagnosis and Epidemiology, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: еlvira.domonova@pcr.ms; ORCID: http://orcid.org/0000-0001-8262-3938
Anastasia V. Pokrovskaya, Cand. Med. Sci., Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: pokrovskaya_av@mail.ru; ORCID: http://orcid.org/0000-0002-2677-0404
Nadezhda А. Klimova, Junior Researcher, Department of Molecular Diagnosis and Epidemiology, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: klimova@cmd.su; ORCID: http://orcid.org/0000-0003-3288-0244
Olga Yu. Shipulina, Cand. Biol. Sci., Head, Subdivision of Molecular Diagnostic Methods, Department of Molecular Diagnosis and Epidemiology, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: olga.shipulina@pcr.ms; ORCID: http://orcid. org/0000-0003-4679-6772
Prof. Vadim V. Pokrovsky, MD, Academician of the Russian Academy of Sciences; Head, НIV Department, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: pokrovsky.vad@yandex.ru; ORCID: https://orcid.org/0000-0002-9514-7288
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