Multilocus sequencing typing of Haemophilus influenzae serotype b in the epidemiological Hib-meningitis surveillance in Russia


Mironov K.O.

Central Research Institute of Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Welfare, Moscow, Russia
Haemophilus influenzae serotype b bacteria belong to the common causative agents of purulent bacterial meningitis in children. An analysis of the information obtained using multilocus sequencing typing (MLST) allows genetic characterization of circulating pathogens and determination of the contribution of the representatives of these or those sequence types and clonal complexes in the epidemic process when retrospectively or prospectively assessing the epidemiological situation. The review provides an analysis of the results of using MLST to Russian H. influenzae serotype b isolates, which are available in the database http://pubmlst.org/hinfluenzae, and the epidemiological characteristics of the identified sequence types and clonal complexes.

Literature


1. Zverev V.V., Semenov B.F., Haitov R.M. (еds.). [Vaccines and vaccination: national guidelines]. Moscow: GEOTARMedia; 2011. 880 p. (In Russ.).

2. Platonov A.E., Koroleva I.S., Platonova O.V., Pokrovskiy V.I. [The incidence of purulent meningitis in children under 5 years in Moscow]. Epidemiologiya i Infektsionnye Bolezni 2006; (4): 36–43. (In Russ.).

3. Spirikhina L.V., Zakroyeva I.M., Koroleva I.S., Lytkina I.N., Pyaeva A.P. [Purulent bacterial meningitides of non-meningococcal etiology in Moscow in 2002–2010]. Ėpidemiologia i infekcionnye bolezni. Аktual’nye voprosy 2011; (3): 17–23. (In Russ.).

4. Peltola H. Worldwide Haemophilus influenzae type b disease at the beginning of the 21st century: global analysis of the disease burden 25 years after the use of the polysaccharide vaccine and a decade after the advent of conjugates. Clin. Microbiol. Rev. 2000; 13(2): 302–317.

5. Mironov K.O. [Clonal complexes of Neisseria meningitides circulating in the regions of Russia and their role in epidemic process of meningococcal infection]. Ėpidemiologia i infekcionnye bolezni. Аktual’nye voprosy 11. 2016; (6): 52–61. (In Russ.).

6. Platonov A.E., Shipulin G.A., Platonova O.V. [Multilocus sequencing – a new method of genotyping bacteria and first results of its use]. Genetika 2000; 36(5): 597–605. (In Russ.).

7. Feil E.J., Li B.C., Aanensen D.M., Hanage W.P., Spratt B.G. eBURST: Inferring Patterns of Evolutionary Descent among Clusters of Related Bacterial Genotypes from Multilocus Sequence Typing Data. J. Bacteriol. 2004; 186(5): 1518–30.

8. Jolley К.А., Maiden M.C.J. BIGSdb: Scalable analysis of bacterial genome variation at the population level. BMC Bioinformatics 2010; (11): 595.

9. Shipulin G.A., Manzenyuk I.N. [Contribution of the Central Research Institute of Epidemiology to the development of Russian molecular diagnosis]. Ėpidemiologia i infekcionnye bolezni. Аktual’nye voprosy 18. 2014; (2): 21–7. (In Russ.).

10. Mironov K.O., Platonov A.E., Koroleva I.S., Shipulin G.A. [Genetic relationships of Moscow and foreign strains of Haemophilus influenzae, serotype b]. Zhurnal Mikrobiologii, Epidemiologii i Immunologii 2006; (6): 14–20. (In Russ.).

11. Platonov A.E., Mironov K.O., Iatsyshina S.B., Koroleva I.S., Platonova O.V., Gushchin A.E., Shipulin G.A. [Multilocus sequence-typing for characterization of Moscow strains of Haemophilus influenzae type b]. Molekulyarnaya Genetika, Mikrobiologiya i Virusologiya 2003; (2): 21–5. (In Russ.).

12. Mironov K.O., Platonov A.E., Nikolaev M.K., Koroleva I.S., Shipulin G.A. [Genetic characteristic of Haemophilus influenzae type B strains isolated in Russian regions]. Zhurnal Mikrobiologii, Epidemiologii i Immunologii 2010; (1): 24–8. (In Russ.).

