Clinical characteristics of non-polio enterovirus infections in adult inpatients from the Krasnodar Territory


DOI: https://dx.doi.org/10.18565/epidem.2022.12.4.34-9

Zhukova L.I., Shagina A.F., Rafeyenko G.K.

1) Kuban State Medical University, Ministry of Health of Russia, Krasnodar, Russia; 2) Specialized Clinical Infectious Diseases Hospital, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia; 3) Clinical Center for AIDS Prevention and Control, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia; 4) Center for Hygiene and Epidemiology in the the Krasnodar Territory, Krasnodar, Russia
Objective. To provide the clinical characteristics of non-polio enterovirus infections (NPEVIs) in adult inpatients from the Krasnodar Territory.
Subjects and methods. The clinical symptoms of verified NPEVI were retrospectively analyzed in 111 adult patients admitted to the Specialized Clinical Infectious Diseases Hospital, Ministry of Health of the Krasnodar Territory, in 2016–2019.
Results. Among the patients with NPEVI, young people with its moderate symptoms prevailed. More than half of the cases had this disease as exanthema of the mouth and extremities; the meningeal form occurred in a third of patients, NPEVI was the rarest form as an acute respiratory infection. The basic clinical signs of NPEVI in all its clinical forms were short-term febrile temperature, malaise, and weakness, upper respiratory tract symptoms, absolute monocytosis, and elevated C-reactive protein levels. In the meningeal form, the clinical and laboratory signs of serous meningitis were leading along with exanthema of the mouth and extremities - typical exanthema and enanthema.
Conclusion. NPEVIs are difficult to diagnose in terms of sporadic morbidity, as confirmed by the frequency of initial misdiagnoses (99.1%). In addition to the mandatory verification of the diagnosis of NPEVI, additional laboratory tests are required to rule out clinically similar diseases.

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About the Autors


Professor Larisa I. Zhukova, МD, Professor, Department of Infectious Diseases and Epidemiology, Kuban State Medical University, Ministry of Health of Russia; Infectiologist, Specialized Clinical Infectious Diseases Hospital, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia; goukova@mail.ru; https://orcid.org/0000-0002-5306-2956
Anfisa F. Shagina, Graduate Student, Department of Infectious Diseases and Epidemiology, Kuban State Medical University, Ministry of Health of Russia; Infectiologist, Clinical Center for AIDS Prevention and Control, Ministry of Health of the Krasnodar Territory; Krasnodar, Russia; anfisas@mail.ru, 204
Galina K. Rafeyenko, Graduate Student, Department of Infectious Diseases and Epidemiology, Kuban State Medical University, Ministry of Health of Russia; Deputy Chief Physician for Laboratory Activities, Center for Hygiene and Epidemiology in the Krasnodar Territory, Krasnodar, Russia; gorses@mail.kuban.ru


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