The epidemiological, clinical, and diagnostic aspects of tuberculosis concurrent with HIV infection in the Republic of Guinea


DOI: https://dx.doi.org/10.18565/epidem.2018.3.41-6

Воirо M.Y., Ван N.M., Konstantinov O.K., Cissé F., Kalivogui S., Sangare M.

1 Research Institute of Applied Biology of Guinea, Kindia, Republic of Guinea; 2 Ignace Deen National Hospital, Conakry, Republic of Guinea; 3 National Tuberculosis Control Programme, Conakry, Republic of Guinea
Objective. To study the epidemiological, clinical, and diagnostic aspects of tuberculosis (TB) concurrent with HIV infection in the Republic of Guinea.
Subjects and methods. A total of 646 patients with lung diseases partially associated with HIV infection were examined in the healthcare facilities of Kindia, Dubreka, and Conakry (Republic of Guinea). Pulmonary TB was diagnosed by microscopy, culture, and X-ray study. The patients’ blood HIV antibodies were determined by an enzyme immunoassay and confirmed by Western blotting. The epidemiological, clinical, and diagnostic aspects of these concomitant diseases were assessed.
Results. Pulmonary TB was diagnosed in 200 patients. It was found that there were HIV-1 (80%), HIV-2 (15%), and HIV-3 (5%) strains. The proportion of patients with HIV infection concurrent with TB in the healthcare facilities was 50% in Kindia, 17.2% in Dubreka, and 15.7% in Conakry. Among the patients there were slightly more women, the latter (housewives) prevailed among 11 social and professional groups of patients. Persons aged 15–44 years are at the greatest risk of infection. The patients had typical clinical signs of TB. X-rays revealed a predominant shadow of the lung base (40%). Among concomitant diseases, tropical malaria (69.4%) and intestinal parasitoses (40%) were predominant in TB patients at the Conakry hospital. Among opportunistic infections, there was anemia (92.4%), candidiasis of the gastrointestinal tract (61.2%), dermatosis (3.5%), toxoplasmosis (3.5%), and Kaposi’s sarcoma (2.3%).
Conclusion. Since the classical techniques for TB diagnosis are laborious, low-sensitive, and insufficiently specific, modern PCR diagnostic methods are most promising. But they are still unavailable in the country due to their high cost and a lack of trained of medical staff. In the future, the Research Institute of Applied Biology of the Republic of Guinea (RIABG) will master the new test systems developed in the State Research Center for Applied Microbiology and Biotechnology (Obolensk, Russia); all the more so as the RIABG employees have already undergone the training organized by the Federal Service for Supervision of Consumer Rights Protection and Human Well-Being of the Russian Federation. Genotyping of Mycobacterium tuberculosis isolates is scheduled, which will improve the quality of diagnosis of TB as a concomitant disease in HIV infection, as well as treatment regimens and TB epidemic surveillance in the Republic of Guinea.

