Epidemiology and Infectious Diseases » Results of a survey of representatives of vulnerable groups for herpes simplex virus outside medical institutions (results of a pilot study in two regions of Russia)

Results of a survey of representatives of vulnerable groups for herpes simplex virus outside medical institutions (results of a pilot study in two regions of Russia)

DOI: https://dx.doi.org/10.18565/epidem.2024.14.3.60-6

Popova A.A., Domonova E.A., Skachkova T.S., Gromova A.V., Makhova T.I., Petrov A.S., Korenev D.A., Barsky K.A., Pokrovskaya A.V.
1) Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 2) Russian Medical Academy of Continuous Professional Education, Moscow, Russia; 3) Fund for the Prevention of Socially Significant Diseases «Steps», Moscow, Russia; 4) Peoples’ Friendship University of Russia named after Patrice Lumumba, Moscow, Russia

Background. Anogenital herpes has a negative impact on the quality of life, but in vulnerable groups it often remains undiagnosed, which leads to its spread and an increased risk of transmission of sexually transmitted infections, including HIV. This situation requires the implementation of different diagnostic and preventive approaches.
Objective. Assessment of the prevalence of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) in men with risky sexual behavior with investigation of various anatomical loci (oropharynx, anal canal, urogenital tract) outside medical institutions in two large regions of Russia (Moscow region and St. Petersburg).
Materials and methods. The study involved 564 representatives of vulnerable groups. Three types of biological material from three anatomical loci were examined: secretions from the mucous membrane of the oropharynx, anal canal, and the first portion of urine (urogenital tract). RT-PCR was used to determine HSV-1 and -2 DNA.
Results. HSV-1 and -2 DNA was detected in at least one studied locus in 58 (10.3%) of the examined subjects, including HSV-1 in 36 (62.0%) and HSV-2 in 22 (38.0%). The frequency of detection of HSV-1 and -2 in the anatomical loci was as follows: oropharynx in 35 (6.2%) of the examined subjects, anal canal - in 21 (3.7%), and the urogenital tract - in 6 (1.1%).
Conclusion. The frequency of HSV DNA detection among individuals with risky sexual behavior in two regions of the Russian Federation was 10.3% (95% CI 8.04–13.07). The prevalence of HSV-1 and HSV-2 among men who have sex with men, when examined outside medical institutions, was higher in the Moscow Region than in St. Petersburg (p = 0.03).

Keywords: individuals with risky sexual behavior, anogenital herpes, sexually transmitted infections, men, HIV infection

Read entire article

Literature

1. de Vries H.J.C., Nori A.V., Larsen H.K., Kreuter A., Padovese V., Pallawela S. et al. European Guideline on the management of proctitis, proctocolitis and enteritis caused by sexually transmissible pathogens. J. Eur. Acad. Dermatol. Venereol. 2021; 35(7): 1434–43. DOI: 10.1111/jdv.17269

2. Попова А.А., Покровская А.В., Шедько Е.Д., Громова А.В., Скачкова Т.С., Головешкина Е.Н. и др. Частота выявления инфекций, передаваемых половым путем, по результатам скрининга трех анатомических локусов у пациентов из групп риска. Эпидемиол. инфекц. болезни. Актуал. вопр. 2021; 11(4): 73–9. DOI: 10.18565/epidem.2021.11.4.73-9

Popova A.A., Pokrovskaya A.V., Shedko E.D., Gromova A.V., Skachkova T.S., Goloveshkina E.N. et al. [Detection rate for sexually transmitted infections by screening for three anatomic loci in at-risk patients]. Epidemiology and infectious diseases. Current items 2021; 11(4): 73–9. (In Russ.). DOI: 10.18565/epidem.2021.11.4.73-9

3. Махова Т.И., Громова А.В., Скачкова Т.С., Шедько Е.Д., Головешкина Е.Н., Попова А.А. и др. Частота выявления различных нарушений микробиоты влагалища и возбудителей инфекций, передаваемых половым путем, у женщин из группы риска Проблемы медицинской микологии 2021; 23(2): 112.

