Myocardial damages in acute intestinal infections in children


Ruzhentsova T.A.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
Objective. To clarify the characteristics of myocardial changes developing in acute intestinal infections (AIIs).
Subjects and methods. A total of 2162 children with salmonellosis, rotavirus infection, salmonellosis/rotavirus infection, 232 with other AIIs, 428 with acute respiratory viral infections, and 60 healthy children were examined. Clinical, laboratory, electrocardiographic and echocardiographic abnormalities were assessed. To clarify changes, the investigation included 95 mice, of which 65 were infected with coxsackievirus A, 20 with salmonellosis, and 5 with influenza virus H3N2.
Results. Cardiac changes identified for the first time were detected in 20% of the patients with AIIs. Analysis of the myocardial histological pattern showed that dystrophy and inflammation were components of the common process.
Conclusion. The changes corresponding to myocarditis are detected in 10% of children with salmonellosis, in 18% of those with rotavirus infection, and in 37% of those with co-infection. Myocarditis is more commonly registered in 1- to 3-year-old children with mixed and severe AIIs. Functional changes are detected less frequently. In AIIs and influenza, the myocardium exhibits both dystrophic and inflammatory changes.
Keywords: aspartate aminotransferase, creatine kinase-MB, electrocardiography, transaminases, troponin I, myocarditis, echocardiography
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About the Autors

For correspondence:
Tatiana A. Ruzhentsova, МD, Leading Researcher, Clinical Department of Infectious Pathology, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Address: 3a, Novogireevskaya St., Moscow 111123, Russia
Telephone: +7(495) 672-11-58
E-mail: ruzhencova@gmail.com


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