Serological monitoring of collective immunity to hemorrhagic fever with renal syndrome in the Republic of Tatarstan and a number of subjects of the Russian Federation


DOI: https://dx.doi.org/10.18565/epidem.2023.13.4.14-9

Savitskaya T.A., Trifonov V.A., Agafonova E.V., Isaeva G. Sh., Reshetnikova I.D., Petrova D.N.

1) Kazan Research Institute of Epidemiology and Microbiology of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Kazan, Russia; 2) Kazan State Medical University, Kazan, Russia; 3) Kazan (Volga Region) Federal University, Kazan, Russia
Objective. Assessment of the collective immunity of the population to pathogens of hemorrhagic fever with renal syndrome (HFRS) in the territory of the Republic of Tatarstan and a number of constituent entities of the Russian Federation.
Materials and methods. An analysis of the HFRS epidemic situation was carried out based on operational monitoring data of the Reference Center for HFRS Monitoring of the Kazan Research Institute of Epidemiology and Microbiology of Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, an using the information provided by Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being institutions in the constituent entities of the Russian Federation. Blood sera for the presence of specific IgG antibodies to HFRS pathogens were examined using the VectoHanta-IgG enzyme-linked immunosorbent test system (Novosibirsk, Russia) during 2012–2021. The quantile ranking method was used.
Results. The regions of the Republic of Tatarstan were ranked according to the seropositive sera level from individuals who did not have HFRS in the period 2012–2021. Serological studies of the collective immunity of the population of the Republics of Bashkortostan (2019, 2020), Udmurtia (2019), Ulyanovsk region (2019), Republic of Mordovia (2021), Kostroma (2021) and Chelyabinsk regions (2020, 2021) to HFRS pathogens were carried out.
Conclusion. The serological studies carried out made it possible to assess the state of natural immunity of the population to hantaviruses, which provides an objective assessment of the risk of infection of the population in endemic areas.

Literature


1. Савицкая Т.А., Трифонов В.А., Исаева Г.Ш., Решетникова И.Д., Пакскина Н.Д., Серова И.В. и др. Обзор современной эпидемиологической обстановки по заболеваемости геморрагической лихорадкой с почечным синдромом в мире и прогноз заболеваемости на территории Российской Федерации в 2019 г. Проблемы особо опасных инфекций 2019; (2): 30–6. DOI: 10.21055/0370-1069-2019-2-30-36


Savitskaya T.A., Trifonov V.A., Isaeva G.Sh., Reshetnikova I.D., Pakskina N.D., Serova I.V. et al. (Review of the current epidemiological situation on the incidence of hemorrhagic fever with renal syndrome in the world and the forecast of incidence in the Russian Federation in 2019). Problems of Particularly Dangerous Infections 2019; (2): 30–6. (In Russ.). DOI: 10.21055/0370-1069-2019-2-30-36


2. Савицкая Т.А., Иванова А.В., Чумачкова Е.А., Поспелов М.В., Исаева Г.Ш., Решетникова И.Д. и др. Обзор хантавирусных инфекций в мире, эпидемиологическая ситуация по геморрагической лихорадке с почечной Синдром в Российской Федерации в 2021 году и прогноз на 2022 год. Проблемы особо опасных инфекций 2022; (2): 54–63. DOI: 10.21055/0370-1069-2022-2-54-63


Savitskaya T.A., Ivanova A.V., Chumachkova E.A., Pospelov M.V., Isaeva G.Sh., Reshetnikova I.D. et al. (Overview of hantavirus infections in the world, the epidemiological situation of hemorrhagic fever with renal syndrome in the Russian Federation in 2021 and forecast for 2022). Problems of Particularly Dangerous Infections 2022; (2): 54–63. (In Russ.). DOI: 10.21055/0370-1069-2022-2-54-63


3. Ткаченко Е.А., Дзагурова Т.К., Бернштейн А.Д., Коротина Н.А., Окулова Н.М., Мутных Е.С. и др. Геморрагическая лихорадка с почечным синдромом (история, проблемы и перспективы изучения). Эпидемиология и Вакцинопрофилактика 2016; 15(3): 23–34. DOI:10.31631/2073-3046-2016-15-3-23-34


Tkachenko E.A., Dzagurova T.K., Bernstein A.D., Korotina N.A., Okulova N.M., Mutnykh E.S. et al. (Hemorrhagic fever with renal syndrome (history, problems and perspectives of the study)). Epidemiology and Vaccinal Prevention. 2016; 15(3): 23–34. (In Russ.). DOI:10.31631/2073-3046-2016-15-3-23-34


4. Фигурнов В.А., Гаврилов А.В., Марунич Н.А. Геморрагическая лихорадка с почечным синдромом в Амурской области. Благовещенск: Амурская государственная медицинская академия Минздрава РФ, 2016. 112 с.


