Experience of the use of molecular and biological monitoring in the epidemiological surveillance of meningococcal infection in Russia


DOI: https://dx.doi.org/10.18565/epidem.2019.9.1.93-9

Mironov K.O.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
Generalized forms of meningococcal infection (GFMI) are serious infectious diseases caused by bacteria of the Neisseria meningitidis species. Cyclic increase in the GFMI incidence, different incidence rates in certain territories and in different periods of time can be explained by antigenic and genetic features of circulating pathogens in some cases. Currently, in Russia and abroad, molecular-biological approaches are actively used to monitor GFMI pathogens, aimed at identifying sequencing types and clone complexes within representatives of known serogroups in order to determine their role in the epidemic process. The review presents the main results obtained by domestic researchers, and updated previously outlined directions for further molecular and biological monitoring of GFMI pathogens.
Keywords: clone complex, multilocus sequencing-typing, W serogroups, A, massive parallel sequencing, B, generalized forms of meningococcal infection, C, Neisseria meningitidis
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Literature

  1. Pokrovsky V.I., Favorova L.A., Kostyukova N.N. [Meningococcal disease]. Moscow: Medicine, 1976. 275 p. (In Russ.).
  2. Koroleva I.S., Beloshitskiy G.V. [Meningococcal infection and purulent bacterial meningitis]. Moscow: Medicinskoe informacionnoe agentstvo, 2007. 112 p. (In Russ.).
  3. Fox A.J., Taha M.K., Vogel U. Standardized nonculture techniques recommended for European reference laboratories. FEMS Microbiol. Rev. 2007; 31(1): 84–8. DOI: 10.1111/j.1574-6976.2006.00048.x.
  4. [Meningococcal infection and purulent bacterial meningitis in the Russian Federation, 2017. Analytical Review]. Moscow, 2018. 40 p. (In Russ.).
  5. Kostukova N.N., Mironova T.K., Leshchinskaia E.V. [Microbiologic characteristics of meningococcal infections in Moscow during years of a periodic rise in incidence (1968–1971)]. Zhurnal Mikrobiologii, Epidemiologii i Immunologii 1974; (5): 29–32. (In Russ.).
  6. Platonov A.E., Shipulin G.A., Koroleva I.S., Shipulina O.Yu. [The prospects for the diagnosis of bacterial meningitis]. Zhurnal Mikrobiologii, Epidemiologii i Immunologii 1999; (2): 71–6. (In Russ.).
  7. Shipulin G.A., Manzenyuk I.N. [Contribution of the Central Research Institute of Epidemiology to the development of Russian molecular diagnosis]. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2014; (2): 21–7. (In Russ.).
  8. Pokrovsky V.I. [Means of optimizing the epidemiological surveillance of infectious diseases in the USSR]. Zhurnal Mikrobiologii, Epidemiologii i Immunologii 1986; (11): 3–7. (In Russ.).
  9. Kostukova N.N., Bekhalo V.A. [Meningococcal infection and carriage]. Epidemiologiya i vakcinoprofilaktika 2010; 6(55): 67–72. (In Russ.).
  10. Kostukova N.N., Bekhalo V.A. [From safe carriage to purulent meningitis]. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2013; (2): 46–52. (In Russ.).
  11. Tagachenkova T.A., Koroleva I.S., Mironov K.O., Lytkina I.N., Pyaeva A.P., Zakroyeva I.M., Zaikin V.L., Solovyeva L.Ya. [Meningococcal carriage in the foci of meningococcal infection]. Epidemiologiya i infektsionnye bolezni 2009; (4): 6–10. (In Russ.).
  12. Pokrovsky V.I., Cherkassky B.L. [Actual problems of epidemiology of infectious diseases]. Epidemiologiya i infektsionnye bolezni 1999; (2): 12–6. (In Russ.).
  13. Cherkassky B.L. [The system of epidemiological surveillance as a reflection of the structure of the epidemic process]. Zhurnal Mikrobiologii, Epidemiologii i Immunologii 1986; (11): 74–8. (In Russ.).
  14. Kovaleva E.P. [The social ecology concept of the epidemic process of B.L. Cherkaskiy]. Zhurnal Mikrobiologii, Epidemiologii i Immunologii 1989; (1): 83–6. (In Russ.).
  15. Simonova E.G. [Morden stage of development of the epidemiological surveillance and prospects of its improvement]. Epidemiologiya i vakcinoprofilaktika 2016; 4(95): 4–7. (In Russ.).
  16. Kostiukova N.N., Tumanian A.A., Babich E.M., Tatarnikov V.M., Sipacheva N.B. [The role and place of serologic research in the system of epidemiologic surveillance of meningococcal infection]. Zhurnal Mikrobiologii, Epidemiologii i Immunologii 1988; (11): 36–41. (In Russ.).
  17. Platonov A.E., Khatit S.M., Platonova O.V. [Vaccine prevention of meningococcal infection in the world and in Russia]. Epidemiologiya i vakcinoprofilaktika 2009; (5): 32–46. (In Russ.).
