Gender features of the development of cardiovascular risks in HIV-infected patients not receiving highly active antiretroviral therapy
Chukaeva I.I. Kravchenko A.V., Komarova I.V., Kushakova T.E., Saino O.V.
N.I. Pirogov Russian National Research Medical University, Moscow; Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, Moscow
HIV infection is a recognized risk factor for cardiovascular diseases. The role of maleness in HIV-infected patients has not been adequately studied.
Objective. To estimate the magnitude of traditional risk factors in HIV-infected patients of both sexes with the natural course of HIV infection.
Subjects and methods. Twenty-one patients with the natural course of HIV infection without cardiovascular diseases (a study group) were examined. The mean count of CD4+ lymphocytes was 399.05±159.47 cells/ml. A control group comprised 39 patients without HIV infection and cardiovascular diseases. The blood level of total cholesterol (TC), low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), high-density lipoproteins (HDL), triglycerides (TG), glucose, insulin, tumor necrosis factor-α (TNF-α), interleukin (IL)-12, and IL-18 were determined in all the patients. The plasma concentrations of TC, LDL, VLDL, HDL, TG, apolipoprotein B, and glucose were estimated by an Architect ci8200 biochemical autoanalyzer. The level of insulin was determined by an Immulite 2000 biochemical autoanalyzer. That of TNF-α, IL-12, and IL-18 was estimated by enzyme immunoassay using the standard plates.
Results. The women with the natural course of HIV infection were found to have significantly higher TC, LDL, and HDL levels than in the HIV-infected men. The men with the natural HIV infection had also a significantly lower level of these parameters than those from the control group.
Conclusion. Using the findings, it may be assumed that HIV infection erases gender differences in the development of cardiovascular risk factors, such as TC and LDL levels.
About the Autors
Prof. Chukayeva Irina Ivanovna, MD; Head, Polyclinic Therapy Department Two, Faculty of Therapeutics, N.I. Pirogov Russian National Research Medical University
Address: 1/1, Velozavodskaya St., Moscow 115280