Русский
Clinical characteristics of non-polio enterovirus infections in adult inpatients from the Krasnodar Territory
DOI: https://dx.doi.org/10.18565/epidem.2022.12.4.34-9
Zhukova L.I., Shagina A.F., Rafeyenko G.K.
1) Kuban State Medical University, Ministry of Health of Russia, Krasnodar, Russia; 2) Specialized Clinical Infectious Diseases Hospital, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia; 3) Clinical Center for AIDS Prevention and Control, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia; 4) Center for Hygiene and Epidemiology in the the Krasnodar Territory, Krasnodar, Russia
Subjects and methods. The clinical symptoms of verified NPEVI were retrospectively analyzed in 111 adult patients admitted to the Specialized Clinical Infectious Diseases Hospital, Ministry of Health of the Krasnodar Territory, in 2016–2019.
Results. Among the patients with NPEVI, young people with its moderate symptoms prevailed. More than half of the cases had this disease as exanthema of the mouth and extremities; the meningeal form occurred in a third of patients, NPEVI was the rarest form as an acute respiratory infection. The basic clinical signs of NPEVI in all its clinical forms were short-term febrile temperature, malaise, and weakness, upper respiratory tract symptoms, absolute monocytosis, and elevated C-reactive protein levels. In the meningeal form, the clinical and laboratory signs of serous meningitis were leading along with exanthema of the mouth and extremities - typical exanthema and enanthema.
Conclusion. NPEVIs are difficult to diagnose in terms of sporadic morbidity, as confirmed by the frequency of initial misdiagnoses (99.1%). In addition to the mandatory verification of the diagnosis of NPEVI, additional laboratory tests are required to rule out clinically similar diseases.
Literature
1. Бутакова Л.В., Троценко О.Е., Сапега Е.Ю. Энтеровирусная инфекция: обзор ситуации в мире на современном этапе в условиях активизации миграционных процессов. Здоровье населения и среда обитания 2018; 301(4): 55–60. Butakova L.V., Trocenko O.E., Sapega E.YU. [Enterovirus infection: a review of the situation in the world at the present stage in the context of the activation of migration processes]. Public Health and Life Environment 2018; 301(4): 55–60. (In Russ.). 2. Анохин В.А. Энтеровирусные инфекции: современные особенности. Практическая медицина 2014; 85(9): 52–9. Anohin V.A. [Enterovirus infections: current features]. Practical medicine 2014; 85(9): 52–9. (In Russ.). 3. Жукова Л.И., Рафеенко Г.К., Шагина А.Ф., Ванюков А.А. Многолетний эпидемиологический мониторинг и клиническая характеристика неполиомиелитных энтеровирусных инфекций в Краснодарском крае. Эпидемиол. инфекц. болезни. Актуал вопр. 2021; 11(2): 22–8. DOI: 10.18565/epidem.2021.11.2.22–8 Zhukova L.I., Rafeenko G.K., Shagina A.F., Vanyukov A.A. [Long-term epidemiological monitoring and clinical characteristics of non-polio enterovirus infections in the Krasnodar Territory]. Epidemiology and infectious diseases. Current issues 2021; 11(2): 22–8. (In Russ.). DOI: 10.18565/epidem.2021.11.2.22–8 4. Усачева Е.В., Рябоконь Е.В., Камышный А.М., Задирака Д.А., Пахольчук Т.Н., Фирюлина О.М. Энтеровирусные инфекции: современные клинико-эпидемиологические особенности. Запорожский медицинский журнал 2017; 2: 162–7. DOI: 10.14739/2310-1210.2017.2.95681 Usachyova E.V., Ryabokon’ E.V., Kamyshnyj A.M., Zadiraka D.A., Pahol’chuk T.N., Firyulina O.M. [Enterovirus infections: modern clinical and epidemiological features]. Zaporozhye Medical Journal 2017; (2): 162–7. (In Russ.). DOI: 10.14739/2310-1210.2017.2.95681 5. Новикова Н.А., Голицына Л.Н., Фомина С.Г., Ефимов Е.И. Молекулярный мониторинг неполиомиелитных энтеровирусов на европейской территории России в 2008–2011 гг. Журнал микробиологии, эпидемиологии и иммунобиологии 2013; (1): 75–8. Novikova N.A., Golicyna L.N., Fomina S.G., Efimov E.I. [Molecular monitoring of non-polio enteroviruses in the European territory of Russia in 2008–2011]. Journal of Microbiology, Epidemiology and Immunobiology. 2013; (1): 75–8. (In Russ.). 6. Амвросьева Т.В., Поклонская Н.