Makhova T.I., Gromova A.V., Skachkova T.S., Shedko E.D., Goloveshkina E.N., Popova A.A. et al. [Prevalence of various disorders of the vaginal microbiota and STI among women sex-workers]. Problems in Medical Mycology 2021; 23(2): 112. (In Russ.).

4 Тюленев Ю.А., Гущин А.Е., Кисина В.И. Особенности локализации инфекций, передаваемых половым путем, у субъективно асимптомных мужчин, практикующих секс с мужчинами. Клиническая дерматология и венерология 2021; 20(1): 55–61. DOI: 10.17116/klinderma20212001155

Tyulenev Yu.A., Guschin A.E., Kisina V.I. [Localization features of sexually transmitted infections in subjectively asymptomatic men who have sex with men]. Clinical Dermatology and Venereology 2021; 20(1): 55–61. (In Russ.). DOI: 10.17116/klinderma20212001155

5. Тюленев Ю.А., Титов И.С., Гущин А.Е. Высокая частота инфекций, передаваемых половым путем, среди мужчин, практикующих секс с мужчинами, обращающихся за проктологической помощью. Клиническая дерматология и венерология 2018; 17(3): 103–8. DOI: 10.17116/klinderma2018173109

Tyulenev Yu.A., Titov I.S., Gushchin A.E. [High incidence of sexually transmitted infections in men who have sex with men and visit proctology clinics]. Сlinical Dermatology and Venerology 2018; 17(3): 103–8. (In Russ.). DOI: 10.17116/klinderma2018173109

6. Домонова Э.А., Творогова М.Г., Подколзин А.Т., Шипулина О.Ю., Карань Л.С., Яцышина С.Б. и др. Взятие, транспортировка, хранение биологического материала для ПЦР-диагностики: Методические рекомендации. М.: ФБУН ЦНИИ эпидемиологии, 2021. 112 с. DOI: 10.36233/978-5-6045286-6-2

Domonova E.A., Tvorogova M.G., Podkolzin A.T., Shipulina O.Yu., Karan L.S., Yatsyshina S.B. et al. [Collection, transportation, storage of biological material for PCR diagnostics: guidelines] Moscow: Central Research Institute of Epidemiology, 2021. 112 p. (In Russ.). DOI: 10.36233/978-5-6045286-6-2

7. Rizza S., Mistrangelo M., Ribaldone D.G., Morino M., Astegiano M., Saracco G.M. et al. Proctitis: a glance beyond inflammatory bowel diseases. Minerva Gastroenterol. Dietol. 2020; 66(3): 252–66. DOI: 10.23736/S1121-421X.20.02670-7

8. James C., Harfouche М., Welton N.J., Turner K., Abu-Raddad L.J., Gottlieb S.L. et al. Herpes simplex virus: global infection prevalence and incidence estimates, 2016. Bull World Health Organ. 2020; 98(5): 315-329. DOI: 10.2471/BLT.19.237149

9. Bohl D.D., Katz K.A., Bernstein K., Wong E., Raymond H.F., J.D. Klausner, et al. Prevalence and correlates of herpes simplex virus type-2 infection among men who have sex with men, San Francisco, 2008. Sex Transm Dis. 2011; 38(7): 617-21. DOI: 10.1097/OLQ.0b013e31820a8c10.

10. Shi M., Zhang X., Chen M.. Prevalence of herpes simplex virus 2 among MSM in Mainland China: a systematic review and meta-synthesis. Meta-Analysis AIDS Res Ther. 2022; 19(1): 46. DOI: 10.1186/s12981-022-00469-w.

