Assessment of awareness about a pre-exposure prophylaxis procedure in HIV-infected patients, their attitude towards its implementation, and prospects for its application in Russia


DOI: https://dx.doi.org/10.18565/epidem.2020.10.3.99-104

Efremova O.S., Bеlyaeva V.V., Kozyrina N.V., Kuimova U.A., Pokrovskaya A.V., Suvorova Z.K.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
Objective. To study the awareness of Russian HIV-infected patients about a pre-exposure prophylaxis (PrEP) procedure and the assessments of prospects for its application and to clarify their attitude to the latter.
Materials and methods. The study enrolled 96 patients infected with HIV. The investigators used a semi-structured interview that included indicators as open and closed questions, the answers to which could clarify the sociodemographic characteristics of the study participants and their awareness about prevention of HIV transmission.
Results. At the time of the interview, 61% of the respondents were unaware of the existence of the PrEP method. 16% of the respondents having discordant partners noted that they did not use HIV prevention methods. Most (77%) of the respondents expressed a positive attitude to the PrEP procedure; 10% reported that they did not think about this. 47, 29, and 24% assessed PrEP positively, doubtfully, and negatively respectively. The Internet was a primary source of information on PrEP for respondents; only 8% learned about the method from health workers.
Conclusion. It is advisable to monitor the risk of HIV transmission, by assessing the time course of changes in the characteristics of the risk behavior of patients who are followed up and receive ART. Emphasizing the cause-and-effect relationship between adherence to physician recommendations and a lower risk of HIV transmission during adherence counseling enhances the ability to shape a desirable behavior in patients. To promote this prevention method, it is necessary to elaborate a PtEP algorithm, in the structure of which a significant place should be given to information and advice on reducing the risk of HIV transmission.
Keywords: pre-exposure prophylaxis, attitude, awareness, HIV infection
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Literature

1. Building on the PrEP victory. Lancet. https://doi.org/10.1016/S0140-6736(20)30688-7


2. Покровский В.В., Юрин О.Г., Кравченко А.В., Беляева В.В., Ермак Т.Н., Канестри В.Г., Шахгиль­дян В.И., Козырина Н.В., Буравцова Е.Е., Нарсия Р.С., Покровская А.В., Ефремова О.С., Коннов В.В., Куи­мова У.А., Попова А.А., Хохлова О.Н., Воронин Е.Е., Афонина Л.Ю., Васильева И.А., Зимина В.Н.. Рекомен­дации по лечению ВИЧ-инфекции и связанных с ней заболеваний, химиопрофилактике заражения ВИЧ. Эпидемиол. инфекц. болезни. Актуал. вопр. 2018; (4, приложение). 80 с. https://epidemiology-journal.ru/ru/archive/edition/9974

Pokrovsky V.V., Yurin O.G., Kravchenko A.V., Belyaeva V.V., Ermak T.N., Kanestri V.G., Shakhgildyan V.I., Kozyrina N.V., Buravtsova E.E., Narsiуa R.S., Pokrovskaya A.V., Efremova O.S., Konnov V.V., Kuimova U.A., Popova A.A., Khokhlova O.N., Voronin E.E., Afonina L.Yu., Vasilieva I.A., Zimina V.N. [Recommendations for the treatment of HIV infection and related diseases, chemoprophylaxis of HIV infection]. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2018; (4, Suppl.). 80 р. (In Russ.). https://epidemiology-journal.ru/ru/archive/edition/9974


4. Grant R.M., Lama J.R., Anderson P.L., McMahan V., Liu A.Y., Vargas L. et al. Preexposure chemoprophylaxis for HIV prevention in men who have sex with men. N. Engl. J. Med. 2010; 363(27): 2587–99.


5. Dolling D., Desai M., Saunders J., Mackie N.E., Mcowan A., Elaney Y. et al. Who accesses PrEP? An analysis of baseline data in the PROUD pilot study. Third joint BHIVA/BASHH Conference. Liverpool, 2014. Аbstract 043. https://www.bhiva.org/file/IkrpDWCVFvuAf/AbstractBook2014.pdf


6. McCormack S., Dunn D. Pragmatic Open-Label Randomised Trial of Preexposure Prophylaxis: The PROUD Study. 2015. Conference on Retroviruses and Opportunistic Infections (CROI). Seattle, USA, 2015. Аbstract 22LB. https://www.croiconference.org/abstract/pragmatic-open-label-randomised-trial-preexposure-prophylaxis-proud-study/


7. Molina J-M.. Spire B., Pialoux G., Chidiac C. et al. On Demand PrEP With Oral TDF-FTC in MSM: Results of the ANRS Ipergay Trial. Conference on Retroviruses and Opportunistic Infections (CROI). Seattle, USA, 2015. Аbstract 23LB. https://www.croiconference.org/abstract/demand-prep-oral-tdf-ftc-msm-results-anrs-ipergay-trial/


