Determination of the level of an immune stratum in the population of the Republic of Guinea to leptospirosis pathogens


DOI: https://dx.doi.org/10.18565/epidem.2019.9.2.39-43

Naydenova E.V., Kartashov M.Yu., Boyko A.V., Safronov V.A., Lopatin A.A., Kutyrev I.V., Bacar I., Boumbaly S., Kolomoets E.V., Kalivogui S., Boiro M.Y., Scherbakova S.A.

1) Russian Research Anti-Plague Institute «Microbe», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Saratov, Russia; 2) State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Koltsovo, Novosibirsk Region, Russia; 3) Anti-Plague Center, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 4) Research Institute of Applied Biology of Guinea, Kindia, Republic of Guinea; 5) United Company «RUSAL» (Russian Aluminum), Moscow, Russia
Objective. To determine the level of an immune stratum of the population in the Republic of Guinea to leptospirosis pathogens.
Subjects and methods. In the period May 2015 to March 2018, a total of 1839 serum samples were collected from people living in 4 landscape-geographical zones of Guinea: in the Lower (n = 693 samples), Medium (n = 461), Upper (n = 349), and Forest Guinea (n = 336).The investigation enrolled 904 (49.2%) women and 935 (50.8%) men, whose age was 0 to 90 years. The sera were studied at a working dilution of 1:100. Specific IgG antibodies in the sera were detected by enzyme immunoassay (EIA).
Results. Antibodies to Leptospira were detected in 90 (4.9%) samples, including 43 (47.7%) that were obtained from women and 47 (52.3%) from men in different age groups. Positive samples were recorded in all landscape-geographical areas of the country.
Conclusion. In the Republic of Guinea, the first IgG antibodies to Leptospira were identified in human sera and the level of an immune stratum of the population was determined. There is a need for further study of the spread of leptospirosis pathogens throughout the country; for epizootological monitoring to identify animal species carrying Leptospira, for investigation of the level of the stratum immune to the pathogen in cattle and small ruminants, and for monitoring open water bodies as possible sources of human infection. The findings will be able to determine the natural nidality of leptospirosis and to implement timely preventive (anti-epidemic) measures.
Keywords: immune stratum, IgG antibodies,  leptospirosis, Republic of Guinea
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About the Autors

Ekaterina V. Naydenova, Cand. Biol. Sci., Senior Researcher, Laboratory of Virology, Department of Communicable Diseases Diagnosis, Russian Research Anti-Plague Institute «Microbe», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Saratov, Russia;  e-mail: katim2003@mail.ru
Mikhail Yu. Kartashov, Cand. Biol. Sci., Junior Researcher, State Research Center of Virology and Biotechnology «Vector», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Koltsovo, Novosibirsk Region; e-mail: vector@vector.nsc.ru; ORCID ID 0000-0002-7857-6822
Andrey V. Boyko, MD, Leading Researcher, Laboratory of Virology, Department of Communicable Diseases Diagnosis, Russian Research Anti-Plague Institute «Microbe», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Saratov, Russia; e-mail: rusrapi@microbe.ru
Valentin А. Safronov, Cand. Med. Sci., Senior Researcher, Russian Research Anti-Plague Institute «Microbe», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Saratov, Russia; e-mail: rusrapi@microbe.ru
Anton А. Lopatin, Cand. Med. Sci., Director, Anti-Plague Centre, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; e-mail: protivochym@nln.ru
Ivan V. Kutyrev, Cand. Med. Sci., Researcher, Russian Research Anti-Plague Institute «Microbe», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Saratov, Russia; e-mail: rusrapi@microbe.ru
Bacar Ismail, Postgraduate Student, Research Institute of Applied Biology of Guinea, Kindia, Republic of Guinea
Boumbaly Sanaba, Cand. Biol. Sci., Director, Medical School, Research Institute of Applied Biology of Guinea, Kindia, Republic of Guinea; e-mail: drboumbaly@yahoo.fr; ORCID: https://orcid.org/0000-0002-4506-6033
Elena V. Kolomoets, Head, Medical Service, United Company «RUSAL» (Russian Aluminum), Moscow, Russia, e-mail: elena.kolomoets@rusal.com
Kalivogui Siba, Cand. Biol. Sci., Deputy Director, Research Institute of Applied Biology of Guinea, Kindia, Republic of Guinea; e-mail: sibakalivogui@yahoo.fr
Boiro Mamadu Yero, Cand. Biol. Sci., Professor, Director-General, Research Institute of Applied Biology of Guinea, Kindia, Republic of Guinea; e-mail: myboiro@ yahoo.fr; ORCID: https://orcid.org/0000-0003-3339-9380
Svetlana A. Scherbakova, BD, Deputy Director, Russian Research Anti-Plague Institute «Microbe», Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Saratov, Russia;  e-mail: shsveta@yandex.ru


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