Features of HHV-6A and HHV-6B infections in children living in the Moscow Region


DOI: https://dx.doi.org/10.18565/epidem.2018.2.42-9

Melekhina E.V., Lysenkova M.Yu., Svitich O.A., Muzyka A.D., Karazhas N.V., Rybalkina T.N., Boshyan R.E., Petukhova E.V., Chugunova O.L., Zverev V.V., Gorelov A.V.

1 Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; 2 Honored Academician N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia; 3 N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia; 4 I.I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia
Human herpes virus 6 (HHV-6) is one of the most common herpesviruses in a human population. Two HHV-6 types A and B, which differ in structure and clinical manifestations, have been taxonomically identified since 2012. In Russia, there are only a few studies of the clinical manifestations of HHV-6A and HHV-6B infections.
Objective. To describe the clinical features of HHV-6A and HHV-6B infections in children.
Subjects and methods. Examinations were made in 59 children aged 1 to 10 years with established HHV-6 infection. Among them, there were 14 clinically healthy children and 45 with manifestations of acute respiratory infection (ARI). A real-time PCR assay with TaqMan probes was used to type HHV-6.
Results. HHV-6A and HHV-6B infections occurred in 25 and 19 children with ARI, respectively. HHV-6B infection was dominant among the examined healthy children. HHV-6A infection more often affected children under 3 years old, causing fever with febrile seizures, rash, and upper respiratory tract lesion with catarrhal syndrome. HHV-6B infection more frequently induced acute infectious disease in children aged 3 years and older with the development of non-specific symptoms. In all age groups, HHV-6B infection was characterized by lymphoproliferative syndrome: peripheral lymphadenopathy, hepatomegaly, and lower respiratory tract lesion.
Conclusion. In the Moscow Region, children with the clinical manifestations of ARI are found to have both HHV-6A and HHV-6B, while the course of the disease has clinical features. HHV-6B prevails among healthy children.
Keywords: typing, HHV-6B, HHV-6A, acute respiratory disease, human herpesvirus 6
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For citations: Melekhina E.V., Lysenkova M.Yu., Svitich O.A., Muzyka A.D., Karazhas N.V., Rybalkina T.N., Boshyan R.E., Petukhova E.V., Chugunova O.L., Zverev V.V., Gorelov A.V. Features of HHV- 6A and HHV-6B infections in children living in the Moscow Region. Èpidemiologiâ i infekcionnye bolezni. Аktual’nye voprosy 2018; (2):42–9


About the Autors

For correspondence:
Еlena V. Melekhina – Cand. Med. Sci., Associate Professor in Pediatrics, Senior Researcher, Clinical Department of Infectious Diseases, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being
Address: 3a, Novogireevskaya St., Moscow 111123, Russia
Теlеphone: +7(495) 672-11-58
E-mail: e.melekhina@mail.ru
Information about the authors:
Mariya Yu. Lysenkova, Cand. Biol. Sci., Researcher, Laboratory of Epidemiology of Opportunistic Infections, Honored Academician N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia; е-mail: happydoctor-mk@mail.ru
Prof. Oksana A. Svitich, МD, Corresponding Member of the Russian Academy of Sciences, Head, Laboratory of Molecular Immunology, I.I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia; е-mail: svitichoa@yandex.ru
Anna D. Muzyka, Junior Researcher, Clinical Department of Infectious Diseases, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being,Moscow, Russia; е-mail: nikolitch-anna@yandex.ru
Prof. Nataliya V. Karazhas, BD, Head, Laboratory of Epidemiology of Opportunistic Infections, Honored Academician N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia;
е-mail: karazhas@ inbox.ru,
Tatiana N. Rybalkina, Cand. Biol. Sci., Researcher, Laboratory of Epidemiology of Opportunistic Infections, Honored Academician N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia; е-mail: rybalkinatn@mail.ru
Roman E. Boshyan, Cand. Biol. Sci., Researcher, Laboratory of Epidemiology of Opportunistic Infections, Honored Academician N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of Russia, Moscow, Russia; е-mail: rbrm@mail.ru
Evgeniya V. Petukhova, Junior Researcher, Clinical Department of Infectious Diseases, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; е-mail: tymrf@mail.ru
Prof. Olga L. Chugunova, МD, Academician V.A. Tabolin Department of Hospital Pediatrics, Pediatric Faculty, N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia, Moscow, Russia;
е-mail: ol_chugunova@mail.ru
Prof. Vitaly V. Zverev, BD, Acad. of the Russian Academy of Sciences; Director, I.I. Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia; е-mail: mech.inst@mail.ru
Prof. Alexandr V. Gorelov, MD, Corresponding Member of the Russian Academy of Sciences; Head, Clinical Department of Infectious Diseases, Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russia; е-mail: crie@pcr.ru


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