Clinical forms of tick-borne viral encephalitis in persons with co-infection


DOI: https://dx.doi.org/10.18565/epidem.2022.12.1.70-5

Bykov I.P., Sergeev A.G., Mishchenko V.A., Vyalykh I.V., Toporkova M.G., Vyatkina L.G., Makhorina T.V.

1) Yekaterinburg Research Institute of Viral Infections, State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Yekaterinburg, Russia; 2) «New Hospital» Medical Association, Yekaterinburg, Russia; 3) Ural State Medical University, Ministry of Health of Russia, Yekaterinburg, Russia
Objective. To identify the impact of tick-borne encephalitis-borreliosis co-infection (TBEBCI) on the incidence of severe forms of tick-borne viral encephalitis (TBVE) in patients with a history of different options for specific prevention, as well as in its absence.
Subjects and methods. Case histories were analyzed in patients with confirmed diagnoses of TBE (n = 246) and TBVEBCI (n = 208 cases).
Results. TBE was found to be associated with a mixed viral-bacterial infection of TBEBCI in 45.8% of cases. The incidence of severe focal forms of the disease was shown to be 1.5 times lower in the group of patients simultaneously infected with the two pathogens while the percentage of persons with mild febrile TBE was 1.4 times higher than in the group of patients with monoinfection, which suggests that the course of the disease associated with mixed infection is more favorable.
Conclusion. Ixodid TBEBCI reduces the risk of severe forms of TBE in patients with and with no history of different options for specific immunoprophylaxis against TBEV. The individuals vaccinated against TBE have the lowest risk of both TBE and TBVEBCI. At the same time, active immunization of the population most effectively protects the vaccinated against severe forms of the disease.

Literature


1. Малеев В.В., Ситников И.Г., Алешковская Е.С. Современные эпидемиологические аспекты клещевых трансмиссивных инфекций в Ярославской области. Эпидемиология и инфекционные болезни. Актуальные вопросы 2015; (3): 4–10.

Maleev V.V., Sitnikov I.G., Aleshkovskaya E.S. [Tick-transmitted infections in the Yaroslavl region: current epidemiological aspects]. Epidemiology and infectious diseases. Current items 2015; (3): 4–10. (In Russ.).


2. Миноранская Н.С., Миноранская Е.И. Клинико-эпидемиологическая характеристика микст-инфекции клещевого боррелиоза и клещевого энцефалита в Красноярском крае. Казанский медицинский журнал 2013; 94(2): 211–15.

Minoranskaya N.S., Minoranskaya E.I. [Clinical and epidemiologic characteristics of lyme borreliosis and tick-borne encephalitis mixed infections in Krasnoyarsk kray]. Kazan medical journal 2013; 94(2): 211–15. (In Russ.).


3. Castro L.R., Gabrielli S., Iori A., Cancrini G. Molecular detection of Rickettsia, Borrelia, and Babesia species in Ixodes ricinus sampled in northeastern, central, and insular areas of Italy. Experimental and Applied Acarology 2015; 66(3): 443–52. https://doi.org/10.1007/s10493-015-9899-y


4. Diuk-Wasser M.A., Vannier E., Krause P.J. Coinfection by Ixodes Tick-Borne Pathogens: Ecological, Epidemiological, and Clinical Consequences. Trends in Parasitology 2016; 32(1): 30–42. https://doi.org/10.1016/j.pt.2015.09.008


5. Raileanu C., Moutailler S., Pavel I., Porea D., Mihalca A.D., Savuta G., Vayssier-Taussat M. Borrelia Diversity and Co-infection with Other Tick-Borne Pathogens in Ticks. Frontiers in Cellular and Infection Microbiology 2017; 7 (36): 1–12. https://doi.org/10.3389/fcimb.2017.00036


6. Бондаренко А.Л., Зыкова И.В., Аббасова С.В., Тихомолова Е.Г., Нехорошкина Е.Л. Микст-инфекция клещевого энцефалита и иксодовых клещевых боррелиозов. Инфекционные болезни 2011; 9(4): 54–63.