8. Thigpen M., Kebaabetswe P.M., Smith D.K., Segolodi T. Daily oral antiretroviral use for the prevention of HIV infection in heterosexually active young adults in Botswana: results from the TDF2 study. Sixth International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention. Rome, 2011. Аbstract WELBC01. https://library.iasociety.org/Media View.aspx?media_id=4703


9. Baeten J., Heffron R., Kidoguchi L., Celum C. Near elimination of HIV transmission in a demonstration project of PrEP and ART. Conference on Retroviruses and Opportunistic Infections. Seattle, WA, USA, 23–26 February 2015. https://www.croiconference.org/abstract/near-elimination-hiv-transmission-demonstration-project-prep-and-art/


10. Choopanya K., Vanichseni S., Suntharasamai P., Martin M. et al. The Bangkok Tenofovir Study, an HIV pre-exposure prophylaxis trial in Thailand: participant adherence and study results.7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention. Kuala Lumpur, 2013. Аbstract WELBC05. http://www.aidsmap.com/news/jul-2013/bangkok-prep-study-finds-prep-efficacy-related-drug-exposure


11. Edelstein Z., Scanlin K., Findlater C., Salcuni P., Daskalakis D., Myers А. HIV Prevention Continuum among MSM, New York city, spring 2016. J. IAPAC 2017; Miami, FL Oral #27. https://www.iapac.org/Adherence Conference/presentations/ADH2017_OA270rev.pdf


12. Козырина Н.В., Беляева В.В., Хохлова О.Н., Суво­рова З.К., Оганесян Э.Э., Манукян Ю.А., Атаманчук А.А., Светогор Т.Н., Тойтукова М.М., Тостоков Э.Т., Муста­фаева Д.А., Бекметова М.Ю., Исмаилова Н.К., Шома­хмудова Ш.Ш., Аловутдинова Н.А. Методы контрацепции, используемые женщинами, живущими с ВИЧ, в 5 странах СНГ. Материалы международной научно-практической конференции «Актуальные вопросы ВИЧ-инфекции».10–11 июня 2019, Санкт-Петербург. СПб, 2019; 282–3. https://congress-ph.ru/common/ htdocs/upload/fm/vich/19/tezis.pdf

Kozyrina N. V., Belyaeva V. V., Khokhlova O. N., Suvorova Z.K.. Oganesyan E.E.. Manukyan Yu.A.. Ata­manchuk A.A.. Svetogor T.N.. Toytukova M.M.. Tostokov E.T.. Mustafayeva D.A.. Bekmetova M.Yu.. Ismailova N.K.. Shoma­khmudova Sh.Sh.. Alovutdinova N.A. [Contraceptive methods used by women living with HIV in 5 countries. Materials of the international scientific and practical conference «Actual issues of HIV infection»]. June 10–11, 2019. Saint Petersburg 2019; 282–3. (In Russ.). https://congress-ph.ru/common/htdocs/upload/fm/vich/19/tezis. pdf


13. Доконтактная профилактика (ДКП) в Восточной Европе и Центральной Азии: первые уроки. ЕСОМ, 2019. https://docs.google.com/ viewerng/ viewer? url=https://ecom.ngo/wp-content/uploads/2020/03/PrEP-Case-tudies _Report_RU. pdf&hl=ru

[Pre-exposure prophylaxis (PrEP) in Eastern Europe and Central Asia: first lessons]. EСOM, 2019. https://docs.google.com/viewerng/viewer?url=https://ecom.ngo/wp-content/uploads/2020/03/PrEP-Case-tudies_Report_ RU. pdf&hl=ru


About the Autors

Oksana S. Efremova, Cand. Med. Sci., Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: ks517@ yandex.ru; ORCID: https://orcid.org/ 0000-0001-5037-4041
Valentina V. Belyaeva, МD, Leading Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; е-mail: labora-et-ora@yandex.ru; ORCID: http://orcid.org/ 0000-0002-4621-7892
Nadezhda V. Kozyrina, Cand. Med. Sci., Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; е-mail: nad-kozyrina@yandex.ru; ORCID: http://orcid.org /0000-0001-5134-0054
Ulyana A. Kuimova, Cand. Med. Sci., Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: ulyanakuimova@gmail.com; ORCID: https://orcid. org/0000-0002-1101-151X
Anastasia V. Pokrovskaya, Cand. Med. Sci., Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; е-mail: pokrovskaya_av@mail.ru; ORCID: http://orcid.org/0000-0002-2677-0404
Zoya K. Suvorova, Cand. Med. Sci., Senior Researcher, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; е-mail: zksu@inbox.ru; ORCID: https://orcid. org/ 0000-0003-4055-289X


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