  18. Acevedo R., Bai X., Borrow R., Caugant D.A., Carlos J., Ceyhan M., Christensen H., Climent Y., De Wals P., Dinleyici E.C., Echaniz-Aviles G., Hakawi A., Kamiya H., Karachaliou A., Lucidarme J., Meiring S., Mironov K., Sáfadi M.A.P., Shao Z., Smith V., Steffen R., Stenmark B., Taha M.K., Trotter C., Vázquez J.A., Zhu B. The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide: epidemiology, surveillance, hypervirulent strains, antibiotic resistance and high-risk populations. Expert Rev. Vaccines. 2018. DOI: 10.1080/14760584.2019.1557520.
  19. Koroleva M.A., Pokrovsky V.I., Mironov K.O., Platonov A.E., Shipulin G.A., Beloshitsky G.V., Zakroeva I.M., Melnikova A.A., Koshkina N.A., Koroleva I.S. [Epidemiological monitoring of purulent bacterial meningitides: Historical and present-day aspects]. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2014; (2): 52–6. (In Russ.).
  20. Demina A.A. [Epidemiological surveillance of meningococcal infection and purulent bacterial meningitis]. Epidemiologiya i infektsionnye bolezni 1999; (2): 25–8. (In Russ.).
  21. Koroleva M.A., Mironov K.O., Koroleva I.S. [Epidemiological characteristics of generalized meningococcal infection caused by Neisseria meningitidis serogroup W in the world and in the Russian Federation]. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2018; (3): 16–23. (In Russ.). DOI: https://dx.doi.org/10.18565/epidem.2018.3.16–23.
  22. Mironov K.O., Platonov A.E., Korolеva I.S., Zakroеva I.M., Zaikin V.L., Solovyova L.Ya., Braslavskaya S.I., Shipulin G.A. [Genetic subgroups of Neisseria meningitidis serogroup A isolated from patients with disseminated forms of meningococcal infection in Moscow, 1969–2006]. Zhurnal Mikrobiologii, Epidemiologii i Immunologii 2008; (1): 7–12. (In Russ.).
  23. Jolley K.A., Bray J.E., Maiden M.C.J. Open-access bacterial population genomics: BIGSdb software, the PubMLST.org website and their applications. Wellcome Open Res. 2018; (3):124. DOI: 10.12688/wellcomeopenres.14826.1.
  24. Mironov K.O. [Clonal complex of Neisseria meningitidis, circulating in the regions of Russia and their role in epidemic process of meningococcal infection]. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2016; (6): 52–61. (In Russ.).
  25. Clonal complex designation. http://pubmlst.org/neisseria/info/complexes. shtml. Accessed December 21, 2018.
  26. Mironov K.O., Platonov A.E., Dribnokhodova O.P., Kuseva V.I., Shipulin G.A. [A method for determination of Neisseria meningitidis serogroup A, B, C and W by real-time PCR]. Zhurnal Mikrobiologii, Epidemiologii i Immunologii 2014; 6: 35–42. (In Russ.).
  27. Mironov K.O., Tagachenkova T.A., Koroleva I.S., Platonov A.E., Shipulin G.A. [Genetic characteristics of Neisseria meningitidis strains obtained from healthy carriers during meningococcal infection outbreaks]. Zhurnal Mikrobiologii, Epidemiologii i Immunologii 2011; (2): 22–9. (In Russ.).
  28. Matosova S.V., Mironov K.O., Platonov A.E., Shipulina O.Yu., Shipulin G.A., Nagibina M.V. Vengerov Yu.Yа. [Molecular biological monitoring of pathogens caused purulent bacterial meningitis at the present stage]. Infekcionnye bolezni: novosti, mneniya, obuchenie 2018; 7(1): 93–9. (In Russ.). DOI: 10.24411/2305-3496-2018-00012.
  29. Matosova S.V., Mironov K.O., Platonov A.E., Shipulina O.Yu., Nagibina M.V. Vengerov Yu.Yа., Chentsov V.B., Smirnova T.Yu., Soldatova I.A., Shipulin G.A. [Molecular biological monitoring of Neisseria meningitidis in Moscow in the period 2011 to 2015]. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2016; (2): 4–9. (In Russ.).
  30. Mironov K.O., Koroleva M.A., Platonov A.E., Koroleva I.S., Shipulin G.A. [Genetic typing of Neisseria meningitidis circulating in the regions of Russia]. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2013; (2): 36–40. (In Russ.).
  31. Mironov K.O., Platonov A.E., Koroleva I.S., Shipulin G.A. [Analysis of the Moscow population of Neisseria meningitidis strains by the method of multilocus sequencing-typing]. Zhurnal Mikrobiologii, Epidemiologii i Immunologii 2006; (2): 31–6. (In Russ.).
  32. Nagibina M.V., Vengerov Yu.Yа., Matosova S.V., Mironov K.O., Platonov A.E., Svistunova T.S., Chernyshov D.V., Smirnova T.Yu., Kadyshev V.A., Ryzhov G.E. [Invasive form of meningococcal disease caused by N. meningitidis serogroup W on the territory of Moscow in 2011–2016]. Infekcionnye bolezni: novosti, mneniya, obuchenie 2018; 7(1): 100–5. (In Russ.). DOI: 10.24411/2305-3496-2018-00013.
  33. Mironov K.O., Zhivotova V.A., Matosova S.V., Kuleshov K.V., Shipulina O.Yu., Goptar I.A., Valdohina A.V., Pimkina E.V., Koroleva M.A., Koroleva I.S., Platonov A.E., Shipulin G.A. [Whole genome characterization of Neisseria meningitidis serogroup W isolates, circulating in Moscow]. Epidemiologiya i vakcinoprofilaktika 2017; 4(95): 33–8. (In Russ.).


About the Autors

Konstantin O. Mironov, MD, Head, Scientific Group for Development of New Genetic Polymorphisms Detection Methods, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: mironov@pcr.ru; ОRCID: http://orcid.org/0000-0001-8207-9215


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