HIV drug resistance: Dolutegravir is a second-generation HIV integrase inhibitor

Kravchenko A.V., Kanestri V.G.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow
The paper gives the results of two large international studies SALING and VIKING-3, on the basis of which dolutegravir (DTG) is recommended as part of second- and subsequent-line antiretroviral therapy (ART) regimens in case of ineffective previous treatment regimens incorporating not only protease or nonnucleoside reverse transcriptase inhibitors, but also first-generation HIV integrase inhibitor (II) [raltegravir (RAL) and elvitegravir (EVG)]. The SALING study has indicated that DTG used in combination with other antiretroviral drugs has a higher virologic efficacy and a higher genetic threshold to the development of resistance than RAL and is also well tolerated by previously treated patients. DTG used as part of an ART regimen using a higher daily dose (50 mg twice daily) (the VIKING-3 study) was effective and safe in patients having rich experience of therapy and HIV resistance to first-generation II (RAL and EVG) and viral multiple resistance to other classes of antiretroviral drugs.


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About the Autors

For correspondence:
Prof. Kravchenko Aleksey Viktorovich, MD; Leading Researcher, Specialized Research Department of AIDS Epidemiology and Prevention, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare
Address: 15, Eighth Sokolinaya Gora St., Build. 2, Moscow 105275
Telephone: +7(495) 366-05-18

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