Tuberculosis screening using the recombinant tuberculosis allergen among adolescents and young adults


Baronova O.D., Odinetz V.S., Moiseeva N.N., Roudomakha L.V.

Territorial Clinical Tuberculosis Dispensary, Ministry of Health of the Stavropol Territory, Stavropol, Russia
Objective. To investigate the efficiency of the Mantoux test and recombinant tuberculosis allergen (RTA) test in identifying patients with tuberculosis among adolescents and young adults, who were students of the colleges and universities of Stavropol.
Subjects and methods. A total of 9,099 adolescents were examined using the Mantoux test (Stavropol, 2009–2011) and 18,597 students aged 15–25 years were screened using RTA (Stavropol, 2012–2016). The size of the groups at high risk for tuberculosis was estimated.
Results. Among the persons who had positive Mantoux tests, the hyperergic sensitivity to tuberculin was determined in 36 (0.4%) cases; one case of active tuberculosis was found; the detection rate was 0.1 per 1,000 examinations. Among those who had positive RTA tests, the hyperergic sensitivity was determined in 42 (23.5%) of the students; there were 3 cases of active tuberculosis and 10 cases of post-tuberculosis changes among the young people. The detection rate was 0.16 per 1,000 examinations, with 3.3 per 1,000 examinations among foreign students.
Conclusion. Screening using RTA showed its high efficiency in diagnosing active disease and latent tuberculosis infection in adolescents and young adults.

Literature


  1. Aksenova V.A., Sevostyanova T.A. [Tuberculosis in children and adolescents in Russia]. Lechashchiy vrach 2013; (1): 35–9. (In Russ.).
  2. Tsybikova E.B., Zubova N.A. [Efficiency evaluation of regular mass screening aimed at tuberculosis detection]. Tuberkulez I bolezni legkih 2016; (4): 13–9. (In Russ.). DOI:10.21292/2075-1230-2016-94-4-13-19
  3. Aksenova V.A., Baryshnikova L.A., Sevostyanova T.A., Klevno N.I. [Childhood tuberculosis in Russia, goals of the TB service and general pediatric service for TB prevention and early detection]. Tuberkulez I bolezni legkih 2014; (3): 40–6. (In Russ.).
  4. Baryshnikova L.A., Sirotko I.I., Ponomarev V.A., Katkova L.I., Kabaeva M.N. New opportunities for organizing early detection of tuberculosis in adolescents. Tuberkulez I bolezni legkih 2014; (8): 19. (In Russ.). DOI: 10.21292/2075-1230-2014-0-8-19-19
  5. Luginova E.F., Shepeleva L.P., Gurieva O.I. [Tendencies in tuberculosis situation among children in Sakha republic (Yakutia) during last 10 years when of new diagnostic tools have been introduced]. Tuberkulez I bolezni legkih 2017; (1): 5–9. (In Russ.). DOI: 10.21292/2075-1230-2017-95-1-5-10
  6. Dovgalyuk I.F., Korneva N.V., Starshinova A.A., Ovchinnikova Y.E., Ananyev S.M. [Clinical and epidemiological characteristics of registered childhood tuberculosis cases in the North-Western Region of Russia when introducing a tuberculosis diagnosis complex using diaskintest and multislice spiral computed tomography]. Tuberkulez I bolezni legkih 2015; (1): 4–8. (In Russ.). DOI:10.21292/2075-1230-2015-0-1-4-9
  7. Stogova N.A., Alimova O.S. [Risk factors of tuberculosis in higher educational establishments students]. Tuberkulez I bolezni legkih 2015; (5): 175–6. (In Russ.).
  8. Pozdeeva N.V., Kokovikhina I.A., Anikhovskaya O.N. [The use of diaskintest in diagnosing tuberculosis in adults]. Tuberkulez I bolezni legkih 2015; (6): 115. (In Russ.).
  9. Stas’ko E.Yu., Khasanshin G.S. [Analysis of use the skin test with tuberculosis recombinant allergen as a screening technique for children above 7 years old in Penza region in 2015]. Tuberkulez I bolezni legkih. 2016; (3): 52–6. (In Russ.).
  10. Shurygin A.A., Shirinkina A.E., Barmina N.A., Alekseeva Yu.A. [The results of a survey students of medical university with the use of the tuberculosis recombinant allergen]. Tuberkulez I bolezni legkih 2015; (7): 161–2. (In Russ.).


About the Autors


For correspondence:
Olga D. Baronova, Cand. Med. Sci., Deputy Chief Physician for Medical Care in the Outpatient Setting, Territorial Clinical Tuberculosis Dispensary, Ministry of Health of the Stavropol Territory
Address: 56, Dostoevsky St., Stavropol 355019, Russia
Теlеphоne/Fax: +7(8652) 28-69-52
E-mail: baronova_stav@mail.ru
Information about the authors:
Vasiliy S. Odinetz, Cand. Med. Sci., Honorary Physician of the Russian Federation, Chief Physician, Territorial Clinical Tuberculosis Dispensary, Ministry of Health of the Stavropol Territory, Stavropol, Russia; е-mail: info@kkptd.ru
Natalya N. Moiseeva, Cand. Med. Sci., Phthisiatrician, Territorial Clinical Tuberculosis Dispensary, Ministry of Health of the Stavropol Territory Stavropol, Russia; е-mail: mnmail@inbox.ru
Lydmila V. Rudomakha, Phthisiatrician, Territorial Clinical Tuberculosis Dispensary, Ministry of Health of the Stavropol Territory, Stavropol, Russia; е-mail: rudomaha_58@mail.ru


Similar Articles


Бионика Медиа