Literature


  1. PNUD: Projeсt rеgional VIII et développement pour l’Afrique sub-saharienne. Avril 1996: 3–7.
  2. Engonah A.E., Toung M.M., Ramarojoanna S., Iba Ba J., Nkoghe D. Epidеmiologie de la tuberculose infantile au centre antituberculeux de Liberville de 1997 à 2001. Med Trop. 2006; 66: 469–71.
  3. Doumoua K. Complication pulmonaire et l’infection par le VIH en Afrique subsaharienne dans le service de pneumophtisiologie CHU de Treichville. Abidjan, Côte d’Ivoire, 1997; 79–84.
  4. Ouedraogo M. Pneumonie tuberculeuse en zone de forte prévalence tuberculeuse VIH au service de Pneumologie, Radiologie. Mеdicine interne Du Centre Hospitalier National Yalgado Ouedraogo et au service de Pneumologie du CHN Souro Sanou, 2003; 105–8.
  5. Zabsonre P., Ki Zerbo G.A., Bonkoungou P., Zoubga A., Nacro B., Dyemkouma F.X. Place de la tuberculose dans les péricardite infectieuse à liquide sérofibrineux ou hémorragique en milli hospitalier africain. Méd. Mal. Infect. 2002; 32: 163–70.
  6. Anonyme 1. Comité National de Lutte Contre le SIDA (CNLS), République de Guinée. Enquête démographique et de Santé Guinée. 2005 (EDSGIII). Prévalence du VIH. Соnakry, 2005.
  7. OMS. Bulletin de Santé. Rapport sur le santé 1997. Genève, 1997; 1–5.
  8. Global tuberculosis control : surveillance, planning, financing. WHO report 2008. Geneva, 2008. 294 p.
  9. Kornilova Z.H., Lukonina I.V., Alekseeva L.P. [Tuberculosis in combination with HIV infection]. Tuberculez i bolezni legkih 2010; (3): 3–9. (In Russ.).
  10. Bogoslovskaya E.V., Ermak T.N., Kuevda E.A., Kireev D.E. [HIV infection and opportunistic infections. In: Pokrovsky V.I., ed. Laboratory diagnosis of infectious diseases. Manual]. Мoscow: Binom, 2013; 18–21. (In Russ.).
  11. Ferront A. Bactériologie médicale à l’usage des étudiants en médicine. 13-e ed. Paris: Masson, 1989; 179.
  12. Le Minor L. Milieu d’isolement de bacilles Gram négative. Les entérobactéries I. 4-e еd. Paris: Flammarion, 1992. 164 р.
  13. Anonym 3. Ministère de la Santé et des Affaires Sociales. République Islamique de Mauritanie. Résultats de l’enquête sur la prévalence de l’infection VIH chez les femmes enceintes en consultation prénatale. Mauritanie. Nouachott Mai, 2002; 11–7.
  14. Fasquelle R. Elément de bactériologie médicale. 8th ed. Paris: Masson, 1969. 110 р.
  15. Raymond S.R. Travaux pratique de microbiologie. 2th еd. Maloine Sonabec, Montreal, Canada, 1974. 34 р.
  16. Alvares-Figeroa M.V., Ermak T.N. [Tuberculosis and mycobacteriosis. In: Pokrovsky V.I., ed. Laboratory diagnosis of infectious diseases. Manual]. Мoscow: Binom, 2013; 85–95. (In Russ.).
  17. Bessmertny B.S., Tkacheva M.N. [Statistical methods in epidemiology]. Moscow, 1961. URL: https://search.rsl.ru/ru/record/01005970121 (In Russ.).
  18. M’Boussa L. Prévalence de l’infection à VIH chez les tuberculeux à Brazzaville. Rev. Med. Trop. 1999; 59(2): 154.
  19. Renoux E., Barreh N.A., Sevre J.P., Mohamed A.I., Chami D., Vincent V. Tuberculeuse et infection VIH l’expérience du programme national de lutte antituberculeuse de Djibouti: 1990–1996. Rev. Med. Trop. 2002; 62(2): 171–6.
  20. Batungwanayo J., Taelman H., Bogaert J. Pneumopathies et infection à VIH à Kigali, Rwanda: intérêt du lavage bronchoalvéolaire et de la biopsie transbronchique pour le diagnostic étiologique. Kigali, 1996: 109–14.
  21. Mokrousov I.V. [Some features of genome structure and evolution of Mycobacterium tuberculosis]. Infektsiya i immunitet 2011; 1(3): 211–20. (In Russ.).
  22. Сoulibaly G. Prévalence de pneumocystose chez les sujets infectés par le VIH dans un service de pneumo-phtisiologie à Abidjan en Côte d’Ivoire. Abidjan, 1994: 116–20.
  23. Lamoureux E., Urmacher C. L’atteint pulmonaire dans le SIDA. Hôpital Paris, 1986: 3301–05.
  24. Rogeaux O., Gentilini M. Traitement des infections opportunistes au cours de l’infection à VIH. Hôpital Paris 1993: 133–8.
  25. Narvskaya O.V., Mokrousov I.V., Vyazovaya A.A. [Molecular epidemiological studies of the pathogen in the system of TB surveillance]. Infektsiya i immunitet 2013; 3(2): 156–7. (In Russ.).

For citations: Воirо M.Y., Ван N.M., Konstantinov O.K., Cissé F., Kalivogui S., Sangare M. The epidemiological, clinical, and diagnostic aspects of tuberculosis concurrent with HIV infection in the Republic of Guinea. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2018; (3):41–6


About the Autors


For correspondence:
Oleg K. Konstantinov, Cand. Biol. Sci., Researcher, Research Institute of Applied Biology of Guinea
Address: ВР 146, Kindia, Republic of Guinea
Tеlephone: (224) 655-098-833
E-mail: olegkonst@mail.ru
Information about the authors:
Prof. Boiro Mamadu Yero, PhD, Director-General, Research Institute of Applied Biology of Guinea, Kindia, Republic of Guinea; e-mail: myboiro@yahoo.fr
Bah Nene Mamata, PhD, Assistant, Ignace Deen National Hospital, Conakry, Republic of Guinea
Cissé F., PhD, Expert, National Tuberculosis Control Program, Conakry, Republic of Guinea
Kalivogui Siba, PhD, Deputy Director оf Research Institute of Applied Biology of Guinea, Kindia, Republic of Guinea; e-mail: sibakalivogui@yahoo.fr
Sangare Mori, Researcher, Research Institute of Applied Biology of Guinea, Kindia, Republic of Guinea; е-mail: Morisangare@yahoo.fr


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