В., Богуш З.Ф., Глинская И.Н., Бискина Н.М., Жукова Н.П. Актуальные проблемы энтеровирусных инфекций в рамках единого эпидемического пространства. Инфекция и иммунитет 2017; (5): 105. Amvros’eva Т.V., Poklonskaya N.V., Bogush Z.F., Glinskaya I.N., Biskina N.M., Zhukova N.P. [Actual problems of enterovirus infections within a single epidemic space]. Infection and immunity 2017; (5): 105. (In Russ.). 7. Козловская О.В., Катанахова Л.Л., Камка Н.Н., Евсеева А.Н. Эпидемиологические, клинические и диагностические особенности энтеровирусной инфекции у детей и взрослых. Вестник СурГУ. Медицина 2018; 36(2): 56–60. Kozlovskaya O.V., Katanahova L.L., Kamka N.N., Evseeva A.N. [Epidemiological, clinical and diagnostic features of enterovirus infection in children and adults]. Bulletin of Surgut State University. Medicina 2018; 36(2): 56–60. (In Russ.). 8. Резник В.И., Присяжнюк Е.Н., Савосина Л.В., Лебедева Л.А., Жалейко З.П., Привалов С.И. Энтеровирусные инфекции в Хабаровском крае. Дальневосточный журнал инфекционной патологии 2018; 34: 53–69. Reznik V.I., Prisyazhnyuk E.N., Savosina L.V., Lebedeva L.A., ZHalejko Z.P., Privalov S.I. [Enterovirus infections in the Khabarovsk Territory]. Far Eastern Journal of Infectious Pathology 2018; 34: 53–69. (In Russ.). 9. Bowers J.R., Valentine M., Harrison V., Fofanov V.Y., Gillece J., Delisle J. et al. Genomic Analyses of Acute Flaccid Myelitis Cases among a Cluster in Arizona Provide Further Evidence of Enterovirus D68 Role. mBio 2019; 10(1): e02262-18. doi: 10.1128/mBio.02262-18 10. Mirand A., Cohen R., Bisseux M., Tomba S, Cahn S.F., Nathalie G. et al. A large-scale outbreak of hand, foot and mouth disease, France, as at 28 September 2021. Euro Surveill. 2021; 26(43): 427–37. https://doi.org/10.2807/1560-7917.ES.2021.26.43.2100978 11. Sioofy-Khojine A.-B., Oikarinen S., Honkanen H., Huhtala H., Lehtonen J.P., Briese T. et al. Molecular epidemiology of enteroviruses in young children at increased risk of type 1 diabetes. PLoS One 2018; 13(9): e0201959. DOI: 10.1371/journal.pone.0201959 12. Агеева О.Т., Сергачева И.П., Швецова О.П. Современные методы лабораторной диагностики энтеровирусной инфекции. Научно-медицинский вестник Центрального Черноземья 2014; 57: 3–6. Ageeva O.T., Sergachyova I.P., Shvecova O.P. [Modern methods of laboratory diagnosis of enterovirus infection]. Scientific and Medical Bulletin of the Central Chernozem Region 2014; 57: 3–6. (In Russ.). 13. Benschop K.S.M., Jan A., Andres A., Andrés C., Aranzamendi M., Armannsdóttir B. et al. Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021. Euro Surveill. 2021; 26(45): 427–37. https://doi.org/10.2807/1560-7917.ES.2021.26.45.2100998 14. Zhu P., Chen S., Zhang W., Duan G., Jin Y. Essential Role of Non-Coding RNAs in Enterovirus Infection: From Basic Mechanisms to Clinical Prospects. Int. J. Mol. Sci. 2021; 22, 2904. https://doi.org/10.3390/ ijms22062904 15. Marjomäki V., Kalander K., Hellman M., Permi M. Enteroviruses and coronaviruses: similarities and therapeutic targets. Expert Opin. Ther. Target. 2021; 25(6): 479–89. DOI: 10.1080/14728222.2021.1952985
About the Autors
Professor Larisa I. Zhukova, МD, Professor, Department of Infectious Diseases and Epidemiology, Kuban State Medical University, Ministry of Health of Russia; Infectiologist, Specialized Clinical Infectious Diseases Hospital, Ministry of Health of the Krasnodar Territory, Krasnodar, Russia; goukova@mail.ru; https://orcid.org/0000-0002-5306-2956
Anfisa F. Shagina, Graduate Student, Department of Infectious Diseases and Epidemiology, Kuban State Medical University, Ministry of Health of Russia; Infectiologist, Clinical Center for AIDS Prevention and Control, Ministry of Health of the Krasnodar Territory; Krasnodar, Russia; anfisas@mail.ru, 204
Galina K. Rafeyenko, Graduate Student, Department of Infectious Diseases and Epidemiology, Kuban State Medical University, Ministry of Health of Russia; Deputy Chief Physician for Laboratory Activities, Center for Hygiene and Epidemiology in the Krasnodar Territory, Krasnodar, Russia; gorses@mail.kuban.ru
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