Epidemiological characteristics of generalized meningococcal infection caused by Neisseria meningitidis serogroup W in the world and in the Russian Federation


DOI: https://dx.doi.org/10.18565/epidem.2018.3.16-23

Koroleva M.A., Mironov K.O., Koroleva I.S.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
In many countries of the world, there is an increase in the incidence of generalized meningococcal infection caused by Neisseria meningitidis serogroup W (MenW). Foreign studies demonstrate the atypical clinical presentations of MenW, its affection of older age groups, and high mortality rates.
Objective. To assess the role of serogroup W, that is rare in Russia, in the epidemic process of MenW: to determine the age characteristics of patients with MenW, mortality rates, and to characterize Neisseria meningitidis serogroup W strains circulating in the Russian Federation.
Materials and methods. The data of Accounting Forms No. 1 (the incidence of MenW) of the Russian Reference Center for Monitoring Bacterial Meningitides over the period from 2005 to 2017 were used, which had been received from all territorial subjects of the Russian Federation. MenW strains were characterized using the results of earlier molecular genetic studies published in the PubMLST database (https://pubmlst.org/neisseria/).
Results. There was an annual rise in the number of MenW cases, a prevalence of older age patients over young pediatric ones, and a high mortality rate.
Conclusion. With the continued increase in the number of MenW cases and in the availability of a safe and effective vaccine, a decision must be made to increase vaccination against meningococcal infection to prevent further increases in its incidence rates.
Keywords: massive parallel sequencing, meningococcus serogroup W, generalized meningococcal infection, multilocus sequence typing, meningococcal infection
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For citations: Koroleva M.A., Mironov K.O., Koroleva I.S. Epidemiological characteristics of generalized meningococcal infection caused by Neisseria meningitidis serogroup W in the world and in the Russian Federation. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2018; (3):16–23


About the Autors

For correspondence:
Maria А. Koroleva, Cand. Med. Sci., Senior Researcher, Laboratory for Epidemiology of Meningococcal Infection and Purulent Bacterial Meningitis, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Address: 3a, Novogireevskaya St., Moscow 111123, Russia
Е-mail: korolevamaria389@gmail.com
ОRCID: http://orcid.org/0000-0002-2714-1191
Information about the authors:
Konstantin O. Mironov, MD, Head, Scientific Group for Development of New Methods of Detection of Genetic Polymorphisms, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: mironov@pcr.ru; ОRCID: http://orcid.org/0000-0001-8207-9215
Irina S. Koroleva, MD, Head, Laboratory for Epidemiology of Meningococcal Infection and Purulent Bacterial Meningitis, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; е-mail: irina-korol@yandex.ru; ОRCID: http://orcid.org/0000-0003-0578-146X


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