Русский
Clinical forms of tick-borne viral encephalitis in persons with co-infection
DOI: https://dx.doi.org/10.18565/epidem.2022.12.1.70-5
Bykov I.P., Sergeev A.G., Mishchenko V.A., Vyalykh I.V., Toporkova M.G., Vyatkina L.G., Makhorina T.V.
1) Yekaterinburg Research Institute of Viral Infections, State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Yekaterinburg, Russia; 2) «New Hospital» Medical Association, Yekaterinburg, Russia; 3) Ural State Medical University, Ministry of Health of Russia, Yekaterinburg, Russia
Subjects and methods. Case histories were analyzed in patients with confirmed diagnoses of TBE (n = 246) and TBVEBCI (n = 208 cases).
Results. TBE was found to be associated with a mixed viral-bacterial infection of TBEBCI in 45.8% of cases. The incidence of severe focal forms of the disease was shown to be 1.5 times lower in the group of patients simultaneously infected with the two pathogens while the percentage of persons with mild febrile TBE was 1.4 times higher than in the group of patients with monoinfection, which suggests that the course of the disease associated with mixed infection is more favorable.
Conclusion. Ixodid TBEBCI reduces the risk of severe forms of TBE in patients with and with no history of different options for specific immunoprophylaxis against TBEV. The individuals vaccinated against TBE have the lowest risk of both TBE and TBVEBCI. At the same time, active immunization of the population most effectively protects the vaccinated against severe forms of the disease.
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About the Autors
Ivan P. Bykov, Cand. Med. Sci., Senior Researcher, Laboratory of Transmissible Viral Infections and Tick-Borne Encephalitis, Yekaterinburg Research Institute of Viral Infections, State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Yekaterinburg, Russia; bykov_ip@eniivi.ru; https://orcid.org/0000-0002-5157-646X
Professor Aleksandr G. Sergeev, MD, Principal Researcher, Head, Department of Indication and Diagnosis of Viral Infections, Yekaterinburg Research Institute of Viral Infections, State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Ural State Medical University, Yekaterinburg, Russia; aldr131250@yandex.ru; https://orcid.org/0000-0002-5784-8673
Vladimir A. Mishchenko, Researcher, Laboratory of Transmissible Viral Infections and Tick-Borne Encephalitis, Yekaterinburg Research Institute of Viral Infections, State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Yekaterinburg, Russia; mischenko_va@eniivi.ru; https://orcid.org/0000-0003-4280-283X
Ivan V. Vyalykh, Cand. V. Sci., Leading Researcher, Head, Laboratory of Transmissible Viral Infections and Tick-Borne Encephalitis, Yekaterinburg Research Institute of Viral Infections, State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Yekaterinburg, Russia; vialykh_iv@eniivi.ru; https://orcid.org/0000-0002-3123-8359
Marina G. Toporkova, Cand. Med. Sci., Head, Department of Neurology, «New Hospital» Medical Association, Yekaterinburg, Russia; m.toporkova@newhospital.ru
Lyudmila G. Vyatkina, Medical Statistician, Ural-Siberian Research Guidance Center for Prevention of Healthcare-Associated Infections, Yekaterinburg Research Institute of Viral Infections, State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Yekaterinburg, Russia; vyatkina_lg@eniivi.ru; https://orcid.org/0000-0002-1944-3827
Tatiana V. Makhorina, Researcher, Laboratory of Transmissible Viral Infections and Tick-Borne Encephalitis, Yekaterinburg Research Institute of Viral Infections, State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Yekaterinburg, Russia; mahorina_tv@eniivi.ru; https://orcid.org/0000-0001-6126-9706
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