11. Workowski K.A., Bachmann L.H., Chan P.A., Johnston C.M., Muzny C.A., Park I. et al. Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recomm. Rep. 2021; 70(RR-4): 1–187. DOI: 10.15585/mmwr.rr7004a

12. Попова А.А., Домонова Э.А., Головешкина Е.Н., Громова А.В., Махова Т.И., Петров А.С. и др. Скрининг возбудителей ИППП в уязвимых группах вне медицинских учреждений: самостоятельное взятие мазка из анального канала. Эпидемиол. инфекц. болезни. Актуал. вопр. 2022; 12(3): 46–53. DOI:10.18565/epidem.2022.12/3/46-53

Popova A.A., Domonova E.A., Goloveshkina E.N., Gromova A.V., Makhova T.I., Petrov A.S. et al. [Screening for STI pathogens in vulnerable groups outside of healthcaare facilities: anal canal self-swabbing]. Epidemiоlоgy and infectious diseases. Сurrent items 2022; 12(3): 46–53. (In Russ.). DOI: 10.18565/epidem. 2022.12/3/46-53

13. Yared N., Horvath K., Fashanu O., Zhao R., Baker J., Kulasingam S. Optimizing Screening for Sexually Transmitted Infections in Men Using Self-Collected Swabs: A Systematic Review. Sex. Transm. Dis. 2018; 45 (Issue 5): 294–300. DOI: 10.1097/OLQ.0000000000000739

14. Templeton D.J., Wang Y., Higgins A.N., Manokaran N. Self-collected anal swabs in men who have sex with men: minimal benefit of routine peri-anal examination. Sex. Transm. Infect 2011; 87(3): 204. DOI: 10.1136/sti.2011.049346.

15. Ramchandani M.S., Golden M.R. Confronting Rising STIs in the Era of PrEP and Treatment as Prevention. Curr. HIV/AIDS Rep. 2019; 16(3): 244–56. DOI: 10.1007/s11904-019-00446-5

About the Autors

Anna A. Popova, Cand. Med. Sci., Senior Researcher, Department of Specialized Research Laboratory for AIDS Epidemiology and Prevention, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Moscow, Russia; Associate Professor, Department of Infectious Diseases, Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation, Moscow, Russia; asya-med@mail.ru; https://orcid.org/0000-0001-9484-5917
Elvira A. Domonova, Cand. Boil. Sci., Head, Scientific Group for the Development of New Methods for Diagnosis of Opportunistic and Human Papillomavirus Infections of the Department of Molecular Diagnostics and Epidemiology, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance of Consumer Rights Protection and Human Well-Being, Moscow, Russia; еlvira.domonova@pcr.ms; http://orcid.org/0000-0001-8262-3938
Tatyana S. Skachkova, Senior Researcher, Laboratory оf Molecular Diagnostics and Epidemiology of Reproductive Tract Infection, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Moscow, Russia; skachkova@cmd.su; https://orcid.org/0000-0003-1924-6521
Anastasia V. Gromova, Cand. Vet. Sci., Researcher Associate, Laboratory for Epidemiology of Reproductive Tract Infections, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Moscow, Russia; anastgromow@yandex.ru; https://orcid.org/0000-0003-4664-3178
Tamara I. Makhova, Researcher Associate, Laboratory for Epidemiology of Reproductive Tract Infections, Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being, Moscow, Russia; tamara.makhova89@gmail.com; https://orcid.org/0000-0001-7502-6473
Andrei S. Petrov, Spesialist of Social Work, Specialist of Work in Vulnerable Groups, Fund for Prevention of Socially Significant Diseases «Steps», Moscow, Russia; mosnomad@gmail.com
Dmitrii A. Korenev, Spesialist of Social Work, Administrator of Social Information Center «STEPS», Fund for Prevention of Socially Significant Diseases «Steps», Moscow, Russia; 1dmitrii.korenev@gmail.com
Kirill A. Barskiy, Spesialist of Public Health and Social Work, Head of the Programs and Projects, Fund for Prevention of Socially Significant Diseases «Steps», Moscow, Russia; barskiykirill@gmail.com
Anastasia V. Pokrovskaya, МD., Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Professor, Department of Infectious Diseases with Courses of Epidemiology and Phthisiology, Medical Institute, Peoples’ Friendship University, Moscow, Russia; pokrovskaya_av@mail.ru; http://orcid.org/0000-0002-2677-0404

Results of a survey of representatives of vulnerable groups for herpes simplex virus outside medical institutions (results of a pilot study in two regions of Russia)

Literature

About the Autors

Similar Articles