13. Mironov K.O., Tagachenkova T.A., Koroleva I.S., Platonov A.E., Shipulin G.A. [The results of genetic characteristics Neisseria meningitidis and Haemophilus influenzae serotype b (Hib)]. Medicinskiy Alfavit. Epidemiologiya i Sanitariya 2010; (2): 13–14. (In Russ.).

14. Platonov A.E., Nikolaev M.K. [The incidence of purulent meningitis in children under 5 years in the regions of Russia]. Epidemiologiya i Infektsionnye Bolezni 2007; (3): 10–8. (In Russ.).

15. [Epidemiology and vaccination of infection caused by Haemophilus influenzae type b. Methodological recommendations 3.3.1.0001-10]. Moscow: Rospotrebnadzor Publ.; 2010. (In Russ.).

16. Mironov K.O., Tagachenkova T.A., Platonov A.E., Iakovenko M.L., Koroleva I.S., Shipulin G.A. [Genetic characteristics of Haemophilus influenzae type b isolated from children with bacterial meningitis in Moscow in 2007-2009]. Zhurnal Mikrobiologii, Epidemiologii i Immunologii 2010; (4): 3–8. (In Russ.).

17. Meats E., Feil E.J., Stringer S., Cody A.J., Goldstein R., Kroll J.S., Popovic T., Spratt B.G. Characterization of encapsulated and noncapsulated Haemophilus influenzae and determination of phylogenetic relationships by multilocus sequence typing. J. Clin. Microbiol. 2003; 41(4): 1623–36.

18. Hunter P.R., Gaston M.A. Numerical index of the discriminatory ability of typing systems: an application of Simpson’s index of diversity. J. Clin. Microbiol. 1988; (26): 2465–66.

19. Musser J.M., Kroll J.S., Moxon E.R., Selander R.K. Clonal population structure of encapsulated Haemophilus influenzae. Infect. Immun. 1988; 56(8): 1837–45.

20. Erwin A.L., Sandstedt S.A., Bonthuis P.J., Geelhood J.L., Nelson K.L., Unrath W.C., Diggle M.A., Theodore M.J., Pleatman C.R., Mothershed E.A., Sacchi C.T., Mayer L.W., Gilsdorf J.R., Smith A.L. Analysis of genetic relatedness of Haemophilus influenzae isolates by multilocus sequence typing. J. Bacteriol. 2008; 190(4): 1473–83.

21. Deviatkina N.P., Il’ina T.V., Koroleva I.S., Martynov Iu.V., Demina A.A. [The characteristics of suppurative meningitis morbidity caused by Streptococcus pneumoniae and Haemophilus influenza type b]. Zhurnal Mikrobiologii, Epidemiologii i Immunologii 1990; (1): 45–49. (In Russ.).

22. Demina A.A. [Epidemiological surveillance of meningococcal infection and purulent bacterial meningitis]. Epidemiologiya i Infektsionnye Bolezni 1999; (2): 25–8. (In Russ.).

23. Koroleva I.S., Demina A.A., Platonov A.E., Beloshitskiy G.V., Gracheva A.M., Spirikhina L.V., Zakroyeva I.M., Mironov K.O., Bykova R.N. [Epidemiological surveillance for purulent bacterial meningitis: the results of the 20-yearold observations]. Epidemiologiya i Vakcinoprofilaktika 2003; (5): 10–3. (In Russ.).

24. Bennett J.V., Platonov A.E., Slack M.P.E., Mala P., Burton A.H., Robertson S.E. Haemophilus influenzae type b (Hib) meningitis in the pre-vaccine era: a global review of incidence, age distribution, and case-fatality rates. Document WHO/V&B/02.18. Geneva, World Health Organization, 2002; 1–92.

25. Cherkasskiy B.L. [Global epidemiology]. Moscow: Prakticheskaya medicina; 2008. 447 p. (In Russ.).


About the Autors


For correspondence: Konstantin O. Mironov, e-mail: mironov@pcr.ru


Similar Articles


Бионика Медиа