Treatment with the first Russian direct-acting antiviral drug in patients with chronic hepatitis C


DOI: https://dx.doi.org/10.18565/epidem.2019.9.4.77-83

Ponezheva Zh.B., Makashova V.V.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia
The review paper analyzes the latest data on the efficiency of narlaprevir in different antiviral treatment regimens for chronic hepatitis C (CHC). It presents the results of large-scale randomized trials in an extensive cohort of Russian patients using narlaprevir in combination with ritonavir in the interferon-containing and interferon-free regimens, by assessing its pharmacokinetics and profile of adverse events. The paper shows the stages of researches on the first Russian antiviral drug for the treatment of CHC. It gives combinations of narlaprevir with other drugs, its doses, and the duration of its treatment cycle in different antiviral therapy regimens.

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About the Autors


Zhanna B. Ponezheva, MD, Head, Clinical Department of Infectious Diseases, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; е-mail: doktorim@mail.ru, ORCID 0000-0002-6539-4878
Prof. Vera V.Makashova, MD, Leading Researcher, Clinical Department of Infectious Diseases, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; е-mail: veramakashova@yandex.ru; ORCID 0000-0002-3612-1889


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