Русский
Prevalence of latent tuberculosis infection among contact persons in social homes
DOI: https://dx.doi.org/10.18565/epidem.2024.14.2.70-5
Khalafova E.T., Bogorodskaya E.M., Davidova N.G.
1) Moscow City Scientific and Practical Center for the Fight against Tuberculosis of the Moscow Healthcare Department, Moscow, Russia; 2) Russian Medical Academy of Continuous Professional Education, Moscow, Russia; 3) Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 4) Branch of the «Center for Hygiene and Epidemiology in Moscow» in Eastern Administrative District of Moscow, Russia
Materials and methods. An epidemiological investigation was carried out into 6 cases of tuberculosis without bacterial excretion registered in three social homes in Moscow. All contact persons, including staff, were examined at the Branch for the Eastern Administrative District and the North-East Administrative District of the Moscow City Scientific and Practical Center for the Fight against Tuberculosis of the Moscow Healthcare Department. Based on the examination results, contact persons were prescribed chemoprophylaxis with two combination drugs for 3 months.
Results. A total of 563 contact persons were identified in three social homes. LTBI was detected in 46 people, which amounted to 8.17% (95% CI 6.05–10.57). During the control test with the recombinant tuberculosis allergen in the 2nd year of follow-up, a decrease in the papule by 5 mm was noted in 7 (15.22%; 95% CI 6.42– 26.9) patients; results of tuberculin tests remained unchanged in 39 (84.78%; 95% CI 73.1–93.58) contact persons.
Conclusion. A patient with pulmonary tuberculosis without official confirmation of bacterial excretion is contagious. The detection rate of infected individuals in years by skin testing depends on the proximity of the contact to patient zero. Preventive therapy made it possible to prevent an outbreak of tuberculosis in social homes.
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About the Autors
Elvira T. Khalafova, Phthisiatrician, Acting Deputy Head for Medical Affairs, Moscow City Scientific and Practical Center for the Fight against Tuberculosis of the Moscow Healthcare Department, Moscow, Russia; orudzhova.elvira@bk.ru; https://orcid.org/0009-0007-8355-3581
Professor Elena M. Bogorodskaya, МD, Director, Moscow City Scientific and Practical Center for the Fight against Tuberculosis of the Moscow Healthcare Department; Head, Department of Phthisiology, Russian Medical Academy of Continuous Professional Education, Moscow, Russia;; BogorodskayaEM@zdrav.mos.ru; https://orcid.org/0000-0003-4552-5022
Natalia G. Davidova, Postgraduate Student, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; Epidemiologist, Branch of the «Center for Hygiene and Epidemiology in Moscow» in the Eastern Administrative District of Moscow, Russia; dawidowa.nat2016@yandex.ru; https://orcid.org/0000-0003-4429-9844
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