Mycoplasma pneumonia in hospitalized adult patients


DOI: https://dx.doi.org/10.18565/epidem.2021.11.1.30-6

Zhukova L.I., Nezhurin A.V., Popova A.V., Kovalevskaya O.I., Kozyreva E.V.

1) Specialized Clinical Infectious Diseases Hospital, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia; 2) Kuban State Medical University, Ministry of Health of Russia, Krasnodar, Russia
Objective. To provide the clinical and laboratory characteristics of mycoplasma pneumonia (MP) and to study the specific features of its treatment in adult patients hospitalized at a Krasnodar infectious diseases hospital.
Subjects and methods. The incidence and nature of clinical symptoms of MP confirmed by ELISA were retrospectively analyzed in 98 inpatients of the specialized clinical infectious diseases hospital in Krasnodar.
Results. MP is more common in young males and runs a moderate course in the cold season. The diagnostic signs of the disease are acute onset, wheezing on auscultation, weakness and malaise, nasopharyngeal hyperemia, rales in the lungs, fever, higher C-reactive protein levels, throat irritation, cough with scanty sputum, and enhanced LDH activity. Combination antibiotic therapy or monotherapy is indicated for patients with MP, by taking into account the susceptibility of mycoplasmas after verification of the diagnosis.
Conclusion. The incidence and absence of pathognomonic symptoms of MP make it advisable to include an enzyme immunoassay for anti-mycoplasma pneumoniae antibodies in the algorithm for examination of patients with pneumonia, which will be able to timely clarify the diagnosis and to correct etiotropic therapy.

Literature


1. Averуanov A.V. [Chlamydia and mycoplasma infections in pathology of the lower respiratory tract]. Lechebnoуe delo 2009; (4): 52–62. (In Russ.).


2. Lisin V.V., Korenуako I.E. [Respiratory Mycoplasmosis]. Мoscow, 1988. 77 p. (In Russ.).


3. Delуagin V.M., Blohin B.M., Mel’nikova M.A., Mel’nikova M.B. [Mycoplasma infection as an interdisciplinary problem]. Lechebnoуe delo 2006; (4): 3–9. (In Russ.).


4. Morozova N.V., Ostrovskaуa O.V., Holodok G.N., Morozova O.I., Nagovicyna E.B., Kozlov V.K. [Clinical and epidemiological characteristics of mycoplasma pneumonia in children]. Rossiуskiу Vestnik Perinatologii i Pediatrii 2012; 4(1): 50–4. (In Russ.).


5. Shhetinin E.V., Baturin V.A., Baturina M.V. [Is there a need to estimate the prevalence and effectiveness of antimicrobials? Problems of standardization in health care]. Problemy standartizacii v zdravoohranenii (1–2): 47–50. (In Russ.).


6. Shub G.M., Korzhenevich V.I., Luneva I.O. [Short course in medical microbiology]. Saratov, 2001. 342 p. (In Russ.).


7. Ostrovskaуa O.V., Holodok G.N., Morozova N.V., Ivahnishina N.M., Nagovicyna E.B., Vlasova M.A., Sidorchuk N.G. [The frequency of respiratory mycoplasmosis in children of the Khabarovsk Territory since 2004]. Dal’nevostochniy medicinskiy zhurnal 2016; (3): 50–3. (In Russ.).


8. Atkinson T.P., Balish M.F., Waites K.B. Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections. FEMSU Microbiol. Rev. 2008; 32(6): 956–73.


9. Chalker V.J., Stocki T., Mentasti M., et al. Mycoplasma pneumoniae infectionin primary careinves-tigated by real – time PCR in England and Wales. Eur. J. Clin. Microbiol. Infect. Dis. 2011; 30(7): 915–21.


10. Dekeyser S., Bonnel C., Martinet A., Descamps D. Usefullness of PCR test for the management of a Mycoplasma pneumoniae outbreak in Bethune Hospital (Pas de Calais, France). Pathol. Biol. (Paris). 2011; 59: 83–97.


11. Uldum S.A., Bangsborg J.M., Gahrn-Hansen B. et al. Epidemic of Mycoplasma pneumoniae infection in Denmark, 2010 and 2011. Euro Surveill. 2012; 17(5) ): 20073


12. Polkowska A., Harjunpaa A., Toikkanen S. et al. Increased incidence of Mycoplasma pneumoniae infection in Finland, 2010-2011. Euro Surveill. 2012; 17(5): 20072


13. Waites K.B., Talkington DF. Mycoplasma pneumoniae and its role as a human pathogen. Clin. Microbiol. Rev. 2004; 17(4): 697–728.


