Manifestations of the epidemic process of meningococcal infection in the Omsk Region


Anpilova N.G., Koroleva I.S., Stasenko V.L., Vaitovich M.A.

1Board, Inspectorate for the Protection of Consumer Rights and Human Welfare in the Omsk Region, Omsk; 2Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, Moscow; 3Russian Reference Center for Bacterial Meningitis Monitoring, Moscow; 4Omsk State Medical Academy, Ministry of Health of Russia
Objective – to assess the epidemic situation of meningococcal infection in the Omsk Region. The incidence of generalized meningococcal infection (GMI) was retrospectively analyzed on the basis of its 726 notified cases. A total of 3057 serum samples taken from apparently healthy individuals in 2006–2011 were examined. Multilocus sequence typing meningococci was carried out in the Russian Reference Center for Bacterial Meningitis Monitoring: 8 Neisseria meningitidis strains were investigated. The incidence of GMI showed a marked downward trend in the Omsk Region in the last 13 years. The proportion of Neisseria meningitidis serogroups B (NMB) and C (NMC) were equal in the etiological structure of GMI; NMB constituted the highest proportion (52.0%) in the structure of deaths. Evaluation of meningococcal immunity revealed that specific antibodies in the protective titers against N. meningitidis serogroup А (NMA) and NMC were present in 4.8% and 0.7%, respectively, which was indicative of the low circulation of the above serogroups in the Omsk Region. A unique NMA strain with the sequence type ST-7639, which was not included in any of the known clonal complexes, was found. In the Omsk Region, the cases of meningococcal infection are sporadic and suggest an interepidemic period pattern. NMB and NMC were ascertained to be of great importance in the incidence of GMI, suggesting the significance of microbiological monitoring in the epidemiological infection surveillance system. The use of current methods for pathogen identification could reveal new NMA strains circulating in the Omsk Region.

About the Autors


Anpilova Natalia Georgievna, Principal Searching Authority, Department of Epidemiological Surveillance, Board, Inspectorate for the Protection of Consumer Rights and Human Welfare in the Omsk Region
Address: 98, 10 Let Oktyabrya St., Omsk 644001
Telephone: (3812) 32-62-15
E-mail: epidotdel@55.rospotrebnadzor.ru


Similar Articles


Бионика Медиа