Русский
Features of clinical manifestations and laboratory diagnosis of tick-borne relapsing fever caused by Borrelia miyamotoi in the Novosibirsk Region
Krasnova E.I., Savelyeva M.V., Khokhlova N.I., Provorova V.V., Rar V.A., Melnikova O.V., Sabitova Yu.V., Tikunova N.V.
1Novosibirsk State Medical University, Ministry of Health of Russia, Novosibirsk, Russia; 2City Clinical Infectious Diseases Hospital One, Novosibirsk, Russia; 3Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia
Objective. To verify the diagnosis of borreliosis caused by B. miyamotoi in the dwellers of the Novosibirsk Region and to investigate its clinical and laboratory characteristics.
Materials and methods. 415 patients hospitalized with fever occurring after a tick bite were examined. Hemogram readings and serum biochemical parameters were analyzed. B. miyamotoi DNA from the patients’ blood was revealed by two-round PCR; the results were confirmed by sequencing the detected PCR fragments.
Results. Blood Asian type B. miyamotoi DNA was found in 9.6% of the examinees. The main manifestations of B. miyamotoi infections were fever and symptoms of intoxication in the absence of erythema migrans and signs of nervous system lesion. In borreliosis caused by B. miyamotoi, relative neutrocytosis and a stab shift in the white cell count were noted more frequently than those in Ixodes tick-borne borreliosis (p < 0.05). The increase in the activity of ALT and AST was slightly marked; the mean values of the transaminases were higher than those in the erythemal form of Ixodes tick-borne borreliosis (p < 0.05).
Conclusion. The findings are the basis for including B. miyamotoi test-systems in a set of techniques for screening tick-borne infections.
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About the Autors
For correspondence: Elena I. Krasnova, e-mail: Krasnova-inf@rambler.ru
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