Figurnov V.A., Gavrilov A.V., Marunich N.A. (Hemorrhagic fever with renal syndrome in the Amur region). Blagoveshchensk: изд-во?, Amur State Medical Academy of the Ministry of Health of the Russian Federation, 2016. 112 p. (In Russ.).


5. Нафеев А.А., Савельева Н.В., Сибаева Э.И. Иммунологический (серологический) мониторинг в системе эпидемиологического надзора за природно-очаговыми инфекциями. Эпидемиология и инфекционные болезни 2016; 21(5): 286–9. DOI 10.18821/1560-9529-2016-21-5-286-289


Nafeev A.A., Savelyeva N.V., Sibaeva E.I. (Immunological (serological) monitoring in the system of epidemiological surveillance of natural focal infections). Epidemiology and infectious diseases 2016; 21(5): 286–9. (In Russ.). DOI 10.18821/1560-9529-2016-21-5-286-289


6. Онищенко Г.Г., Кутырев В.В. Лабораторная диагностика опасных инфекционных болезней: Практическое руководство. 2-е изд. М.: Шико, 2013. 560 с.


Onishchenko G.G., Kutyrev V.V. (Laboratory diagnostics of dangerous infectious diseases: Practical guide). 2nd ed. Мoscow: Shiko, 2013. 560 p. (In Russ.).


7. Савицкая Т.А., Трифонов В.А., Агафонова Е.В., Тюрин Ю.А., Исаева Г.Ш., Решетникова И.Д. Серологический мониторинг в системе эпидемиологического надзора за природно-очаговыми инфекциями в Республике Татарстан. Эпидемиол. инфекц. болезни. Актуал. вопр. 2018; (1): 15–20.


Savitskaya T.A., Trifonov V.A., Agafonova E.V., Tyurin Yu.A., Isaeva G.Sh., Reshetnikova I.D. (Serological monitoring in the system of epidemiological surveillance of natural focal infections in the Republic of Tatarstan). Epidemiology and infectious diseases. Сurrent items 2018; (1): 15–20. (In Russ.).


8. Зинич Л.С., Коваленко И.С., Пидченко Н.Н., Тихонов С.Н. Эпидемиологическая значимость хантавирусной инфекции в Крыму. Проблемы особо опасных инфекций 2019; (2): 69–73. DOI: 10.21055/0370-1069-2019-2-69-73


Zinich L.S., Kovalenko I.S., Pidchenko N.N., Tikhonov S.N. (Epidemiological significance of hantavirus infection in the Crimea). Problems of Particularly Dangerous Infections 2019; (2): 69–73. (In Russ.). DOI: 10.21055/0370-1069-2019-2-69-73


9. Ступишин А.В., Бабанов Ю.В., Гусева А.А. Физико-географическое районирование Среднего Поволжья. Казань: Казанский университет 1964. 197 с.


Stupishin A.V., Babanov Yu.V., Guseva A.A. (Physical-geographical zoning of the Middle Volga region). Kazan: Kazan University, 1964. 197 p. (In Russ.).


10. Бакин О.В., Рогова Т.В., Ситников А.П. Сосудистые растения Татарстана. Казань: Изд-во КГУ, 2000. 496 с.


Bakin O.V., Rogova T.V., Sitnikov A.P. (Vascular plants of Tatarstan). Kazan: Publishing house of KGU, 2000 496 p. (In Russ.).


11. Ермолаев О.П., Игонин М.Е., Бубнов А.Ю., Павлова С.В. Ландшафты Республики Татарстан. Казань: Слово, 2007. 410 с.


Ermolaev O.P., Igonin M.E., Bubnov A.Yu., Pavlova S.V. (Landscapes of the Republic of Tatarstan). Kazan: Publishing house «Word», 2007. 410 p. (In Russ.).


12. Бойко А.А., Трифонов В.А., Решетникова И.Д., Агафонова Е.В., Исаева Г.Ш., Савицкая Т.А и др. Паразитарные комплексы, эпизоотическая активность, эпидемиологическое проявление природных очагов доминирующих зоонозов в формировании ландшафтных подзон Республики Татарстан (региональный экологический мониторинг, 1955–2015 гг.): коллективная монография. Казань: ЗАО «Алгоритм», 2021. 83 с.


