Antiviral therapy for facial neuropathy associated with herpes simplex virus type 1


Ruzhentsova T.A., Khavkina D.A., Chukh­lyaev P.V.

1 Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 2 «REAVIZ» Moscow Medical University, Moscow, Russia
Previous investigations have shown the value of herpes simplex virus 1 (HSV-1) in the development of nervous system lesions. Lesions of cranial nerves occur in patients of any age and substantially disrupt a patient’s ability to work and quality of life. Facial neuropathy (Bell’s palsy) is most common. This disease is characterized by the high rate of detection of HSV-1 markers and by the efficiency of antiviral therapy. However, the high prevalence of HSV-1 infection in the population, including also among healthy individuals cannot be viewed as convincing evidence for the role of the virus in the development of Bell’s palsy. The paper gives a clinical example of Bell’s palsy developing in a 27-year-old female patient with an exacerbation of HSV-1-induced infection. The treatment with anti-inflammatory and neurotropic drugs in combination with microcirculation-improving agents and non-drug therapy were ineffective. Lower-grade fever, facial asymmetry complaints, and headache persisted after a cycle of treatment. Blood tests showed lymphocytosis and the higher titers of IgM and IgG antibodies to HSV-1. The use of acyclovir resulted in the relief of symptoms.
Keywords: Bell’s palsy, facial neuropathy, herpes simplex virus, acyclovir
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About the Autors

For correspondence:
Tatiana A. Ruzhentsova, МD, Leading Researcher, Clinical Department of Infectious Pathology, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Address: 3a, Novogireevskaya St., Moscow 111123, Russia
Telephone: +7(495) 672-11-58
E-mail: ruzhencova@ gmail.com
Information about the authors:
Daria A. Khavkina, Six-Year Student, Faculty of General Medicine, REAVIZ Moscow Medical University, Moscow, Russia; e-mail:havkina@gmail.com.
Pavel V. Chukhlyaev, Six-Year Student, Faculty of General Medicine, «REAVIZ» Moscow Medical University, Moscow, Russia; e-mail: pafachka@gmail.com


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