14. Kilicheva T.A. Razhapova N.R., Bojmatova N.P., Alimova M.M. [Mycoplasmal pneumonia]. Aktual’nye nauchnye issledovaniya v sovremennom mire 2017; 12(32): 26–32. (In Russ.).


15. Kuznechenkova T.V. [Genital mycoplasma infection in women of different social groups]. Vestnik NGU. Seriya: Biologiya, klinicheskaya medicina. 2010; 8(2): 78–82. (In Russ.).


16. Savenkova M.S., Savenkov M.P., Samitova Je.R., Bullih A.V., Zhuravleva I.A., Yakubov D.V., Kuznecova E.S. [Mycoplasma infection: clinical forms, features of the course, diagnostic errors]. Voprosy sovremennoу pediatrii 2013; 12(6): 108–14. (In Russ.).


17. Zaytseva S.V., Zastrozhina A.K., Murtazaeva O.A. [Mycoplasma infection in children (literature review)]. Russkiy medicinskiy zhurnal. Pediatriya 2017; (5): 327–34. (In Russ.).


18. Mal’ceva L.I, Zefirova T.P., Lobova L.A., Idijatullina Je.R., Fattahova A.R., Shishokina I.M. [Mycoplasma infection in obstetric and perinatal pathology]. Kazanskiy meditsinskiy zhurnal 2005; 86(2): 131–5. (In Russ.).


19. Zaplatnikov A.L., Maykova I.D., Lepiseva I.V. [Respiratory mycoplasmosis in the practice of a pediatrician]. Medicinskiy sovet 2016; (1): 157–61. (In Russ.).


20. Koshkarina E.A., Kvashnina D.V., SHirokova I. Yu. [Clinical, epidemiological and immunological characteristics of mycoplasmal pneumonia (analytical review)]. MediAl’ 2019; 1(23): 7–18. (In Russ.).


21. Dmitrieva I.V., Mamadashvili N.V., Kajb I.D., Petrushina A.D., Tropina E.T., Serokurova E.V., Kuz’micheva K.P., Glebov A.Yu., Kalashnikova O.A., Bekina D.D. [Clinical and laboratory features and antibiotic therapy of mycoplasma pneumonia in children]. Universitetskaya medicina Urala 2019; (2): 22–4. (In Russ.).


22. Ning Chen, Jianwei Shi, Jiaoling Huang, Wenya Yu, Rui Liu, Li Gu, Rong Yang, Zhaohu Yu, Qian Liu, Yan Yang, Sainan Cui, Zhaoxin Wang. Impact of air pollutants on pediatric admissions for Mycoplasma pneumoniaе: a cross-sectional study in Shanghai, China. BMC Public Health 2020; 20: 447. doi: 10.1186/s12889-020-8423-4


23. Shestakova I.V., Gorodin V.N., Kotova N.V. [The basics of the use of antibacterial drugs in the clinic of infectious diseases. A practical guide]. Moscow: OOO «Pre100 print», 2018. 192 р. (In Russ.).


About the Autors


Professor Larisa I. Zhukova, MD, Professor, Department of Infectious Diseases and Epidemiology, Faculty for Advanced Training and Professional Retraining of Specialists, Kuban State Medical University, Ministry of Health of Russia; Infectiologist, Specialized Clinical Infectious Diseases Hospital, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia; goukova@mail.ru; http://orcid.org/https://orcid.org/0000-0002-5306-2956
Andrey V. Nezhurin, Resident, Department of Infectious Diseases and Epidemiology, Faculty for Advanced Training and Professional Retraining of Specialists, Kuban State Medical University, Ministry of Health of Russia, Krasnodar, Russia; andrew_nezhurin@mail.ru
Anastasia V. Popova, Resident, Department of Infectious Diseases and Epidemiology, Faculty for Advanced Training and Professional Retraining of Specialists, Kuban State Medical University, Ministry of Health of Russia, Krasnodar, Russia; nastenka1hello@gmail.com
Olga I. Kovalevskaya, Unit Head, Specialized Clinical Infectious Diseases Hospital, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia; olga.kovalevskaya.67@mail.ru
Elena V. Kozyreva, Infectiologist, Specialized Clinical Infectious Diseases Hospital, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia; elenayantar@mail.ru


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