Bondarenko A.L., Zykova I.V., Abbasova S.V., Tikhomolova E.G., Nekhoroshkina E.L. [Mixed infection of tick-borne encephalitis and ixodes tick-borne borrelioses]. Infectious Diseases 2011; 9(4): 54–63. (In Russ.).


7. Коренберг Э.И., Помелова В.Г., Осин Н.С. Природноочаговые инфекции, передающиеся иксодовыми клещами. M.: ООО Комментарий, 2013. 464 с.

Korenberg E.I., Pomelova V.G., Osin N.S. [Infections with natural focality transmitted by ixodid ticks]. Moscow: OOO Kommentarii, 2013. 464 p. (In Russ.).


8 Иерусалимский А.П. Клещевые инфекции в начале XXI века. Неврологический журнал 2009; 14 (3): 16–20.

Ierusalimsky A.P. [Tick-borne infections early in the XXIth century]. The Neurological Journal 2009; 14 (3): 16–20. (In Russ.).


9. Усков А.Н., Лобзин Ю.В., Бургасова О.А. Клещевой энцефалит, эрлихиоз, бабезиоз и другие актуальные клещевые инфекции в России. Инфекционные болезни 2010; 8 (2): 83–8.

Uskov A.N., Lobzin Yu.V., Burgasova O.A. [Tick-borne encephalitis, ehrlichiosis, babesiosis and other topical tick-borne infections in Russia]. Infectious Diseases 2010; 8(2): 83–8. (In Russ.).


10. Образцова Р.Г., Волкова Л.И., ред. Патоморфоз острого клещевого энцефалита на Среднем Урале. Екатеринбург: Изд-во УрГСХА, Уральское издательство, 2008. 228 с.

Obraztsova R.G., Volkova L.I., ed. [Pathomorphosis of Tick-borne encephalitis in Middle Ural]. Ekaterinburg: UrGSKhA, Ural’skoe izdatel’stvo, 2008. 228 p. (In Russ.).


11. Субботин А.В., Семенов В.А., Этенко Д.А. Проблема современных смешанных нейроинфекций, передающихся иксодовыми клещами. Архивъ внутренней медицины 2012; 2(4): 35–9.

Subbotin A.V., Semenov V.A., Etenko D.A. [The problem of modern mixed neuroinfections transmitted by ixodid ticks]. The Russian Archives of Internal Medicine 2012; 2 (4): 35–9. (In Russ.).


12. Быков И.П., Сергеев А.Г., Топоркова М.Г., Мищенко В.А., Задорожная И.А., Шлыкова Г.И. Популяционный иммунитет и патоморфоз клещевого вирусного энцефалита в условиях мегаполиса. Эпидемиол. инфекц. болезни. Актуал. вопр. 2019; 9(4): 20–7. https://dx.doi.org/10.18565/epidem.2019.9.4.20–7

Bykov I.P., Sergeev A.G., Toporkova M.G., Mishchenko V.A., Zadorozhnaya I.A., Shlykova G.I. [Herd immunity and pathomorphism of tick-borne viral encephalitis under the conditions of a megalopolis]. Epidemiology and infectious diseases. Current items 2019; 9(4): 20–7 (In Russ.). https://dx.doi.org/10.18565/ epidem.2019.9.4.20–7


13. Любезнова О.Н., Бондаренко А.Л. Клинико-эпидемиологические аспекты клещевого энцефалита в эндемичном регионе Европейской части России. Журнал инфектологии 2016; 8 (15): 32–9.

Lyubeznova O.N., Bondarenko A.L. [The clinical and epideiological features of tick-borne encephalitis at the endemical region of Russia’s European part]. Journal Infectology 2016; 8 (15): 32–9. (In Russ.).


