Levels of hyperenzymemia in pregnant women with various infectious diseases


Kuzmin V.N., Adamyan L.V., Kharchenko E.I.

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia
Objective. To define the role of hepatotropic (HAV, HBV, HCV, and HDV) and conventionally hepatotropic
(HGV, CMV, EBV, HSV types 1, 2, and 6) viruses in the etiological structure of diseases in pregnant women, which are accompanied by enhanced blood ALAT and ASAT activities.
Subjects and methods. Examinations were made in 211 pregnant women; among them there were 123 patients with chronic viral hepatitis, 74 with enhanced blood ALAT activity in the absence of viral hepatitis markers (PAlAT-OMVG) and 14 with acute viral hepatitis. The examination was conducted by current test systems, such as enzyme immunoassay, chemiluminescence, and polymerase chain reaction.
Results. Among the pregnant women with chronic HBV and HCV infections, most cases were found to have blood HBV DNA and RNA, respectively, in the presence of both blood normal and increased transaminase activities. None of the conventionally hepatotropic viruses was identified in more than 7% of cases in the PAlAT-OMVG group. The genetic material from 10 patients with hepatitis of unspecified etiology exhibited no blood viruses, such as HAV, HBV, HCV, HDV, HGV, CMV, EBV, and HSV types 1, 2, and 6.
Conclusion. In the absence of serological findings confirming the presence of infectious diseases, blood PCR testing for conventionally hepatotropic viruses is of low informative value in pregnant women with hepatitis of unspecified etiology. However, taking into account the fact that the spectrum of conventionally hepatotropic viruses is not limited to those included in this investigation, it is advisable to additionally examine pregnant women with enhanced blood ALAT and ASAT activities for the viruses TTV, B19V, HSV-8, SEN, and NV-F.
Keywords: hepatotropic viruses, ASAT, ALAT, chronic viral hepatitis, pregnancy
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About the Autors

For correspondence:
Vladimir N. Kuzmin, МD, Professor, Department of Reproductive Medicine and Surgery, Faculty of Additional Professional Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia; Head, Center for Perinatal Infections; President, European Society for Infectious Diseases in Obstetrics and Gynecology (ESIDOG) in Russia
Аddress: 20, Delegatskaya St., Moscow 127473, Russia.
Telephone: +7(499) 390-57-78
E-mail: vnkuzmin@rambler.ru
Information about the authors:
Prof. Leila V. Adamyan, MD; Academician of the Russian Academy of Sciences, Honored Scientist of the Russian Federation; Principal Obstetrician/Gynecologist, Ministry of Health of Russia; Deputy Director of Science, Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; Deputy Director of Science,, Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; Head, Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Education, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia; e-mail: adamyanleila@gmail.com
Elmira I. Kharchenko, Cand. Med. Sci., Lecturer, Department of Reproductive Medicine and Surgery, Faculty of Additional Professional Education,, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia, Moscow, Russia; e-mail: hadeeva_elmira@inbox.ru


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