Boyko A.A., Trifonov V.A., Reshetnikova I.D., Agafonova E.V., Isaeva G.Sh., Savitskaya T.A. et al. (Parasitic complexes, epizootic activity, epidemiological manifestation of natural foci of dominant zoonoses in the formation of landscape subzones of the Republic of Tatarstan (regional environmental monitoring, 1955–2015): collective monograph). Kazan: Algorithm, 2021. 83 p. (In Russ.).


13. Davidyuk Y.N., Kabwe E., Shamsutdinov A.F., Knyazeva A.V., Martynova, E.V., Ismagilova R.K. et al. The Distribution of Puumala orthohantavirus Genome Variants Correlates with the Regional Landscapes in the Trans-Kama Area of the Republic of Tatarstan. Pathogens 2021; (10), 1169. DOI:10.3390 /pathogens10091169


14. Калинина Э.Н., Мошкина А.А., Мошкин А.Б., Епифанцева Н.В. Клинико-эпидемиологические особенности ГЛПС в Забайкальском крае. Сибирское медицинское обозрение 2022; 2(134): 94–8. DOI:10. 20333/25000136-2022-2-94-98


Kalinina E.N., Moshkina A.A., Moshkin A.B., Epifantseva N.V. (Clinical and epidemiological features of HFRS in the Trans-Baikal Territory). Siberian Medical Review 2022; 2(134): 94–8. (In Russ.). DOI:10. 20333/25000136-2022-2-94-98


15. Козлова Е.Е., Ситникова Е.Е. Клинические проявления ГЛПС на современном этапе. Вятский медицинский вестник 2007; (1): 38–9.


Kozlova E.E., Sitnikova E.E. (Clinical manifestations of HFRS at the present stage). Vyatka Medical Bulletin 2007; (1): 38–9. (In Russ.).


16. Афанасьева В.И., Иванис В.А., Максема И.Г., Компанец Г.Г., Слонова Р.А. Особенности клинических проявлений ГЛПС в Приморском крае. Дезинфекционное дело 2011; (2): 22–5.


Afanas’eva V.I., Ivanis V.A., Maksema I.G., Kompanets G.G., Slonova R.A. (Features of clinical manifestations of HFRS in Primorsky Krai). Disinfection work 2011; (2): 22–5. (In Russ.).


17. Мурзабаева Р.Т., Мамон А.П., Хасанова Г.М., Кутлугужина Ф.Г., Шарифуллина Л.Д., Арсланова Р.Ф. Трудности ранней диагностики ГЛПС. Вестник Башкирского государственного медицинского университета 2019; (1): 227–31.


Murzabaeva R.T., Mamon A.P., Khasanova G.M., Kutluguzhina F.G., Sharifullina L.D., Arslanova R.F. (Difficulties in early diagnosis of HFRS). Bulletin of the Bashkir State Medical University 2019; (1): 227–31. (In Russ.).


About the Autors


Tatiana A. Savitskaya, Cand. Biol. Sci., Head, Laboratory of Epidemiology and Natural Focal Infections, Kazan Research Institute of Epidemiology and Microbiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Kazan, Russia; tatasav777@mail.ru; http:// orcid.org/0000-0002-6229-0387
Vladimir A. Trifonov, Cand. Med. Sci., Leading Researcher, Kazan Research Institute of Epidemiology and Microbiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Kazan, Russian Federation; vatrifonov@mail.ru; http://orcid.org/0000-0002-1810-1825
Elena V. Agafonova, Cand. Med. Sci., Head, Clinical Diagnostic Laboratory, Kazan Research Institute of Epidemiology and Microbiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Kazan, Russian Federation; Associate Professor, Kazan State Medical University, Ministry of Health of Russia, Kazan, Russia; agafono@mail.ru; http://orcid.org/0000-0002-4411-8786
Рrofessor Guzel S. Isaeva, MD, Deputy Director, Kazan Research Institute of Epidemiology and Microbiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Kazan, Russian; Head, Department of Microbiology, Kazan State Medical University, Ministry of Health of Russia, Kazan, Russia; guisaeva@rambler.ru; http://orcid.org/0000-0002-1462-8734
Irina D. Reshetnikova, Cand. Med. Sci., Deputy Director, Kazan Research Institute of Epidemiology and Microbiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Kazan, Russian; Associate Professor Kazan (Volga Region) Federal University, Kazan, Russia; reshira@mail.ru; http://orcid.org/0000-0002-3584-6861
Dina N. Petrova, Junior Researcher, Kazan Research Institute of Epidemiology and Microbiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Kazan, Russian; rcglps@yandex.ru; http://orcid.org/0000-0002-6682-0760


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