14. Sergeant E.S.G. Epitools epidemiological calculators (2019). Ausvet Pty Ltd. http://epitools.ausvet.com.au


15. Hammer Ø., Harper D.A.T., Ryan P.D. PAST: Paleontological statistics software package for education and data analysis. Palaeontologia Electronica 2001; 4 (1): 9. http://palaeoelectronica.org/2001_1/past /issue1_01.htm


16. Громова О.А., Этенко Д.А., Семенов В.А., Субботин А.В. Диагностика смешанной инфекции клещевого энцефалита и клещевого боррелиоза на ранних этапах заболевания. Журнал неврологии и психиатрии им. C.C. Корсакова 2013; 113 (4): 9–12.

Gromova O.A., Etenko D.A., Semenov V.A., Subbotin A.V. [Diagnosis of mixed tick-borne encephalitis and tick-borne borreliosis in the early stages of the disease]. S.S. Korsakov Journal of Neurology and Psychiatry 2013; 113 (4): 9–12. (In Russ.).


17. Субботин А.В., Этенко Д.А., Семенов В.А., Щербинина М.С., Погодина В.В., Колясникова Н.М. и др. Случай заболевания смешанной клещевой инфекцией – клещевой энцефалит и боррелиоз (В. garinii, B. afzelii) в Кемеровской области. Медицина в Кузбассе 2017; 16 (4): 101–6.

Subbotin A.V., Etenco D.A., Semynov V.A., Shcherbinina M.S., Pogodina V.V., Kolyasnikova N.M. et al. [The case of mixed tick-borne infections – tick-borne encephalitis and lyme disease (B. garinii, B. afzelii) in the Kemerovo region]. Medicine in Kuzbass 2017; 16 (4): 101–6. (In Russ.).


18. Конькова-Рейдман А.Б., Злобин В.И. Сочетанная инфекция иксодового клещевого боррелиоза и клещевого энцефалита на Южном Урале. Челябинск: Тактик-Студио, 2016. 320 с.

Konkova-Reidman A.B., Zlobin V.I. [Co-infection of ixodic tick-borne borreliosis and tick-borne encephalitis in the Southern Urals]. Chelyabinsk: Taktik-Studio? 2016. 320 p. (In Russ.).


About the Autors


Ivan P. Bykov, Cand. Med. Sci., Senior Researcher, Laboratory of Transmissible Viral Infections and Tick-Borne Encephalitis, Yekaterinburg Research Institute of Viral Infections, State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Yekaterinburg, Russia; bykov_ip@eniivi.ru; https://orcid.org/0000-0002-5157-646X
Professor Aleksandr G. Sergeev, MD, Principal Researcher, Head, Department of Indication and Diagnosis of Viral Infections, Yekaterinburg Research Institute of Viral Infections, State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Ural State Medical University, Yekaterinburg, Russia; aldr131250@yandex.ru; https://orcid.org/0000-0002-5784-8673
Vladimir A. Mishchenko, Researcher, Laboratory of Transmissible Viral Infections and Tick-Borne Encephalitis, Yekaterinburg Research Institute of Viral Infections, State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Yekaterinburg, Russia; mischenko_va@eniivi.ru; https://orcid.org/0000-0003-4280-283X
Ivan V. Vyalykh, Cand. V. Sci., Leading Researcher, Head, Laboratory of Transmissible Viral Infections and Tick-Borne Encephalitis, Yekaterinburg Research Institute of Viral Infections, State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Yekaterinburg, Russia; vialykh_iv@eniivi.ru; https://orcid.org/0000-0002-3123-8359
Marina G. Toporkova, Cand. Med. Sci., Head, Department of Neurology, «New Hospital» Medical Association, Yekaterinburg, Russia; m.toporkova@newhospital.ru
Lyudmila G. Vyatkina, Medical Statistician, Ural-Siberian Research Guidance Center for Prevention of Healthcare-Associated Infections, Yekaterinburg Research Institute of Viral Infections, State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Yekaterinburg, Russia; vyatkina_lg@eniivi.ru; https://orcid.org/0000-0002-1944-3827
Tatiana V. Makhorina, Researcher, Laboratory of Transmissible Viral Infections and Tick-Borne Encephalitis, Yekaterinburg Research Institute of Viral Infections, State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Yekaterinburg, Russia; mahorina_tv@eniivi.ru; https://orcid.org/0000-0001-6126-9706


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