Anti-NMDA receptor encephalitis


DOI: https://dx.doi.org/10.18565/epidem.2019.9.4.67-70

Ulukhanova L.U., Yaraliev M.M., Karnaeva N.S.

1) Dagestan State Medical University, Ministry of Health of Russia, Makhachkala, Russia; 2) S.M. Magomedov Dagestan Republican Center for Infectious Diseases, Prevention and Control of AIDS, Makhachkala, Russia
Absolutely healthy children of any age can spontaneously develop antibodies which bind to certain brain structures, the so-called N-methyl-D-aspartate (NMDA) receptors. The binding of these antibodies blocks the receptors and causes slowly progressive mental disorders, motor abnormalities, and seizures. The paper describes a clinical case of a disease in a 9-year-old female patient. The disease onset is marked by the manifestation of prodromal flu-like symptoms, fever, headache, and general weakness, followed by neuropsychiatric symptoms and impairments in memory and speech. Further progression of the disease caused convulsive status and later coma. The final diagnosis of autoimmune encephalitis was established after the complete blood count test identified anti-NMDA receptor antibodies.
Keywords: neuropsychiatric signs, convulsions, anti-N-methyl-D-aspartate (NMDA) receptor antibodies, encephalitis, children, treatment
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About the Autors

Lala U. Ulukhanova, MD, Head, Department of Propaedeutics of Children’s Diseases with a Course of Children’s Infections, Dagestan State Medical University, Ministry of Health of Russia, Makhachkala, Russia; е-mail: lala.uluhanova@mail.ru; ORCID: http://orcid.org/0000-0002-1311-079Х
Magomedzagir M. Yаraliev, Head, Resuscitation Department, S.M. Magomedov Dagestan Republican Center for Infectious Diseases, Prevention and Control of AIDS, Makhachkala, Russia; е-mail: zagir0668@mail.ru; ORCID: http://orcid.org/0000-0001-6488-3373
Nargiz S. Karnaeva, Cand. Med. Sci., Assistant Lecturer, Department of Propaedeutics of Childhood Diseases with Course of Childhood Infections, Dagestan State Medical University, Ministry of Health of Russia, Makhachkala, Russia; е-mail: karnaeva79@mail.ru; ORCID: http://orcid.org/0000-0001-7519-9235


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